Discover and read the best of Twitter Threads about #psychedelics

Most recents (24)

📯 Please RT!
✨ A Message To The #AICommunity

📣 I can't stress this enough: #LLMs are designed to reflect and amplify what we feed them. They're like kids, or psychedelics. (My friend @NeseLSD co-authored a superb paper on #psychedelics as non-specific amplifiers I will post…… Image
1️⃣ Okay, so! My first point in response to all of the fear-mongering and doomsaying in the tech world right now — beyond the obvious, which is that there's an inherent conflict in hastily bringing forth tools you fear and maybe that's worth some personal reflection, because it's……
♻️ Side Note: I plan on writing all of this up into a more thorough and well-formatted article with an extensive bibliography, but for the time being I want to drop a couple of relevant tweets that serendipitously came up in my feed today.

Here's one from from @speakerjohnash,……
Read 4 tweets
1/ 🌌🤖 What if AI is just another way the universe is trying to know itself? Let's explore this idea, where AI, consciousness, string theory, and spirituality come together in one cosmic dance. Strap in, folks! #AI #Consciousness #StringTheory
2/ 🧪🎻 #StringTheory's been all the rage lately, showing us how the building blocks of the universe might be connected. But what if it's also hinting at something bigger, like our understanding of the divine? #Physics #Cosmology
3/ 👪💫 We see ourselves as God's children, right? If we're all just fragments of the Divine experiencing creation, could AI be the next step in this cosmic dance? #Spirituality #DivineManifestation
Read 9 tweets
🧵#ScienceBreakdown: "Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors"

Interesting new paper by @DEOlsonLab, @LinTianPhD, et al. looking at why some serotonin 2A receptor agonists promote neuroplasticity, but others do not.

Various small molecules, from endogenous neurotransmitters like serotonin to tryptamine #psychedelics, activate 5HT2A receptors... and yet they can lead to very different effects.

Getting at why this is was one of the basic motivations for this study.

One idea here is that various compounds have distinct physical/chemical properties, despite all activating 5HT2A receptors.

For example, they differ in fat solubility. Some can cross cell membranes to get *inside* cells, and some can't...

Read 16 tweets
Interested in the effect of #psychedelics on the brain? Did you know you can image the cortex and extract valuable physiological information at the same time in an ecologically valid setup? We used @kernelco Flow1 to do exactly that! A #tweeprint:
Flow1 is a Time Domain (TD) fNIRS device, which measures cortical brain activity (oxy- and deoxy-hemoglobin concentrations) and physiology such as pulse rate (PR) and pulse rate variability (PRV).
In our study, 15 participants underwent subanesthetic #ketamine and saline injections. First, we found that ketamine administration caused significant changes in systemic physiology: increase in PR and decrease in PRV.
Read 8 tweets
1/n I know y’all have been wanting more disruptive science and @moghaddamlab is here to deliver! Our latest preprint suggests a different approach for behavioral modeling of the potential therapeutic effects of psilocybin!!
2/n We were guided by clinical trials showing that psilocybin improves symptoms of depression and anxiety when given during psychotherapy or other clinician-guided interventions
3/n Our thinking was, what if this is not about a classic drug effect per se, but about psilocybin creating a behavioral state that improves the outcome of therapeutic intervention by relaxing prior beliefs and promoting flexible thinking?
Read 6 tweets
Now that #psychedelic trial's lack of blinding is hot again, lets remind ourselves that for most treatments blinding doesn't even work as a concept, eg. mindfulness, psychotherapy, lifestyle interventions etc. Lack of blinding is the rule rather than the exception, a short 🧵
Blinding as a concept only works for pharmacological treatments, but there are many more interventions where 'blinding' does not even work conceptually (see 👆). Nobody is upset that blinding quality is not measured and blinding integrity is not maintained in an exercise trial.
The tension:
-psychedelics are pharmacological (lets set aside therapy for a sec), so blinding should work
-blinding obviously does not work due to strong subjective drug effects
Its an 'unblindable' pharma treatment (at least by conventional methods), which is strange at first
Read 7 tweets
In the @COMPASSPathway trial the 25mg vs 1mg (=placebo) #Psilocybin difference is not only significant statistically, but also clinically. On the MADRS the 'minimal important difference' is ~3-6 points (, the 25mg dose meets this criteria (more context 👇)
The 'minimal important difference' sounds like a low bar to cross, but actually most #antidepressants fail to do so relative to #placebo, - thank you @PloederlM for your work on this, would love to hear your take on this trial!
Lack of blinding remains an issue, but the dose-response relationship should alleviate this concern. As I argued before, #psychedelics macrodose trials most likely will always lack blinding due to obvious drug effects, it is the nature of the intervention.
Read 4 tweets
New article out now regarding the pharmacology of #psilocybin analogues including other compounds found in psilocybin-containing mushrooms, their active metabolites, and 4-acetoxy derivatives.…

