1/ A big part of understanding the relationship between COVID cases and mortality is understanding the age structure of the waves

I've been looking at NYC "Respiratory" syndrome for ED visits (I was a member of the group that pioneered its use for public health 20 years ago)
2/ During prior influenza seasons, NYC would have up to 1,000 extra emergency department visits a day, much of the increase driven by babies and children (low prior immunity). Their share of ED visits would increase from ~20% to 40%

COVID19 was a completely different story
3/ Every day the number of ED visits rose higher. I remember seeing the first break in the relentless increase, and barely daring to believe that we had reached a peak. It was March 28. There were an extra 3,000 ED visits that day.

But even worse, they were almost adults.
4/ Older people in March 2020 had no prior immunity to COVID19 and we paid the price. Hospitals were completely overwhelmed. And then the morgues.

The Alpha wave caused a much smaller increase (and again the proportion of adults went up)

But pretty soon vaccinations kicked in
5/ During the summer lull and the early fall Delta wave you could literally see the proportion of elderly among the Respiratory ED group shrinking as vaccines did their magic.

In September, with social distancing fatigue, RSV came roaring back among children, as Delta simmered
6/ Which brings us to December.

I think we have 3 separate things going on.

Influenza is now rising
Delta is continuing
Omicron is kicking in.

We are not seeing a shift in ED visits towards the elderly, and that gives me great hope that the vaccines are holding
7/ There has undoubtedly been a bump up in Respiratory ED visits in NYC (it would be shocking if there weren't, in the midst of the greatest number of new cases diagnosed ever)

But it's on the order of 500 extra visits a day.

Historically speaking, that's not yet unusual
8/ And from what I can tell so far, the vast majority of those respiratory (and ILI, and COVID-like) ED visits are not getting admitted

There were a total of 200 pneumonia and influenza admissions (103 COVID+) on 12/19, which is only 36 cases above seasonal baseline

👍 🙏 🤞
9/ If you want to learn the backstory on the development of these syndromic surveillance systems (for bioterrorism, no less), can read @chrissyfarr excellent piece and my commentary here

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More from @Farzad_MD

21 Dec
1/ The rate of Omicron infections in NYC is unprecedented.

I'd estimate 100,000 infections occurred ... yesterday. Maybe 300,000 over the past 10 days.

1% hospitalization rate would mean 3,000 admits to come over the next few days

I hope it's much less than that (86 so far).
2/ Complicating matters, after driving down influenza (and RSV) to undetectable levels last year, we let up on social distancing, masking, and they have come back

So at least part of the increase in ED visits and hospitalizations will be due to influenza/RSV (especially in kids)
3/ On the other hand, using COVID-specific hospitalizations may be overcounting "incidental" cases among those admitted (or dying) for other reasons, especially if very high attack rate for Omicron

(got to rerun excess mortality analysis, @WeinbergerDan)
jamanetwork.com/journals/jamai…
Read 6 tweets
18 Dec
1/ The wide range of predictions here is appropriate given how little we know about severity.

Many are pointing to the @imperialcollege @nfergus study as support for a belief that Omicron has similar severity than Delta.

I don't think it does.

Let's dig in
2/ the paper is here if you want to read it for yourself. imperial.ac.uk/media/imperial…

They looked at UK COVID cases with (n=208,947) and without (n=15,087) the dropout associated w Omicron, and perform regression analyses to see what factors could predict Omicron

Date, for one
3/ for example, to predict whether a case is Omicron, you could find a clue by whether they are a reinfection (breakthrough).

There were 4,100 reinfections, but 36% of them were in the dropout group, compared w only 7% of the total cases. (OR 6.55 after controlling for all else)
Read 9 tweets
17 Dec
1/ Omicron is ripping through America right now, to an extent we won't fully realize until later

At this point, I think most people can hope to delay infection, but not to avoid it.

I don't think herd immunity is a realistic goal anymore

Here's what I think it means for us
2/ Even as the Delta wave continues to kill over a thousand people a day, Omicron is already here, and there is no reason to believe that the explosive growth we have seen in other countries, and in local outbreak (like Cornell University) isn't happening across the US already.
3/ an Intrinsic infectiousness that is perhaps 2-3 times higher than Delta, with a short incubation time, and at least some measure of immune escape- means that we are unlikely to get Rt below 1 (and the outbreak quenched) before it rips through a large proportion of susceptibles
Read 17 tweets
23 Oct
1/ Let's do an exercise together:

We've often heard people say something like "this innovative new service/company is good for patients and saves money, but there's no business model for it/ current reimbursement doesn't support it"

Step 1: Let's generate examples:
2/ I'll start.

But this is a group exercise, I need your nominations. Please try to give suggestions with some evidence behind them

*Advanced Care Planning
*Hospital at home
*Diabetes prevention program
*"SDOH" care navigation

(Used to be, telehealth)
3/ great work, tweeple

Clearly no shortage of ideas (with varying level of evidence) for things that could save money and be good for patients

The view espoused by many (including yours truly) has been that these services will flourish under value-based care

But not that easy
Read 19 tweets
20 Oct
The @AledadeACO annual awards!

1) Service.

Team Award: The Pharmacy Team!!
2) Accountability.

Individual Award:
Stephanie Sydorko (Tech Lead, Engineering)

Team Award:
CA-ledade (which has rapidly become our largest MSSP market)
3) Inclusion

Individual Award
Supreme Ally Commander
Michael Jones

Team Award
Health Equity Team (led by @kishadavismd)
Read 6 tweets
6 Oct
1/ Private Equity Investment As A Divining Rod For Market Failure: Policy Responses To Harmful Physician Practice Acquisitions

This is an important, thoughtful piece.

HT @LorenAdler
2/ As the title implies, the best way to think about the problem is that Private Equity points the way towards every opportunity for outsized financial gains, especially where there is arbitrage, or market failures.

PE investors use the word "rents" in a positive way
3/ As @brianwpowers @WillShrank have pointed out, if you create outsized opportunities in new payment models, private capital can accelerated that too

Though IMO they undersell the degree to which PE-backed groups in MA tend to focus on...risk adjustment

Read 7 tweets

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