1/3
Most answers to questions on #rapamycin, including dosing, you may find in this paper, if you read it slowly to its end. Anti-aging doses have no side-effects by definition: highest doses that do not cause side effects and you are comfortable with.
ncbi.nlm.nih.gov/pmc/articles/P…
2/3
Doses and schedules are individual and must be personalized under doctor supervision. They may range widely. In my case, I never had side effects at relatively high doses (20 mg/2 weeks) compared to typical 6 mg/week. Will shift to 24, probably. But do not do that on your own
3/3
Rapamycin may be combined with (under supervision):
Daily physical exercise
Low carb diets
Metformin
Vit B3 derivates, D3
And others discussed in the paper on 1/3 tweet

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Mikhail Blagosklonny

Mikhail Blagosklonny Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Blagosklonny

24 Sep
1/5
In 2014, I published "Koschei the immortal and anti-aging drugs" presenting anti-aging combo/recipe. Dr Alan Green named it Koschei formula and implemented in the clinic (by now he develops his own formula)
pubmed.ncbi.nlm.nih.gov/25476900/#&gid…
2/5
Since that time, I have significantly updated the formula. One of notable change is Low Carb instead of Low Fat diet. Importantly, now there are many Koschei formulas depending on a particular person. It is addressed to MDs not patients.
3/5
Before I publish them, I present here One personalized example, suited to me
In order of importance
on the next page:
Read 5 tweets
24 Sep 20
Out of my 91 papers on rapamycin, I select five for a brief introduction and historic perspective

1.Most recent and comprehensive analysis why rapamycin can and should be used to treat aging and prevent diseases

ncbi.nlm.nih.gov/pmc/articles/P…
2. By 2010, 12 predictions of mTOR theory of aging have been confirmed (including life extension in mice). “The only prediction remained in 2010 to be confirmed: rapamycin will become the cornerstone of anti-aging therapy in our life time”

pubmed.ncbi.nlm.nih.gov/20436272/
3.In 2010, Intermittent (6 days per 4 weeks) administration of Rapamycin slows aging and extends maximal lifespan in mice

ajp.amjpathol.org/article/S0002-…
Read 5 tweets
1 Sep 20
1/3Some senolytics (drugs that kill senescent cells selectively) may work because they are not senolytics, instead inhibiting kinases, including mTOR, acting as gero-suppressants
2/3Pure senolytics, a form of chemotherapy, are not selective enough for senescent cells, killing non-senescent cells too. Second, in some cases, killing senescent cells can further impair organ function. Imagine killing senescent neurons, beta-cells, retinal cells.
3/3There are solutions to these problems but clinical applications should be chosen very well to make senolytics work as intended.
Otherwise clinical trials of senolytics will fail one after another
Read 4 tweets
25 Jun 20
@nntaleb
1/3 Every day we play Russian Roulette. Our decisions are NOT based on the probability of death. Instead, we do what other people do and especially ! what we already done successfully.
2/3 COVID-19 death probability for young girls >> old men (perhaps 1000 fold). But I observed that more old men than young girls are not wearing masks in the park.
3/3 The probability of death from: smoking > car accidents > > shark attack. People avoided swimming last year at Cape Cod watching others; no one avoids driving; smoking depends on other people smoking. And NOT taking rapamycin in theory maybe even more dangerous than smoking
Read 4 tweets
5 Jun 20
“Fast food” is food that is prepared quickly and is eaten quickly or taken out.
I do not see anything bad in fast food, except that it contains a lot of carbs. Without carbs (bread, fries etc) it would be called ketogenic diet (almost)
The focus should be shifted from whether food is "fast" or "slow" to carb content. Zero carb fast food seems fine to me. Fast meat without bread for example
I see more problems with "Panera" type of food that is considered "slow" food but intentionally (!) based of High-Carbs recommendations (and low fat).
Read 8 tweets
10 Mar 20
1/3 #Aging is the main problem during #coronavirus epidemic. Coronavirus is not lethal before aging (< 18 yo) and mortality increases exponentially with age, like mortality from aging itself. We may say that people still die from aging which allows the virus to become lethal
2/3 If infected, a person has ~ 3 times more chances to die compared with usual age-related mortality during one year For example (numbers are approximate), a 60 yo woman already has 1% chances to die before 61 birthday and ~3 % from the virus.
3/3 At age 80, ~ 5% natural death before 81 birthday and ~ 15% if infected.
Would anti-aging medicine of the future be helpful to decrease overall lethality?
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(