1/9 Chronic inflammatory diseases, such as rheumatoid arthritis, lupus, psoriasis, and infections, such as periodontal disease p.gingivalis & HIV, are associated with an increased risk of CVD. Patients with these disorders also have an increase in coronary artery calcium
2/9 measured by CT & carotid intima media thickness measured by ultrasound. WHY ?? Because inflammation & infections induce a variety of alterations in lipid metabolism that may initially DAMPEN inflammation or fight infection, but if chronic could contribute to the increased
/3
/3
3/9 risk of atherosclerosis. The changes in lipids and lipoproteins that occur during inflammation & infection are part of the innate immune response & therefore are likely to play an important role in PROTECTING the host.
/4
/4
4/9 But we prefer to BLAME the lipids !! I could lower my LDL in an instant by introducing more carbs to my diet, or using a PCSK9, or a Statin. Why would I ? Lowering LDL leads to reduced immunity, as witnessed by the PCSK9 users, who now suffer from all the autoimmune
/5
/5
5/9 diseases associated with lowering their ‘BAD’ Cholesterol. Also these guys are suffering from increased infections, especially UTI. If we could only learn that lowering insulin, infection, and inflammation has to be the way forward.
/6
/6
6/9 What does Lp(a) do ?: It preferentially accumulates oxidised lipids & binds them in a form where they cannot be immediately excreted from the plasma. It also puts a great big sticky label on them that allows them to firmly bind to DAMAGED tissue.
Only Lp(a) does this.
/7
Only Lp(a) does this.
/7
7/9 All this effort regarding cholesterol is beyond belief. We keep parsing this tree of lipids deeper & deeper & it's always the next molecule that's going to be the causative agent. ( LDL, then Lp(a), then ApoB, then we look at it again and figure, nope, that's not it,
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8/9 look again, look harder !
Like fusion power, always 50 years away.
It's just an obvious red herring. I don't understand why so much energy is still going into the subject
/9
Like fusion power, always 50 years away.
It's just an obvious red herring. I don't understand why so much energy is still going into the subject
/9
9/9 (aside from that funded by drug companies.) 😉
CVD is all about damage and clotting. The focus on cholesterol is, as it always has been, bizarre.
I’m also not a firm believer that your liver manufactures Lp(a) to kill you. 😂
CVD is all about damage and clotting. The focus on cholesterol is, as it always has been, bizarre.
I’m also not a firm believer that your liver manufactures Lp(a) to kill you. 😂
8/
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