1/7 Read this, read it again, and understand it.
To me it is mindblowing. It points to the fact that lipids are PROTECTIVE. Part of the innate immune response, and it makes the 'infective cause' of CVD far more plausible.
2/7 Lipoprotein particle levels and their constituents are extensively altered by acute inflammation and infection (Gabay and Kushner, 1999). In fact, hypocholesterolemia (low cholesterol) has been consistently correlated with WORSE outcomes in critically ill patients
3/7 (Windler et al., 1994; Gordon et al., 2001; Gui et al., 1996; Marik, 2006). The molecular mechanisms underlying this are poorly understood but measurements of various lipid parameters in patients with severe sepsis or septic shock indicate that apoB lipoprotein levels can
4/7 be very LOW (Kitchens et al., 2003; Vermont et al., 2005; van Leeuwen et al, 2003). Because our data indicate that HOMEOSTATIC levels of apoB-expressing Lipoproteins are REQUIRED to provide adequate defense against quorum sensing invasive S. aureus infections,
5/7 clinical scenarios that result in extremely low apoB-containing lipoproteins may INCREASE the risk of invasive S. aureus infection including MRSA infections. Which kind of proves my theory that the 'bad cholesterol' and Lp(a)/ApoB is NOT OUT to kill us but to defend us
6/7 Remind me again ? Why are you so intent on lowering ApoB, LDL, Lp(a) ??? 🙄 Lipoprotein particle levels and their constituents are extensively altered by acute infection, and of course high circulating levels of OXIDIZED LDL contribute to impaired Th1 immunity.
7/7 More recent publications have described the effects of oxidized lipids on atherosclerosis and associated risk factors (123–130). The prevalence of antibodies that recognize epitopes of Ox-LDL seem to correlate well with the disease process

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Marion Holman

Marion Holman Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @holmanm

30 Dec
1/4 So sad for these poor souls who still believe that ⬇️ Cholesterol = good health. “I started taking Repatha last July. I had been previously taking Lipitor. I had side effects especially muscle pain and joint pain. I had been stopped for about 5 months.
2/4 My current Cardiologist said I should try Repatha due to the low number of reported side effects. During second months injections (every two weeks) I felt mild muscle pain and weakness. I took Tylenol to help with the pain. It has become progressively more insidious.
3/4 Yesterday, 5 days from last injection I could not get out a chair, running nose, trouble walking, can't go up and down stairs, severe pain in ankles, knees, hips and back. loss of upper body strength, itching.
Read 4 tweets
30 Dec
1/9 Chronic inflammatory diseases, such as rheumatoid arthritis, lupus, psoriasis, and infections, such as periodontal disease p.gingivalis & HIV, are associated with an increased risk of CVD. Patients with these disorders also have an increase in coronary artery calcium
2/9 measured by CT & carotid intima media thickness measured by ultrasound. WHY ?? Because inflammation & infections induce a variety of alterations in lipid metabolism that may initially DAMPEN inflammation or fight infection, but if chronic could contribute to the increased
/3
3/9 risk of atherosclerosis. The changes in lipids and lipoproteins that occur during inflammation & infection are part of the innate immune response & therefore are likely to play an important role in PROTECTING the host.
/4
Read 10 tweets
29 Dec
1/4 Ethan Weiss on Statins: Not sure if to laugh or cry. "And the statin trial comes with an important condition: the drug must not make people feel bad. I tell patients that statins are probably the best studied class of medicines in history" 😂😂😂
2/4 "My read of the data suggests that they are safe (they will not cause adverse events) except small effects on blood sugar which are real but small. I tell people that we will focus then on tolerability"
3/4 My thoughts: What planet does he inhabit ? He hasn't read the data, or he hasn't understood it, he has absolutely no idea about the mechanism of action of Statin drugs, and no clear idea about what actually causes heart disease. This guy lives in cloud cuckoo land.
Read 4 tweets
24 Dec
1/4 Here is one from the heart. I just had a conversation with my Step sister. She has been on 40mg Lipitor for 18 years. During that time she has been diagnosed with Breast Cancer (hardly surprising). She has undergone a knee operation (Statin muscle damage),
2/4 a shoulder operation (rotator cuff, very common with Statin use), and more recently has been suffering from hand and food tremors. She has recently seen a Neurologist, and the diagnosis is Parkinson's disease. I have tried and tried to tell her how Statin Drugs can
3/ cause this. She just will NOT listen. I feel so bloody helpless, because I know for sure from my research on these fungal mycotoxins that they are causal in ALL her problems. She has now been given Levodopa to try and counteract the Parkinson's disease.
Read 5 tweets
23 Dec
1/7 Statins are fungal secondary metabolites which selectively inhibit (HMG-CoA) reductase, the first enzyme in cholesterol biosynthesis.
’Secondary metabolite” is the euphemism that agenda-driven scientists and drug companies use for toxic Statins.
2/7 There are many ways to lower cholesterol. There are a few poisonous food mold toxins that will do the trick if you’re willing to take the risk:

To name but two

Ochratoxin-A (lactone/UV-flourescent)
Citrinin (inverted lactone/UV-fluorescent
3/7 A friend suffering from MND/ALS after using 80mg Lipitor took the drug to an INDEPENDENT lab to get the drug tested.
Two tests on 80 mg of Atorvastatin (Lipitor) came back with Ochratoxin A and Citrinin with 39 ug/g
Read 7 tweets
19 Dec
1/4 Huge eye opener for me. Statins forum again (sorry)
"I saw the lipidologist yesterday. The first cardiologist who saw me had never seen cholesterol scores as high as mine. The cardiology fellow hadn't either. Cholesterol was something like 600 and total was around 3500.
2/4 My xanthelasma reappeared (milder than before), so these docs were able to actually look at me & see the cholesterol leaking out of my eyes. They are putting me on Zetia, since I refused statins. They told me to eat a lot less saturated fat,
3/4 and that I probably had such high numbers because of crappy genes. (Probably ?? Didn't they do a test?)
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(