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Eric Topol Profile picture
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6 Jan, 4 tweets, 2 min read
The US vaccine booster rate is dreadfully low
@OurWorldinData
You will see that play out by many vaccinated, waned, hospitalized patients
(already happening, but it's a country without data)
Vaccine effectiveness vs hospitalization with Omicron infection
2-shot 52%
3-shot 88%
That the US has not made "fully vaccinated"= 3 shots ignores these data and will lead to a large number of preventable hospitalizations
erictopol.substack.com/p/humans-2-omi…
Illustrating this important issue, the current rise of hospitalizations in a large health system among vaccinated, waned vs vaccinated, boosted
For comparison, the US is at 22% 3-doses (and that includes J&J 2-doses)
ft.com/content/19cc8f…

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More from @EricTopol

Eric Topol Profile picture
6 Jan
I keep looking at New York State as the indicator for what's to come in the US. For new cases/capita, it's leading the US. If it were a country, it would now be the 2nd highest in the world after Ireland. In contrast to the CDC, the state has a lot of solid new data to review /1
Hospitalizations are rising, sharply
The level of patients requiring ICU beds is nearly as high as the monster 3rd wave (well below the 1st wave) /2
newsnodes.com/us_state/NY
coronavirus.health.ny.gov/daily-hospital…
NYS "fully vaxx" rate is 72% and also has better than US avg for older age groups.
There's some reduction of vaccine effectiveness vs hospitalization recently, but the overwhelming proportion of patients admitted are among the unvaccinated /3
Read 5 tweets
Eric Topol Profile picture
22 Dec 21
Paxlovid just cleared by FDA!
Will be available in days
Just not enough of it to go around and that needs to be fixed ASAP
This is big, folks 👋👍👍
For more than a year we've been talking about Global Vaccine equity.
Now it'll also be Global Pill Equity.
Unless something is done to get production revved up, as discussed here
theguardian.com/commentisfree/…
Read 4 tweets
Eric Topol Profile picture
22 Dec 21
Omicron resulting in less severe illness
The latest roundup of data from this preprint with South Africa data and from Denmark ft.com/content/19065f… by @mroliverbarnes @jburnmurdoch @rmilneNordic
1. Less hospital admission in South Africa
2. Also 3X less likely in Denmark, but with a skew towards younger people testing positive
Also of note is the higher vaccinated proportion with Omicron in Denmark than was the case with Delta and prior variants
Read 7 tweets
Eric Topol Profile picture
20 Dec 21
Last week @CDCgov reported Omicron was 2.9% (that has now been revised)
*Today it is 73%*
Dominant across the US (with heterogeneity)
This is a doubling growth rate of 2 days or less
Replicates what has been seen in South Africa, UK, Denmark
Last week's 2.9% of cases being Omicron has been revised upward to 12.6%
12.6% -->73% of new cases are now Omicron
That's what you call exponential growth, folks
Yes, you read it right, a whopping 73%
Read 5 tweets
Eric Topol Profile picture
10 Dec 21
First data on booster vaccine effectiveness vs Omicron (581 cases): drop in protection vs symptomatic infection by 2 doses (AZ ->0, Pfizer-> <40%) restored to ~75% with 3rd shot Pfizer
assets.publishing.service.gov.uk/government/upl… @UKHSA

khub.net/documents/1359…
The 95% CI presented here with relatively small number of Omicron cases overlap vs Delta, but certainly suggest less protection after 3rd dose.
For Omicron, essentially no protective effect of 2 AZ doses, 3rd goes to 71% (42,86); 2 Pfizer doses to 34%, 3rd doses to 76% (56,83)
Much more new beyond 1st look at Omicron vaccine effectiveness, summarized in a terrific thread by @kallmemeg
— ~7% cases Omicron reinfections (0.4% Delta)
— 3.2X adjusted odds of household transmission (vs Delta)
— big growth advantage👇
Read 4 tweets
Eric Topol Profile picture
9 Dec 21
The overwhelming evidence for 3rd shot boosters *before* Omicron, reinforced by new data for benefit vs Omicron
1. The randomized trial of 3 shots vs 2 shots + placebo, 95% efficacy for preventing symptomatic infections across all age 16+ groups (N=10,125)
cdc.gov/vaccines/acip/…
2. Reduction in death by 90% for age 50+, 3 shots vs 2, among >840,000 people
nejm.org/doi/full/10.10… @NEJM
3. Marked reduction of hospitalizations and deaths in over 728,321 people with 3 shots vs matched 728,321 people with 2 shots, across all age groups
thelancet.com/action/showPdf…
Read 5 tweets

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