interesting paper (with excellent editorial from Jianzhi Zhang…) that proposes an "adaptive mutation bias" reducing mutation rates in functionally constrained regions of the genome

so what would Delbrück and Luria think?… 1/3
as Jianzhi Zhang points out, there are two logical possibilities here:
1) natural selection might lead to the evolution of machinery that reduces mutations in essential genes/regions, where a mutation is highly likely to be deleterious 2/4
2) reduced mutagenesis might be intrinsic to features associated with essential coding regions, or just a by-product of other biological processes 3/4
whether 1) is true, and selection might indeed lead to machinery that *promotes* beneficial mutations & makes deleterious ones less likely,
is up for debate,
but I commend @Grey_Monroe & @PlantEvolution for their laborious ++ mutation accumulation experiments and elegant paper

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Thomas Christie Williams

Thomas Christie Williams Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Williams_T_C

16 Dec 21
my article on childhood viral respiratory diseases is now out @RoyalSocBio… (delighted to be sandwiched in between a piece on oxylipins and another on latent lepidopterans)🧵 Image
I highlight the increasing burden of childhood viral respiratory disease on hospital services…
how this demand evaporated during the first lockdown, and what this has taught us about how these viruses spread… Image
Read 7 tweets
21 Sep 21
the #BronchSTART study dashboard… already contains a huge amount of data
and you can see that there have been unusual regional variations in the RSV season this year 🧵 1/n
normally the RSV season starts in the urban centres of the NW of England and London at around the same time… and spreads to the rest of the country in the following 3 weeks 2/n
this year, like in previous ones, RSV did start (early? late?) in the urban centres of the NW of England and peaked at epidemiological week 30 3/n
Read 10 tweets
10 Sep 21
a few months ago, a group of us, reading reports of unusual patterns of RSV circulation in Australia (a "winter in summer"…)
wondered whether the same might happen this year in the United Kingdom and Ireland 🧵1/n
the premise was simple: could we use a simple online questionnaire, collecting only non-patient identifiable information,

to better understand the geographical dynamics and clinical manifestations of RSV circulation in 2021/22?

It turns out we can 2/n
thanks to BronchSTART, a study powered by hundreds of clinicians in Emergency Departments, working as part of the PERUKI Network, we can now watch this year's RSV epidemic play out in real time 3/n
Read 16 tweets
1 Sep 21
a lot of interest in my thread describing the impact of RSV this year on infants and children in the UK
and questions about whether children are more at risk from RSV or COVID-19 (new🧵) 1/n
RSV (respiratory syncytial virus) is an RNA virus that causes upper and lower respiratory tract infections in children
our recently published review in Vaccine gives an in-depth introduction to the epidemiology and virology 2/n
In the average year many thousands of children across the UK develop RSV infection: in 2016 there were 36,028 admissions for children <5 in England… @PHardelid with around ~700 intensive care admissions 3/n
Read 14 tweets
31 Aug 21
just finished nights on call, and found that a toxic triad of RSV, rhinovirus and SARS-CoV-2 is starting to stretch the Scottish hospital I work in to its limits
it's only August
what went wrong? 🧵1/n
Problem 1. We failed to contain SARS-CoV-2. 2/n
This is a Problem for 3 reasons.
Firstly, there are the (very) small number of children with serious SARS-CoV-2 infection. 3/n
Read 31 tweets
22 Apr 21
as lockdown is lifted across the UK and Ireland, what could happen in paediatric emergency departments and hospitals this summer? a 🧵1/n
firstly, some context

in the first year of the pandemic, there were 5,336 hospital admissions associated with a positive SARS-CoV-2 test in children in England 2/n
but ...

in a typical year in England, there are ~36,000 admissions for bronchiolitis (mainly caused by Respiratory Syncytial Virus, RSV) in infants under the age of 1… 3/n
Read 14 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!


0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy


3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!