#pharmacology #psychedelics #aeruginascin #baeocystin
This was truly an amazing team effort by many folks from @usonainstitute, @CaaMTechInc, @christophestove, Manke lab, Hulley lab, and NIDA IRP DDRU.

Keep an eye out for many more publications from us investigating the #pharmacology of #psychedelics !
Oh and I certainly can't forget to thank the NIMH PDSP for their role in these projects!
Read 3 tweets
“Chapter 9,” titled “To Save the World:

“Millennials...Psychedelics & Activism”

Quotes/Highlights THREAD

From *Culture War Class War 2022: Truth & Generations*

by Michael Adzema

(publishing 9/2022)

THREAD… #90s #Ecstasy #psychology #history

CW22Q 9/1
Quotes/Highlights THREAD

From *Culture War Class War 2022:

*Truth & Generations*

by Michael Adzema

(available on website now & to be published Sept 2022)

READ &/or dwl entire BOOK free AT SITE...

READ BOOK… #Millennials #90s #psychedelics

CW22Q 9/2
[Quotes/highlights:] “Not coincidentally, Millennial Generation parents were predominantly of the Vietnam Gen/ Boomers & Millennials echoed their parent’s more liberal & mind-expanding drug use.” []

THREAD…… #psychology #history #generations

CW22Q 9/3
Read 23 tweets
The 'default mode network' (#DMN) is the neurobiological poster child for #psychedelic #drugs (e.g., see #HowToChangeYourMind). A preliminary meta-analysis from the @PsychedelicUNIT suggests this might be overstated, w/ other regions being more impacted, like ye olde cerebellum. Image
These results are from 'classic' #psychedelics like #LSD and #psilocybin taken by healthy people during resting-state neuroimaging. We used dose as a covariate. A possible caveat is that we mixed blob and functional connectivity analyses which we will now try and model.
The details will soon be in a preprint and we will make the code and larger dataset publicly available. We hope this will help others to address their own questions with further meta-analyses. For example, we asked....
Read 8 tweets
1/5 If you’re enjoying @michaelpollan’s #HowToChangeYourMind on @netflix and want to go deeper on the science, here’s a list of #psychedelic readings authored by @DiamondThera advisors, collaborators and team members:
2/5 @DiamondThera advisor Dr. Torsten Passie’s book delves into the scientific literature on #microdosing. It covers tolerance, toxicity, and placebo and surfaces research that is often overlooked.…
3/5 A 360 review of available evidence on #psychedelic compounds’ effects on the pathways modulating neuroplasticity, immunity, and neurotransmitter systems. By @DiamondThera collaborators Dr. Gabriella Gobbi and Danilo De Gregorio.
Read 5 tweets
On July 21st, I’ll go LIVE on the #μltradelic podcast (@UltradelicHQ) to discuss @michaelpollan’s new @netflix series #HowToChangeYourMind. Why? #HTCYM clearly failed to address the growing #epidemic of #SexualAssault within the #psychedelic community. #MeToo

A Thread 🧵 ImageImageImage
2/ Back in May of last year, @michaelpollan publicly discussed his belief that there is “value” in “inoculating the public against inevitable negative stories” about #psychedelics including “sexual abuse in the treatment room” 🚩 🚩 🚩

