When all is said and done, COVID vaccines have taken the sting out of COVID.
This is seen in cases versus deaths in UK: Deaths lower this time around even though cases skyrocket. Vaccines work.
Also seen in the US but not as striking as in the UK probably because a) heterogeneity: some states are doing like UK, some worse; b) we are not as well fully vaccinated (60% vs almost 70% UK); c) UK had a bigger death toll in January; d) they are ahead of us in the omicron wave.
This is even better illustrated in countries that are much more fully vaccinated than the US or UK. Note how deaths have stayed low with recent waves even as cases went up.
Doesn't mean COVID is not a menace or that it can't cause problems.
Doesn't mean vaccines alone will solve the problem. We need masks and other precautions
Doesn't mean we know what the future (or the next variant) may bring.
Doesn't mean our vaccination rates are adequate.
All it means is that vaccines work, if we take them, and they greatly reduce severity of COVID. Without vaccines we would have lost a huge number of lives.
Also note, right now fully vaccinated means 3 doses (if 3 doses are available in your country and age group).
One of the biggest concerns now is omicron. Much more contagious than delta. And we cannot underestimate it. It can spell trouble because all those mutations make it evade immunity from prior infection or vaccine. And it may not be all that mild.
At this point, the US should have 4 times more immunity than SouthAfrica: 3 times more people have already had COVID in the US; our vaccination rate is more than double theirs.
But our current death rate is running 4 times higher. Why? 1/
I really don't know
3 possible reasons:
a) Differences in demographics & co-morbidities (although with prior waves, their deaths have tracked ours)
b)Inaccurate case ascertainment: they may have had far more people with prior Covid than has been reported
c) Different variants
2/
Many have pointed to the low death rate now in South Africa with the Omicron wave as an indication that Omicron is milder.
But I think our problem in the US is different: we are facing delta plus omicron. Not just omicron.
3/
In the global race to vaccinate against COVID, the US is lagging behind most developed countries. ig.ft.com/coronavirus-va…
In fact, countries which have lower vaccination rates than us are mainly those with inadequate access to vaccines.
Overall we are at #93 of about ~225 countries in %fully vaccinated. Excluding small countries with less than 200,000 population, we are at still >#60 in the race.
This is not due to limited vaccinate availability but vaccine hesitancy.
Vaccine hesitancy is not due to a uniform cause. There are many reasons. But mostly it is due to misinformation about Covid and Covid vaccines spread on media and social media.
Without leading a trial it's hard for you to realize how hard it is to do one and you may end up throwing stones at investigators trying to do their best. #ASH21
See this thread on how many people control the design of a trial. Most of this thread applies also to investigator initiated non randomized trials also. #ASH21
When you have this brilliant idea on how a trial should have been designed, in many cases the PI is also brilliant enough to know the same but they often had to make the hard choice of putting their foot down and not have a trial at all or compromise. #ASH21
Only in a broken system can you increase prices like this. Every time your competitor increases price you do on the same day. Because you can. Because there is no completion. Because there is no law that prevents hikes like this on the exact same product.
The price hikes succeed because there is a vulnerable population that needs the drug to stay alive and so has to spend whatever it takes. It is government that needs to step in and protect them. @t1international#Insulin4all