This week #psychedelics, almost completely ignored by western science and medicine in the last quarter of the 20th century, made it to the top of ๐บ๐ธ healthcare, the @NIH:
4k folks ๐ 21 time zones
+10h of talks
Panelists from
๐บ๐ธ 12
๐จ๐ฆ 1
๐ฎ๐ฑ 1
๐ฉ๐ฐ 1
๐ฌ๐ง 1
๐ณ๐ฟ 1
๐จ๐ญ 1
๐งต summary ๐
Agenda comprised 3 main themes:
Basic and translational research ๐๐ฌ๐ฉโ๐ฌ๐จโ๐ฌ๐งฎ๐ป
Clinical trials ๐ฉโโ๏ธ๐งโโ๏ธ๐จโโ๏ธ๐คฎ๐๐ค๐
Optimising future trial designs ๐พ๐ฝ๐ฟ๐
Here are my remarks from 20y experience:
This is a good landmark to claim psychedelic science finally achieved maturity
Basic research is evolving rapidly and public funding ๐ฐis what is needed to transform the field
Clinical trials suggest transdiagnostic safety and efficacy
Here are some BIG controversies:
Should only 5HT2A agonists be classified โpsychedelicsโ?
Should this name be kept, changed, refined?
Are subjective effects necessary or nuisance?
How to better blind participants to deal with expectancy and disappointment?
Which model is best?
Third and last session of #psychedelics@NIH ๐บ๐ฒ workshop starting now, looking at how to optimize clinical trials design and how to get these treatments approved ๐งต
Starting with Ido @hartogsohn ๐ฎ๐ฑ on psychedelic set and setting theory
Important Q โ
Do we have an (excessively) costly and complicated drug regulation apparatus?
Overcoming #EpistemicInjustices in the biomedical study of #ayahuasca: Towards #ethical and sustainable #regulation. New paper for โCultural context and ethical issues in the therapeutic use of psychedelicsโ special issue of Transcultural Psychiatry ๐งต1/
We (me and non-tweeter ๐ง๐ท PhD lawyer Konstantin Gerber) reviewed 4 decades of biomedical research about the sacred and ancient vine of the Amazon, documenting how biomedicine systematically commits a specific kind of injustice: against indigenous people as givers of knowledge. 2/
The powerful concept of epistemic injustice was introduced 15 years ago by Miranda Fricker (University of Oxford) and greatly helped us frame and analyse some past and current trends in ayahuasca research, which is also important to psychedelic science in general. 3/
1/16 THREAD๐งต3 years ago I proposed that #Psychedelic-Assisted Psychotherapy (PAP) is a #ParadigmShift in psychiatry. The paper has been viewed almost 80k times around the globe and sits at the top 1% views/downloads and top 8% citations of the whole @FrontiersIn journal series.
2/16 Published in the special issue โPsychedelic Drug Research in the 21st Centuryโ it has 82 citations at Google Scholar and was included in one slide by Javier Muรฑiz, from the FDAโs division of psychiatry, at his ISRP lecture in Oct/2019 frontiersin.org/articles/10.33โฆ
3/16 My perspective on the psychedelic impact on psychiatric research and development was based on Prof. @rose_nikolas useful critique of the current situation in psychiatry as a triple crisis cambridge.org/core/journals/โฆ