Thread by @pfanderson

New research on #LongCovid a thread

"LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strategy pubmed.ncbi.nlm.nih.gov/35029046/ < proposes research on melatonin #LongCovid

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? pubmed.ncbi.nlm.nih.gov/35028901/ < suggests the spike protein enters the brain but protective antibodies do not #LongCovid

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection pubmed.ncbi.nlm.nih.gov/35027728/ "Patients w/ LC had highly activated innate immune cells, lacked naive T & B cells, showed elevated expression of type I IFN & type III IFN" #LongCovid

Aptamers Against COVID-19: An Untested Opportunity pubmed.ncbi.nlm.nih.gov/35023454/ #LongCovid

Does anti-viral treatment in acute COVID infection decrease the risk of developing the Long-COVID Syndrome? pubmed.ncbi.nlm.nih.gov/35020945/ < editorial #LongCovid

Exercise as a Moderator of Persistent Neuroendocrine Symptoms of Covid 19 pubmed.ncbi.nlm.nih.gov/35019862/ < I anticipate a comment/reply/rebuttal to this article from @LongCOVIDPhysio

Experiences of living with long COVID and of accessing healthcare services: a qualitative systematic review pubmed.ncbi.nlm.nih.gov/35017239/ | bmjopen.bmj.com/content/12/1/e… < fyi #medlibs an interesting methodology #LongCovid

Symptoms Experienced at the Acute Phase of SARS-CoV-2 Infection as Risk Factor of Long-term Post-COVID Symptoms: The LONG-COVID-EXP-CM Multicenter Study pubmed.ncbi.nlm.nih.gov/35017102/ < more symptoms during acute COVID = more symptoms post-COVID #LongCovid

Small Fiber Neuropathy and SARS-CoV-2 Infection. Another piece in the long COVID puzzle? pubmed.ncbi.nlm.nih.gov/35014706/ editorial notes dysautonomia can arise from a variety of neuropathway challenges, suggests using SFN screening tools early in recovery process #LongCovid

Premorbid vulnerability and disease severity impact on Long-COVID cognitive impairment pubmed.ncbi.nlm.nih.gov/35014002/ recommends early screening with Montreal Cognitive Assessment (MoCA) & better followup for discharged COVID patients #LongCovid

Orthopaedic long COVID - the unknown unknowns : are we facing a pandemic of avascular necrosis following COVID-19? pubmed.ncbi.nlm.nih.gov/35014543/ < delayed diagnosis and hip replacement surgeries may lead to ongoing health problems, creating pipeline challenges in orthopedics #LongCovid

Successful application of pulsed electromagnetic fields in a patient with post-COVID-19 fatigue: a case report pubmed.ncbi.nlm.nih.gov/35006516/ < ????? #LongCovid

Long COVID Mimicking Interstitial Lung Disease: A Case Series pubmed.ncbi.nlm.nih.gov/35003784/ "Long COVID should be a differential diagnosis to be considered while making a new diagnosis of ILD." #LongCovid

Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol pubmed.ncbi.nlm.nih.gov/34991703/ < protocol, not results #LongCovid

Hypotheses to explain the associations between asthma and the consequences of COVID-19 infection pubmed.ncbi.nlm.nih.gov/34978737/ "research is needed" #LongCovid

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis pubmed.ncbi.nlm.nih.gov/34973396/ "The frequency & debilitating nature of the symptoms provides impetus to characterize underlying neurobiological substrates & how to best treat" #LongCovid

Postural tachycardia syndrome and long COVID: an update pubmed.ncbi.nlm.nih.gov/34972793/ | bjgp.org/content/72/714… < POTS from Covid similar to POTS following other viral triggers #LongCovid

Facilitating care: a biopsychosocial perspective on long COVID pubmed.ncbi.nlm.nih.gov/34972801/ | bjgp.org/content/72/714… < Don't blame the patient for problems with the system. Modify info delivery to support patients

Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID - A multinational ICOSS study pubmed.ncbi.nlm.nih.gov/34964184/ < protocol paper #LongCovid

"Long COVID-19" of Researchers: What to Do Next? pubmed.ncbi.nlm.nih.gov/34964039/ editorial. It's frustrating trying to follow research on #LongCovid & finding all these articles using it as a metaphor of other kinds of pandemic sequelae

A clinical case definition of post-COVID-19 condition by a Delphi consensus pubmed.ncbi.nlm.nih.gov/34951953/ starts by 3mo after, lasts for 2 or more months, may relapse

Multisystem Involvement in Post-acute Sequelae of COVID-19 (PASC) pubmed.ncbi.nlm.nih.gov/34952975/ < 9 patients assessed for predominantly neuro sequelae.

Biomedical Perspectives of Acute and Chronic Neurological and Neuropsychiatric Sequelae of COVID-19 pubmed.ncbi.nlm.nih.gov/34951387/ < COVID may worsen neurological/neurocognitive deficits in folk who already have Alzheimers or Parkinsons #LongCovid

Levocetirizine and montelukast in the COVID-19 treatment paradigm pubmed.ncbi.nlm.nih.gov/34942461/ < small N study seemed to indicate this moderates severity, beginning larger study #LongCovid