Thread by @GrimaldesJ

@Parsifaler Protective effects of Epo and derivatives against lung injuries. In normal alveolus: intact cellular component (AEC I, AEC II, fibroblast) and pulmonary capillary.

@Parsifaler In injured alveoli: Treatment with epo protect the lung from injury-induced cell and tissue damage by reducing apoptosis, oxidative stress,and pulmonary fibrosis.Prevent pulmonary edema and inflammatory lesions and,therefore,maintain cell integrity @drakchaurasia @DrLBoominathan

@Parsifaler @drakchaurasia @DrLBoominathan EPO plays a key role in neuroprotection, cardioprotection, renoprotection or ventilation control. eurekaselect.com/61013/article europeanreview.org/article/18642 spandidos-publications.com/10.3892/ijmm.2… physoc.onlinelibrary.wiley.com/doi/10.1113/jp…

@Parsifaler @drakchaurasia @DrLBoominathan The protective effects of EPO towards lung tissue were attributed to its effects in inhibiting expression of nuclear factor-κB (NF-κB) in lung tissues, inhibition of interleukin-6 (IL-6) and tumour necrosis factor alpha as proinflammatory cytokines,

@Parsifaler @drakchaurasia @DrLBoominathan and improvement of anti-inflammatory cytokine IL-10 levels. A similar study was also conducted to assess rhEPO effect on human respiratory epithelial cell apoptosis and detected cytoprotective through induction of an antiapoptotic Bcl-xL/Bax phenotype.
onlinelibrary.wiley.com/doi/10.1002/jm…

@Parsifaler @drakchaurasia @DrLBoominathan EPO👉 POTS, Pulmonary Hypertension, Acute lung injury, Sepsis, Hypothalamic-Pituitary Axis, Neuroinflammation
researchgate.net/publication/46…

ahajournals.org/doi/10.1161/ci…

frontiersin.org/articles/10.33…

ncbi.nlm.nih.gov/labs/pmc/artic…

pubmed.ncbi.nlm.nih.gov/28629513/

ncbi.nlm.nih.gov/labs/pmc/artic…

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