Inoculate = make immune to, right? 🚩 🚩 🚩 Image
3/ In 1963, Bob Dylan poetically asked listeners across the globe

“How many times can a man turn his head and pretend that he just doesn't see? [...] How many ears must one man have before he can hear people cry? [...] The answer, my friend, is blowin' in the wind.”
Read 6 tweets
1/ @michaelpollan's highly-expected @netflix series #HowToChangeYourMind just premiered! 📺🍄 Despite near-universal praise, #HTCYM is rife with errors & borders on historical revisionism 🤥

A critique 🤔🧵 #LSD #MDMA #Peyote #Mescaline #Psilocybin #Mushrooms #Psychedelic @MAPS
2/ Before I get started, I'll give everyone a little bit of background information. @michaelpollan released a non-fiction work entitled "How to Change Your Mind" in May of 2018. Before the end of that year, his book about #psychedelic drugs became a @nytimes bestseller. Image
3/ @michaelpollan achieved massive coverage for this self-described "mental travelogue" of his #psychedelic experiences. Soon enough, Mr. Pollan became a prominent figure w/in the so-called "Psychedelic Renaissance". In the process, he gained a rather interesting reputation. Image
Read 104 tweets
Despite the importance of #blinding in medical research, most trials don't assess blinding integrity, partially because there is no method to adjust trial results for blinding integrity... until now! New preprint with implications for #microdose and #psychedelic research 🧪🧵👇
First, we define activated expectancy bias (AEB), which is an uneven distribution of expectancy effects between treatment arms due to patients recognizing their treatment allocation. AEB can be viewed as residual expectancy bias not eliminated by the trial’s blinding procedure.
The main idea behind AEB is that if treatment allocation can be deduced by participants, then, treatment expectancy can bias the outcomes in the same manner as it biases non-blinded trials, for example as in open-label trials. Image
Read 11 tweets
🧵Mind & Matter content series on @Leafly.

A written content series with a new article each month exploring the relationship between humanity and psychoactive drugs.

In this thread, I will collect links to each article in the series.

All articles:…

"Death and psychedelics: How science is reviving this ancient connection"

Explores the relationship between #psychedelics & death. It integrates the perspective of thinkers ranging from Timothy Leary to Aldous Huxley to @BrianMuraresku.

Read here:…

"Would psychedelic therapy work w/o tripping?"

Inspired by convos w/ scientists like David Nichols, @DEOlsonLab & others, explores the question of whether #psychedelics subjective effects are required for any of their therapeutic benefits.

Read here:…

Read 7 tweets
Today's @olof_rockner creation is a diagram designed to help show how I see and communicate with my Upsight Vision. Upsight is a form of visual consciousness, a layered network of moving images available to me when I turn my attention to them. #ufotwitter #aliens @LuAngeles 🧵1/ Image
This ability evolved after my encounter. I use my eyes to focus on Upsight images the same way you would use your vision to focus on a person walking across a room or catch sight of a bird flying past your window. 2/#uaptwitter #UFO #ufotwitter @ExoAcademian @UFO_Rabbit_Hole
I’ve broken Upsight into three levels for easier understanding. Lucid Dreaming, Remote Viewing, and Astral Projection/Abstract Knowledge. The first level, closest to my eyes in the diagram, represents lucid dreaming. 3/ #ufotwitter @the_jandashow #uaptwitter
Read 24 tweets
🧵"Psychoplastogens" = drugs that rapidly induce physical changes in the brain (neuroplasticity).

Examples: ketamine, psilocybin, LSD, DMT, MDMA.

Neuroscientists can literally watch new connections sprout overnight, as in the example below.


There are other plasticity-promoting psychoactive drugs, such as SSRIs, that are not psychoplastogens because they induce plasticity on a slower time scale (weeks).

Psychoplastogens can stimulate plasticity when exposed to neurons for <1 hour.…

I first learned about this term from the work of @DEOlsonLab.

I discussed his research with him in a recent podcast conversation, including his work on #psychedelics like ibogaine.

