Great credit to this team for quickly getting us Omicron lab neutralization data. The bright side is that there is incomplete immune escape from vaccination👍
For people who had Prior Covid plus vaccination, the preserved Omicron neutralization level (FRNT) likely reflects solid protection. Not seen with 2 doses of Pfizer vaccine, but would expect that a 3rd shot, with its marked effect on raising nAbs, would simulate that
Here are some relevant data for the small sample. The 6 vaccinated individuals range from 10-39 days post-vaxx.

Take home point is how powerful hybrid immunity (vaccine + prior Covid) vs all variants that we've seen now, including Omicron
A 2nd neutralization report today using an Omicron pseudovirus (above was with live virus) and less extensive immune escape, as explained here

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More from @EricTopol

9 Dec
The overwhelming evidence for 3rd shot boosters *before* Omicron, reinforced by new data for benefit vs Omicron
1. The randomized trial of 3 shots vs 2 shots + placebo, 95% efficacy for preventing symptomatic infections across all age 16+ groups (N=10,125)
cdc.gov/vaccines/acip/… Image
2. Reduction in death by 90% for age 50+, 3 shots vs 2, among >840,000 people
nejm.org/doi/full/10.10… @NEJM Image
3. Marked reduction of hospitalizations and deaths in over 728,321 people with 3 shots vs matched 728,321 people with 2 shots, across all age groups
thelancet.com/action/showPdf… Image
Read 5 tweets
7 Dec
Does Omicron lead to less severe illness than prior variants ? We don't yet but let's review what is the basis for the hope /1
nytimes.com/2021/12/06/wor…
In South Africa, among those hospitalized, less requirement for ICU for those admitted compared with Delta /2
ft.com/content/d315be…
And the same, much less ICU need among those testing positive /3
Read 9 tweets
29 Nov
This is actually a BIG deal and fully warranted, evidence based. Great to see!
Thanks @CDCgov @CDCDirector Image
Revised: Image
People are asking why not 3rd shots for age <18, i.e. teens?
There is no application yet from a vaccine manufacturer to FDA for age <18, so it can't be recommended yet. That will change soon......
Read 4 tweets
28 Nov
The US markedly lags many countries with boosters, in part because of poor messaging, and lack of priority to get *all* adults with fully restored vaccine effectiveness.
Would help vs Omicron, too. Boosters induce a striking increase in level & breadth of neutralizing antibodies.
Today's @washingtonpost editorial
"The [waning] phenomenon should compel all adults to get a booster shot."
Our editorial on boosters, @mtosterholm @PostOpinions
"Each day in the United States, the number of people with waning immunity greatly exceeds those who are getting newly vaccinated"
washingtonpost.com/opinions/2021/…
Read 4 tweets
26 Nov
The @WHO has named B.1.1.529 Omicron, a Variant of Concern [O, not Nu)
Here's their full statement, summary of data
who.int/news/item/26-1…
This is only the 5th Variant of Concern since the pandemic began: Alpha, Beta, Gamma, Delta, and now Omicron.
That it was not named as a Variant of Interest is interesting and raises concern ;-)
There have been thousands of uninteresting #SARSCoV2 variants
Read 5 tweets
24 Nov
Our oped on the big mistake @CDCgov on boosters: All adults, not just age 50 plus, need them. Here's why
@washingtonpost @mtosterholm
washingtonpost.com/opinions/2021/… @PostOpinions
Now is not the time to withhold a vital and validated means of boosting our efforts to contain the virus
Each day in the United States, the number of people with waning immunity greatly exceeds those who are getting newly vaccinated. Accordingly, rather than building our wall of population immunity, the United States is suffering attrition.
Read 4 tweets

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