If you’re wondering what difference a booster makes, THIS is the key!
An mRNA booster on top of prior infection OR on top of two doses of vaccine confers 30X to 200X HIGHER neutralization titers versus Omicron.
Let’s talk about that! 🧵
An mRNA booster on top of prior infection OR on top of two doses of vaccine confers 30X to 200X HIGHER neutralization titers versus Omicron.
Let’s talk about that! 🧵
NOTE: If you see PMS20, it is an antibody resistant spike designed for purpose of studies.
In regards to infection. Analysis of plasma from convalescent individuals (1M, 6M, and 12M after previous infection) shows substantial Omicron neutralization escape. Remember, again, we are only looking at nAbs.
In regards to previous vaccination. Analysis of plasma from individuals who were previously vaccinated with either 2 doses of mRNA OR one dose of Johnson & Johnson shows substantial Omicron neutralization escape. Remember, again, we are only looking at nAbs.
Conclusion? Protection versus INFECTION with two doses is LOWER (as it is also with immunity from a previous infection) so we will likely see more reinfections or “breakthrough” infections, BUT protection versus severe IS likely still present. nAbs are only ONE part of your
immune response! What this shows is Omicron CAN be managed with hybrid immunity (combination of vaccination and previous infection) OR BOOSTERS, so GET PROTECTED. You can find this study here: drive.google.com/file/d/1zjJWsy…
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