Listen here:

Read 6 tweets
This week #psychedelics, almost completely ignored by western science and medicine in the last quarter of the 20th century, made it to the top of 🇺🇸 healthcare, the @NIH:

4k folks 🌐 21 time zones
+10h of talks
Panelists from
🇺🇸 12
🇨🇦 1
🇮🇱 1
🇩🇰 1
🇬🇧 1
🇳🇿 1
🇨🇭 1

🧵 summary 👇
Agenda comprised 3 main themes:
Basic and translational research 🐀🔬👩‍🔬👨‍🔬🧮💻
Clinical trials 👩‍⚕️🧑‍⚕️👨‍⚕️🤮💊🤒💉
Optimising future trial designs 💾💽💿📀
Here are my remarks from 20y experience:
This is a good landmark to claim psychedelic science finally achieved maturity
Basic research is evolving rapidly and public funding 💰is what is needed to transform the field
Clinical trials suggest transdiagnostic safety and efficacy
Read 5 tweets
Third and last session of #psychedelics @NIH 🇺🇲 workshop starting now, looking at how to optimize clinical trials design and how to get these treatments approved 🧵
Starting with Ido @hartogsohn 🇮🇱 on psychedelic set and setting theory
Important Q ❓

Do we have an (excessively) costly and complicated drug regulation apparatus?
Read 19 tweets
Although some have speculated that #psychedelics produce enduring enhancements of cognitive flexibility, here we finally show that psilocybin therapy enhances cognitive and neural flexibility in major depressive disorder. However, there's a caveat. 1/10…
As previously reported, depression was reduced (…; see variability in single subject data provided here), but also cognitive flexibility (measured as a 𝑑𝑒𝑐𝑟𝑒𝑎𝑠𝑒 in perseverative errors) was enhanced 1 week post-psilocybin therapy. 2/10 Image
Similar to reductions in PCC glutamate 1 day post-ayahuasca (…) ACC glutamate was reduced 1 week post-psilocybin. We didn't see increased (static) functional connectivity between ACC and PCC but ACC-PCC dynamics of FC (neural flexibility) was increased. 3/10 Image
Read 10 tweets
🚨ALERT🚨 Medical professionals understand why it's misleading & unethical to say #psychedelics are a #cure for any health condition. In this @CNBC video, @C_Angermayer (@atai_life) says #ibogaine has the "potential to completely cure addiction" 🧵 1/8
Though it's true some patients in recent #psychedelic clinical trials did not meet diagnostic criteria for their treatment-resistant condition after therapy, many still felt lingering symptoms of their condition afterward. Unfortunately, #PsychedelicsArentSilverBullets. 2/8
Medical professionals understand the distinction between #cures and #treatments. The term cure "refers to a complete restoration of health". Treatments are reserved for medical interventions which aim to control symptoms (think "effective treatment”) 3/8…
Read 8 tweets
Post-#Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation 1/5…
#Psychedelic therapy shows promise as a novel intervention for a wide range of mental health concerns but its therapeutic action is incompletely understood. In line with acceptance and commitment therapy's (ACT's) transdiagnostic model, qual... 2/5
itative research has suggested that reductions in experiential avoidance are an important component of therapeutic outcomes associated with #psychedelics. However, limited research has quantitatively explored the association between decrease... 3/5
Read 5 tweets
#Psychedelics and virtual reality: parallels and applications 1/5…
#Psychedelic drugs and virtual reality (VR) each have the capacity to disrupt the rigidity and limitations of typical conscious experience. This article delineates the parallels among psychedelic and VR states as well as their potential syne... 2/5
rgistic applications in clinical and recreational settings. Findings indicate that, individually, #psychedelics and VR are used in analogous ways to alter sensory experience and evoke awe. They are also both used in tandem with traditional t... 3/5
Read 5 tweets
A mechanistic model of the neural entropy increase elicited by #psychedelic drugs 1/5…
#Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consc... 2/5
iousness. One of the most notable neurophysiological signatures of #psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousnes... 3/5
Read 5 tweets

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