I had to break this down into the business side and the science as my notes are too big for one thread.
1/ $DNA has a multi tier share structure which is very different from most companies in the market. They concentrate the vast majority of the voting power to the insiders.
2/ The class A shares are the common stock and count for 1 vote. The class B shares are for insiders and rewards for insiders. They get 10 votes per share and convert to class A shares if they are sold or the person quits or is fired.
3/ They have reserve for class C which isn't being used, but has no voting power.
4/ In Q3 they add 10 new programs to bring their total to 61 active programs.
5/ They have a lawsuit open from shareholders claiming they omitted important information from some of their filings. I see these suits a lot in the market and most of them are a waste of time and go nowhere.
6/ They have just under 35 million warrants outstanding for a 1 for 1 stock exchange at a value of $11.50. They can be redeemed if the stock price is above $18.
7/ First lock up is 180 days and the major lock up will be 1 year for insiders.
8/ They have 7 ventures in which they have ownership stakes. They have multiple partners, but they typically have fees, royalties or milestones like Roche or Cronos. These are the companies they have equity stake in.
9/ Joyn Bio is a joint venture company formed between a subsidiary of $DNA and Bayer Ag. Its focused on engineering microbes for agricultural applications.
10/ Motif Foodworks is a company they licensed technology to for an equity stake that is focused on synthetic biology in the food industry.
11/ Allonnia is a company they licensed technology to for an equity stake that is focused on synthetic biology in the bio-remediation and bio-recovery industries.
12/ Arcaea is a company they licensed technology to for an equity stake that is focused on synthetic biology in the personal and beauty care products.
13/ Ayana Bio is a company in which they hold a majority stake that is focused on the design of bioactive compounds for health and wellness.
14/ Verb Biotics is a company in which they hold a majority stake that is focused on the design of probiotics and nutrition.
15/ Many of these companies are very small and speculative. They could easily fail and these investments and programs could go with them.
16/ Downstream Value comes in the forms of Royalties, Equity Stakes and/or Milestones. They tailor their deals based on the size of the companies they are working with.
17/ This typically results with them getting revenues, milestones and royalties from the bigger companies and royalties and equity from the smaller companies.
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I had to break this down into the business side and the science as my notes are too big for one thread.
1/ Their mission is cell programming. They are not a fully vertical platform from source to customer. They are built to program cells for other companies that sell to the customers.
2/ That means they also have suppliers. Key public suppliers to them are $TWST for DNA and $BLI for workflow machines. They then sell the cells they design to their customers.
Synthetic Biology and My Cell has an app for that:
Some day we might go from my "cell phone" has an app for that to my "cell" has and app for that. This might sound like science fiction, but it might not be as hard as you think.
1/ I spent many years studying the cellular communications pathways inside our cells. These are the pathways that take signals from the receptors which receive signals from the outside and transmit them to the nucleus.
2/ The signal is transmitted to the nucleus and turns on genes. Those changes result in an output of some kind in the form of cell behavior. It wasn't until I started to study Synthetic Biology did it makes sense.
1/ The pluripotent stem cell is capable of developing into many types of cells. We use to believe that cells could only develop in one direction, but a scientist named Shinya Yamanaka discovery how to take a mitotic cell and revert it back into a stem cell.
2/ This process was celled induced Pluripotent Stem cells. The ability to turn any cell back into a stem cell just by treating it with a combination of various transcription factors.
A look at the editing that goes into CAR-T and CAR-NK cell therapies.
1/ The first major challenge to any cell therapy is to overcome the rejection of the cells by host immunity. All cells have a MHC code on them that labels them as "self".
2/ When a person's MHC code does not match someone else, you can get the cells attacking the patient or the patients immune cells attacking the donor cells.
For Whom does the Cell Toll? (A History of cell therapies)
A look at the history of cell therapies and editing.
1/ Engineering cells for cell therapies brings together the best of synthetic biology and genomics. Its about taking cells and reprogramming them into a therapy to treat disease.
2/ My focus in this space has been highly geared toward immune cells like T and NK cells. I will look at the evolution of cell therapies and where we are going.