Really tired about hearing how seroconversion will end the pandemic of sars cov 2.

All it ended was the efficacy of the monoclonals.

Think about it
And if this isn't obvious to you then you shouldn't pontificate about immunology.

And if conserved epitopes of T-cells are your ace in the hole in this pursuit then you are too stupid to see t cells did nothing for mild and moderate illness as shown in the AZN south africa trial
And you idiots, it is still a pandemic if you are having mild and moderate covid 19 every 6 months
Here is a summary:

Infections make immune escape, not immunity

that concludes my ted talk.

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More from @fitterhappierAJ

25 Dec
OK I believe it. However, in the real world it is more infectious.

List the reasons why you guys think that is👇

Also tell me why it's hitting kids harder
I don't think catching Omicron will give an immunity advantage to a subsequent Delta rechallenge.

So be prepared for that possibility.

There's a recency bias in 'evidence of attenuation'

No, this is just the most recent one out of many VOC that have usually been more severe.
Also there are limitations according to models and cell types:
Read 4 tweets
9 Dec
OK time to grade the poll-

The first question is your opinion. That's fair. The evidence is that it is getting more severe, so far. We'll talk about that more in a minute.
Nice one here. You guys are right, it gets worse for the animals with evolution. It adapts to us faster than we can adapt to it, if you get what I'm saying.
Yea, it gets worse for the mice. You know an animal it probably doesn't get worse in? Bats. They have interferon signaling to deal with this kind of nasty virus

Damn you guys are smart
Read 9 tweets
9 Dec
Pick your belief.

Cov2 will evolve...
Demonstrate your knowledge

SARS 1 evolves in vivo to be
SARS 2 evolves in vivo to be (when adapting to a mammalian species, mus musculus) pubmed.ncbi.nlm.nih.gov/32732280/
Read 9 tweets
8 Dec
Ok. So perhaps the extreme affinity RBD is surmountable. AKA it is being neutralized. This is good news. Image
I mean, it's very good news. The alternative would have been really bad.
Read 4 tweets
3 Dec
The opposite of attenuation, it seems to me

The people who promised attenuation in fanciful papers in high-impact journals, laid out a path for democide and folly
And the co-dependent thinkers who could and did not criticize the work or comprehend the flaws show how our collective intellect lacks.

And those that took the work as reassurance are deserving of pity.
Read 5 tweets
27 Nov
This is my opinion on classrooms given the coming Omicron surge for which there are new vaccines in the pipeline
Kids need N95 as well. Updated.
Read 5 tweets

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