interesting paper (with excellent editorial from Jianzhi Zhang nature.com/articles/d4158…) that proposes an "adaptive mutation bias" reducing mutation rates in functionally constrained regions of the genome
so what would Delbrück and Luria think? genestogenomes.org/luria-delbruck… 1/3
so what would Delbrück and Luria think? genestogenomes.org/luria-delbruck… 1/3
https://twitter.com/Grey_Monroe/status/1481298489191837701
as Jianzhi Zhang points out, there are two logical possibilities here:
1) natural selection might lead to the evolution of machinery that reduces mutations in essential genes/regions, where a mutation is highly likely to be deleterious 2/4
1) natural selection might lead to the evolution of machinery that reduces mutations in essential genes/regions, where a mutation is highly likely to be deleterious 2/4
or
2) reduced mutagenesis might be intrinsic to features associated with essential coding regions, or just a by-product of other biological processes 3/4
2) reduced mutagenesis might be intrinsic to features associated with essential coding regions, or just a by-product of other biological processes 3/4
whether 1) is true, and selection might indeed lead to machinery that *promotes* beneficial mutations & makes deleterious ones less likely,
is up for debate,
but I commend @Grey_Monroe & @PlantEvolution for their laborious ++ mutation accumulation experiments and elegant paper
is up for debate,
but I commend @Grey_Monroe & @PlantEvolution for their laborious ++ mutation accumulation experiments and elegant paper
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