Given below observation, an obvious question to ask is 'did any models consider a scenario that could give insight into what a Tier 4-like change in behaviour could look like?' 1/
If we look at scenarios that assume a prolonged return to behaviour levels seen in earlier steps of the reopening in England (e.g. Step 0, S1, S2 etc. below from 11 Dec: cmmid.github.io/topics/covid19…), models predict far lower levels of hospitalisations and deaths. 2/
Could summarise above scenarios as: 'If you want epidemic curve to look like that, this is the sort of virus characteristics and behaviour change that would be required - whether behaviour change comes from a policy, or pin hopes on spontaneous individual-level change' 3/
Remember, the virus doesn’t care whether a reduction in social contacts comes from individual-level spontaneous behaviour change or a top-down policy. So if we want to understand what's driving epidemic dynamics, makes sense to compare like-with-like as much as possible. 4/
Comparing scenarios without much behaviour change with a reality in which there was huge (and disruptive) change in social interactions creates a risk of attributing a wrong (or incomplete) explanation to the patterns we've seen... 5/
E.g. It might be tempting to attribute all difference between a baseline scenario and reality to presumed overestimation of severity (see below for some nuances on this point) rather than the lack of spontaneous behaviour change in baseline scenarios: 6/

The distinction is important – if explanation is severity alone, implies much of the susceptibility to Omicron was never there in first place; but if behaviour played a role too, more susceptibility still remains out there... 7/
There was an analogous need to understand drivers of dynamics in summer 2020. If 1st wave had declined because of immunity (which some claimed at the time, despite available data suggesting otherwise), a terrible 2nd wave wasn't possible.... 8/
But if 1st wave decline was mostly behaviour change (which evidence suggested), it meant there was still considerable susceptibility out there, and risk of bad 2nd wave. It's not enough to just look at an epidemic curve; we need to understand *why* it has the shape it does... 9/
Over past century, epidemiology has moved from description ('I think this year's epidemic will look like last year') to explanation ('what causes epidemics to rise & decline? Why would this year be any different?) If we want to understand future of COVID, we need to do same. 10/
As you may have noticed, mobility patterns weren't exactly same as last winter – especially retail & recreation. And now seeing post-Christmas increase. Which makes it all more important to understand what shaped epidemic over past month or so, and what might happen next. 11/11

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More from @AdamJKucharski

10 Jan
Some thoughts on the evolutionary trajectory of SARS-CoV-2 so far, how it compares to other viruses, and what might happen next... 1/
For seasonal coronaviruses & flu, we see a pattern of 'antigenic turnover' over time - circulating viruses give rise to new variants that escape prior immunity against infection, immunity builds against these new variants, then these in turn spawn new variants... 2/
When infections evolve to escape immunity like this, we typically end up with an evolutionary tree that looks like a lopsided ladder as new variants sequentially replace their 'parent' variant lineages (below from: journals.plos.org/ploscompbiol/a…) 3/
Read 12 tweets
6 Jan
Flu is often quoted as an example of 'living alongside' an infection (even though countries work hard to reduce disease burden via vaccination). But I think sexually transmitted infections are also an important example to consider... 1/
For STIs, preaching abstinence to prevent infection has gradually fallen out of favour (e.g. thelancet.com/journals/langl…). Instead, societies deal with ongoing circulation of these infections using other tools... 2/
Testing & informing partners gives people information on their infection status (and treatment can reduce duration of infectiousness). Contacts can be made less risky with protection (e.g. condoms). And susceptibility can be reduced through vaccination (or, for HIV, PrEP)... 3/
Read 4 tweets
22 Dec 21
Unfortunately, this oft-quoted Spectator tracker of COVID 'scenarios vs outcomes' seems at best muddled and at worst actively misleading. A thread on some weird comparisons - and how to do better critiques...
data.spectator.co.uk/category/sage-… 1/
First plot is comparison of scenarios for increased R values with later data. Crucially, these weren't predictions about what R would be (R estimate that week was 0.9-1.1, so pretty flat epidemic). Rather, report showed what could happen if R increased beyond current range... 2/
Not sure why they cut out the R=2 scenario from original plot (which would've made it obvious these were illustrative - assets.publishing.service.gov.uk/government/upl…). TBF SPI-M plot could have included horizontal line to illustrate what R=1 looks like, but don't need a model to draw a flat line... 3/
Read 21 tweets
21 Dec 21
Any writer who claims 'UK models always overestimate COVID numbers' is either lazy or trying to mislead their readers. A few illustrations... 1/
A surprisingly under-reported example is early UK scenario models (although @anthonybmasters & @d_spiegel correctly flag it in 'Covid by Numbers'). Some point estimates from initial 'recurrent lockdown' scenarios were lower than what actually occurred:
2/
Then there’s the July 2020 report from @acmedsci, which used Imperial modelling. It was designed to be a plausible worst case scenario, not a forecast, but ended up strikingly close to reality (with Alpha increasing risk & vaccines decreasing it): 3/

Read 7 tweets
27 Nov 21
A lot of Twitter currently seems to be a split of either fatalism about Omicron variant, or advocacy for retweetable-but-flimsy measures that are unlikely to suppress transmission of a genuine threat. Discourse needs to be much better - for this situation and future pandemics. 1/
This piece is one of the few I’ve seen IMO asking the right sorts of questions. If we need to update vaccines (still a big if), how much time do we need to buy? What will the scientific, logistic and regulatory challenges be?
thetimes.co.uk/article/how-lo…
2/
And, of course, if we need to update vaccines, how do we get them to places most affected in equitable way? 3/

Read 4 tweets
26 Nov 21
Reminder that reactive travel bans typically slow but don’t stop importations. If new B.1.1.529 variant genuinely more transmissible/can evade immunity to some extent, reasonable to assume already undetected cases in other regions... 1/
For example, Israel had multi-pronged efforts to keep Delta out (which bought time for more vaccination), but even so the rise was only a couple of months behind UK: 2/
Countries should therefore have plan to deal with local outbreak. Recent reintroduction of control measures across Europe may be helpful coincidence (in short term at least), reducing contacts & making it harder for imported cases to establish... 3/
Read 7 tweets

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