🔬 Very nice study showing that #Omicron isn’t as efficient in entering cells compared to Delta & ancestral lineages.
👩🏾🔬 Why I find this cool: unlike other recent datasets, they’ve used an actual viral isolate (not pseudovirus) in an appropriate cell line & an animal model.
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👩🏾🔬 Why I find this cool: unlike other recent datasets, they’ve used an actual viral isolate (not pseudovirus) in an appropriate cell line & an animal model.
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https://twitter.com/SystemsVirology/status/1474759694971727872
In science using the right models & methods matters, but not all models recapitulate human conditions & no single method can give us the whole picture.
Why does this matter: b/c we tend to over-interpret & over-extrapolate.
So here the only appropriate conclusion is that…
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Why does this matter: b/c we tend to over-interpret & over-extrapolate.
So here the only appropriate conclusion is that…
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Omicron is not as efficient in cell entry & maybe infecting lung cells.
Does it mean the overall disease is less severe: we don’t know, remember that multiple systems get affected by the disease, looking at lungs alone won’t tell us if for instance clotting is also reduced
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Does it mean the overall disease is less severe: we don’t know, remember that multiple systems get affected by the disease, looking at lungs alone won’t tell us if for instance clotting is also reduced
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And lastly, remember that viral transmission is determined by viral physiology + host physiology AND BEHAVIOUR!
Uncontrolled transmission of any variant, regardless of how efficient it is in cell entry or causing disease, is bad!
We should never opt for unfettered transmission!
Uncontrolled transmission of any variant, regardless of how efficient it is in cell entry or causing disease, is bad!
We should never opt for unfettered transmission!
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