The Great South African Mystery.

At this point, the US should have 4 times more immunity than SouthAfrica: 3 times more people have already had COVID in the US; our vaccination rate is more than double theirs.

But our current death rate is running 4 times higher. Why?
1/
I really don't know
3 possible reasons:

a) Differences in demographics & co-morbidities (although with prior waves, their deaths have tracked ours)
b)Inaccurate case ascertainment: they may have had far more people with prior Covid than has been reported
c) Different variants
2/
Many have pointed to the low death rate now in South Africa with the Omicron wave as an indication that Omicron is milder.

But I think our problem in the US is different: we are facing delta plus omicron. Not just omicron.
3/
Our capacity to take on more new cases is low, regardless of whether omicron is mild or not.

So as cases rise we just have to be careful and take precautions because for whatever reason, we are on a different trajectory. So don't look at South Africa for comfort.
4/
What about other countries in Africa? That's a question for another day. A different mystery.

Most African countries look 180 different than either the US or South Africa.
5/

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More from @VincentRK

17 Dec
When all is said and done, COVID vaccines have taken the sting out of COVID.

This is seen in cases versus deaths in UK: Deaths lower this time around even though cases skyrocket. Vaccines work. ImageImage
Also seen in the US but not as striking as in the UK probably because a) heterogeneity: some states are doing like UK, some worse; b) we are not as well fully vaccinated (60% vs almost 70% UK); c) UK had a bigger death toll in January; d) they are ahead of us in the omicron wave. Image
This is even better illustrated in countries that are much more fully vaccinated than the US or UK. Note how deaths have stayed low with recent waves even as cases went up. ImageImage
Read 8 tweets
15 Dec
In the global race to vaccinate against COVID, the US is lagging behind most developed countries. ig.ft.com/coronavirus-va…
In fact, countries which have lower vaccination rates than us are mainly those with inadequate access to vaccines.

Overall we are at #93 of about ~225 countries in %fully vaccinated. Excluding small countries with less than 200,000 population, we are at still >#60 in the race.
This is not due to limited vaccinate availability but vaccine hesitancy.

Vaccine hesitancy is not due to a uniform cause. There are many reasons. But mostly it is due to misinformation about Covid and Covid vaccines spread on media and social media.
Read 5 tweets
14 Dec
We are back up to nearly 120,000 cases a day in the US.

A small % getting seriously ill out of a large number is a large number. #Omicron Image
Healthcare workers are tired and weary. Another big wave when we have the tools to prevent and to mitigate will be sad.

Get vaccinated if you haven't.
Get your booster if you haven't
Wear masks
Continue other precautions.
You can see what Omicron can do here.
Read 5 tweets
14 Dec
Clinical trials:

See one
Do one
Teach one

Without leading a trial it's hard for you to realize how hard it is to do one and you may end up throwing stones at investigators trying to do their best. #ASH21
See this thread on how many people control the design of a trial. Most of this thread applies also to investigator initiated non randomized trials also. #ASH21
When you have this brilliant idea on how a trial should have been designed, in many cases the PI is also brilliant enough to know the same but they often had to make the hard choice of putting their foot down and not have a trial at all or compromise.
#ASH21
Read 8 tweets
13 Dec
Besides my Top 5 picks in myeloma at #ASH21 listed below the 3 most important findings being presented in myeloma this year are:

1) A variety of bispecifics showing high single agent activity
2) CAR-T efficacy
3) PFS improvement with Dara-VRd in GRIFFIN

#ASH21VR
Bispecifics and CART single agent activity is more than double of the single agent activity seen with existing drugs. Slide from @TomBmt133 #ASH21
Cilta-cel efficacy presented by @TomBmt133 is also outstanding and well summarized in this tweet by @ninashah33 #ASH21
Read 5 tweets
13 Dec
The same insulin that was sold for $21 in 1996 sells for $275 in 2021.

We must provide relief to patients whose lives depend on insulin, and fix the broken system. @MayoProceedings mayoclinicproceedings.org/article/S0025-…
Only in a broken system can you increase prices like this. Every time your competitor increases price you do on the same day. Because you can. Because there is no completion. Because there is no law that prevents hikes like this on the exact same product.
The price hikes succeed because there is a vulnerable population that needs the drug to stay alive and so has to spend whatever it takes. It is government that needs to step in and protect them. @t1international #Insulin4all
Read 6 tweets

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