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Anthony J Leonardi, PhD, MildS Profile picture
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9 Dec, 9 tweets, 2 min read
Pick your belief.

Cov2 will evolve...
Demonstrate your knowledge

SARS 1 evolves in vivo to be
SARS 2 evolves in vivo to be (when adapting to a mammalian species, mus musculus) pubmed.ncbi.nlm.nih.gov/32732280/
SARS 2 evolves in vitro to... doi.org/10.1101/2021.0…
SARS2 Spike evolution in vitro...
When reinfecting an individual with a more virulent Variant...
After 15 Generations of passaging, SARS1...

pubmed.ncbi.nlm.nih.gov/17222058/
For making it to the end.
We will grade this in 8 hours

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Anthony J Leonardi, PhD, MildS Profile picture
9 Dec
OK time to grade the poll-

The first question is your opinion. That's fair. The evidence is that it is getting more severe, so far. We'll talk about that more in a minute.
Nice one here. You guys are right, it gets worse for the animals with evolution. It adapts to us faster than we can adapt to it, if you get what I'm saying.
Yea, it gets worse for the mice. You know an animal it probably doesn't get worse in? Bats. They have interferon signaling to deal with this kind of nasty virus

Damn you guys are smart
Read 9 tweets
Anthony J Leonardi, PhD, MildS Profile picture
8 Dec
Ok. So perhaps the extreme affinity RBD is surmountable. AKA it is being neutralized. This is good news. Image
I mean, it's very good news. The alternative would have been really bad.
Damn it guys.
Read 4 tweets
Anthony J Leonardi, PhD, MildS Profile picture
3 Dec
The opposite of attenuation, it seems to me

The people who promised attenuation in fanciful papers in high-impact journals, laid out a path for democide and folly
And the co-dependent thinkers who could and did not criticize the work or comprehend the flaws show how our collective intellect lacks.

And those that took the work as reassurance are deserving of pity.
Read 5 tweets
Anthony J Leonardi, PhD, MildS Profile picture
27 Nov
This is my opinion on classrooms given the coming Omicron surge for which there are new vaccines in the pipeline
A pdf file for you drive.google.com/file/d/1NUywTm…
Kids need N95 as well. Updated.
Read 5 tweets
Anthony J Leonardi, PhD, MildS Profile picture
27 Nov
Hey guys. A lot of T cell hopium being irresponsibly passed around

I'm not cosigning that. If a mild case of Covid is giving lung diffusion issues, and given there is no published t cell correlate of protection, I think it's irresponsible and also disingenuous to write
Imagine I came to your field and said, "oh yea B cells will ramp up and protect you" if you were a researcher showing B cells were producing autoantibodies and producing severe cases.

You'd say, "wait a gosh darn minute, In some people that works to the opposite"
T cells are not some incantation you can invoke which will separate you from severe disease. Very sick people have the t cells

There's also no published correlate
there is no t cell marker to show who is a 30 year old that will get severe vs. mild illness based on their t cells
Read 6 tweets
Anthony J Leonardi, PhD, MildS Profile picture
26 Nov
Wow this guy is libelous

Yes, I completed a PhD program

Did my research and wrote my dissertation with the @theNCI at the National Institute of Health who PAID for it

Dissertation eprints.kingston.ac.uk/id/eprint/4198…

cofirsts in JCI pubmed.ncbi.nlm.nih.gov/26657860/
pubmed.ncbi.nlm.nih.gov/29212954/
I was 23 years old when I hypothesized T cells differentiated through FAS in a paracrine manner, and that it was carried through AKT

I have yet to publish the ramifications of the feed-forward mechanism in total
The NIH doesn't award degrees so must partner with other institutions to do so. (I wasn't accepted into oxcam's NIH partnership, lol)
Read 6 tweets

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