1/3 Most answers to questions on #rapamycin, including dosing, you may find in this paper, if you read it slowly to its end. Anti-aging doses have no side-effects by definition: highest doses that do not cause side effects and you are comfortable with. ncbi.nlm.nih.gov/pmc/articles/P…
2/3 Doses and schedules are individual and must be personalized under doctor supervision. They may range widely. In my case, I never had side effects at relatively high doses (20 mg/2 weeks) compared to typical 6 mg/week. Will shift to 24, probably. But do not do that on your own
3/3 Rapamycin may be combined with (under supervision):
Daily physical exercise
Low carb diets
Metformin
Vit B3 derivates, D3
And others discussed in the paper on 1/3 tweet
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1/5
In 2014, I published "Koschei the immortal and anti-aging drugs" presenting anti-aging combo/recipe. Dr Alan Green named it Koschei formula and implemented in the clinic (by now he develops his own formula) pubmed.ncbi.nlm.nih.gov/25476900/#&gid…
2/5
Since that time, I have significantly updated the formula. One of notable change is Low Carb instead of Low Fat diet. Importantly, now there are many Koschei formulas depending on a particular person. It is addressed to MDs not patients.
3/5 Before I publish them, I present here One personalized example, suited to me
In order of importance
on the next page:
2. By 2010, 12 predictions of mTOR theory of aging have been confirmed (including life extension in mice). “The only prediction remained in 2010 to be confirmed: rapamycin will become the cornerstone of anti-aging therapy in our life time”
1/3Some senolytics (drugs that kill senescent cells selectively) may work because they are not senolytics, instead inhibiting kinases, including mTOR, acting as gero-suppressants
2/3Pure senolytics, a form of chemotherapy, are not selective enough for senescent cells, killing non-senescent cells too. Second, in some cases, killing senescent cells can further impair organ function. Imagine killing senescent neurons, beta-cells, retinal cells.
3/3There are solutions to these problems but clinical applications should be chosen very well to make senolytics work as intended.
Otherwise clinical trials of senolytics will fail one after another
@nntaleb 1/3 Every day we play Russian Roulette. Our decisions are NOT based on the probability of death. Instead, we do what other people do and especially ! what we already done successfully.
2/3 COVID-19 death probability for young girls >> old men (perhaps 1000 fold). But I observed that more old men than young girls are not wearing masks in the park.
3/3 The probability of death from: smoking > car accidents > > shark attack. People avoided swimming last year at Cape Cod watching others; no one avoids driving; smoking depends on other people smoking. And NOT taking rapamycin in theory maybe even more dangerous than smoking
“Fast food” is food that is prepared quickly and is eaten quickly or taken out.
I do not see anything bad in fast food, except that it contains a lot of carbs. Without carbs (bread, fries etc) it would be called ketogenic diet (almost)
The focus should be shifted from whether food is "fast" or "slow" to carb content. Zero carb fast food seems fine to me. Fast meat without bread for example
I see more problems with "Panera" type of food that is considered "slow" food but intentionally (!) based of High-Carbs recommendations (and low fat).
1/3 #Aging is the main problem during #coronavirus epidemic. Coronavirus is not lethal before aging (< 18 yo) and mortality increases exponentially with age, like mortality from aging itself. We may say that people still die from aging which allows the virus to become lethal
2/3 If infected, a person has ~ 3 times more chances to die compared with usual age-related mortality during one year For example (numbers are approximate), a 60 yo woman already has 1% chances to die before 61 birthday and ~3 % from the virus.
3/3 At age 80, ~ 5% natural death before 81 birthday and ~ 15% if infected.
Would anti-aging medicine of the future be helpful to decrease overall lethality?