For more than a year we've been talking about Global Vaccine equity.
Now it'll also be Global Pill Equity.
Unless something is done to get production revved up, as discussed here theguardian.com/commentisfree/…
Last week @CDCgov reported Omicron was 2.9% (that has now been revised)
*Today it is 73%*
Dominant across the US (with heterogeneity)
This is a doubling growth rate of 2 days or less
Replicates what has been seen in South Africa, UK, Denmark
Last week's 2.9% of cases being Omicron has been revised upward to 12.6%
12.6% -->73% of new cases are now Omicron
That's what you call exponential growth, folks
First data on booster vaccine effectiveness vs Omicron (581 cases): drop in protection vs symptomatic infection by 2 doses (AZ ->0, Pfizer-> <40%) restored to ~75% with 3rd shot Pfizer assets.publishing.service.gov.uk/government/upl…@UKHSA
The 95% CI presented here with relatively small number of Omicron cases overlap vs Delta, but certainly suggest less protection after 3rd dose.
For Omicron, essentially no protective effect of 2 AZ doses, 3rd goes to 71% (42,86); 2 Pfizer doses to 34%, 3rd doses to 76% (56,83)
Much more new beyond 1st look at Omicron vaccine effectiveness, summarized in a terrific thread by @kallmemeg
The overwhelming evidence for 3rd shot boosters *before* Omicron, reinforced by new data for benefit vs Omicron 1. The randomized trial of 3 shots vs 2 shots + placebo, 95% efficacy for preventing symptomatic infections across all age 16+ groups (N=10,125) cdc.gov/vaccines/acip/…
3. Marked reduction of hospitalizations and deaths in over 728,321 people with 3 shots vs matched 728,321 people with 2 shots, across all age groups thelancet.com/action/showPdf…
Great credit to this team for quickly getting us Omicron lab neutralization data. The bright side is that there is incomplete immune escape from vaccination👍
For people who had Prior Covid plus vaccination, the preserved Omicron neutralization level (FRNT) likely reflects solid protection. Not seen with 2 doses of Pfizer vaccine, but would expect that a 3rd shot, with its marked effect on raising nAbs, would simulate that
Here are some relevant data for the small sample. The 6 vaccinated individuals range from 10-39 days post-vaxx.
Take home point is how powerful hybrid immunity (vaccine + prior Covid) vs all variants that we've seen now, including Omicron
Does Omicron lead to less severe illness than prior variants ? We don't yet but let's review what is the basis for the hope /1 nytimes.com/2021/12/06/wor…
In South Africa, among those hospitalized, less requirement for ICU for those admitted compared with Delta /2 ft.com/content/d315be…
And the same, much less ICU need among those testing positive /3