Paxlovid just cleared by FDA!
Will be available in days
Just not enough of it to go around and that needs to be fixed ASAP
This is big, folks 👋👍👍
For more than a year we've been talking about Global Vaccine equity.
Now it'll also be Global Pill Equity.
Unless something is done to get production revved up, as discussed here
theguardian.com/commentisfree/…
The @WhiteHouse warns on insufficient doses of Paxlovid but @POTUS says "using the Defense Production Act if warranted"
It was warranted several weeks ago, Mr. President.
ft.com/content/9077c4… by @kiranstacey @FT

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More from @EricTopol

22 Dec
Omicron resulting in less severe illness
The latest roundup of data from this preprint with South Africa data and from Denmark ft.com/content/19065f… by @mroliverbarnes @jburnmurdoch @rmilneNordic
1. Less hospital admission in South Africa
2. Also 3X less likely in Denmark, but with a skew towards younger people testing positive
Also of note is the higher vaccinated proportion with Omicron in Denmark than was the case with Delta and prior variants
Read 7 tweets
20 Dec
Last week @CDCgov reported Omicron was 2.9% (that has now been revised)
*Today it is 73%*
Dominant across the US (with heterogeneity)
This is a doubling growth rate of 2 days or less
Replicates what has been seen in South Africa, UK, Denmark
Last week's 2.9% of cases being Omicron has been revised upward to 12.6%
12.6% -->73% of new cases are now Omicron
That's what you call exponential growth, folks
Yes, you read it right, a whopping 73%
Read 5 tweets
10 Dec
First data on booster vaccine effectiveness vs Omicron (581 cases): drop in protection vs symptomatic infection by 2 doses (AZ ->0, Pfizer-> <40%) restored to ~75% with 3rd shot Pfizer
assets.publishing.service.gov.uk/government/upl… @UKHSA

khub.net/documents/1359…
The 95% CI presented here with relatively small number of Omicron cases overlap vs Delta, but certainly suggest less protection after 3rd dose.
For Omicron, essentially no protective effect of 2 AZ doses, 3rd goes to 71% (42,86); 2 Pfizer doses to 34%, 3rd doses to 76% (56,83)
Much more new beyond 1st look at Omicron vaccine effectiveness, summarized in a terrific thread by @kallmemeg
— ~7% cases Omicron reinfections (0.4% Delta)
— 3.2X adjusted odds of household transmission (vs Delta)
— big growth advantage👇
Read 4 tweets
9 Dec
The overwhelming evidence for 3rd shot boosters *before* Omicron, reinforced by new data for benefit vs Omicron
1. The randomized trial of 3 shots vs 2 shots + placebo, 95% efficacy for preventing symptomatic infections across all age 16+ groups (N=10,125)
cdc.gov/vaccines/acip/…
2. Reduction in death by 90% for age 50+, 3 shots vs 2, among >840,000 people
nejm.org/doi/full/10.10… @NEJM
3. Marked reduction of hospitalizations and deaths in over 728,321 people with 3 shots vs matched 728,321 people with 2 shots, across all age groups
thelancet.com/action/showPdf…
Read 5 tweets
7 Dec
Great credit to this team for quickly getting us Omicron lab neutralization data. The bright side is that there is incomplete immune escape from vaccination👍
For people who had Prior Covid plus vaccination, the preserved Omicron neutralization level (FRNT) likely reflects solid protection. Not seen with 2 doses of Pfizer vaccine, but would expect that a 3rd shot, with its marked effect on raising nAbs, would simulate that
Here are some relevant data for the small sample. The 6 vaccinated individuals range from 10-39 days post-vaxx.

Take home point is how powerful hybrid immunity (vaccine + prior Covid) vs all variants that we've seen now, including Omicron
Read 4 tweets
7 Dec
Does Omicron lead to less severe illness than prior variants ? We don't yet but let's review what is the basis for the hope /1
nytimes.com/2021/12/06/wor…
In South Africa, among those hospitalized, less requirement for ICU for those admitted compared with Delta /2
ft.com/content/d315be…
And the same, much less ICU need among those testing positive /3
Read 9 tweets

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