A central, and perhaps the most avoided question is:

How many COVID deaths, (mostly of old people) is a price worth paying for a return to normality?
Noting however, that those who return to normality will have answered on behalf of others, who will actually pay the price
But also noting that many of those who will pay the price could have avoided doing so by getting vaccinated
And finally that the current price for our lifestyle in the US is about half a million COVID deaths per year. Let's hope that price comes down soon.

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More from @PaulBieniasz

12 Dec 21
Not the first, but a quite comprehensive analyses of Omicron neutralization resistance with @theodora_nyc, @NussenzweigL
Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups
By Fabian Schmidt, @FraukeMuecksch, Yiska Weisblum, Justin Da Silva, Eva Bednarski, Alice Cho @VinciZijun, @c_gaebler @marinacaskey
Link to full manuscript: drive.google.com/file/d/1zjJWsy…
We compared Omicron to an antibody resistant spike (PMS20) that we previously designed. Omicron distribution of changes and neutralization properties are similar to PMS20. Suggests that antibody evolutionary pressure drove Omicron emergence
Read 8 tweets
20 Sep 21
Our paper on #polymutant SARS-CoV-2 spikes (led by Fabian Schmidt and Yiska Weisblum with @theodora_nyc and @NussenzweigL) now published in @Nature
nature.com/articles/s4158…
rdcu.be/cx5qM
It shows that plasma antibodies target numerous epitopes in SARS-CoV-2 spike such that ~TWENTY mutations are needed for neutralization escape from polyclonal antibodies elicited by infection or vaccination.
Notably, antibodies from those who had been BOTH infected AND later vaccinated (2x mRNA), neutralized the #polymutant and as well as diverse bat/pangolin sarbecoviruses and SARS-CoV
Read 5 tweets
20 Jan 21
Our new preprint with @NussenzweigL @theodora_nyc and @bjorkmanlab

K417N, E484K and N501Y in SARS-CoV-2 “variants of concern” in UK, SA and Brazil are antibody escape mutations.
biorxiv.org/content/10.110…
Each confers resistance to commonly elicited RBD neutralizing antibodies cloned from mRNA vaccinees
Together, K417N, E484K and N501Y confer some (not complete) resistance to neutralization by vaccine recipient polyclonal plasma.
If we grow rVSV/SARS-CoV-2 with the cloned antibodies, most select for mutations at K417, E484 and/or N501.

Structures of vaccine-recipient antibodies with spike show K417, E484 or N501 are often in the epitopes of RBD-specific, vaccine elicited neutralizing antibodies
Read 8 tweets

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