Excited to share our story about an ancestral mutation in a #lncrna antisense of IGF1, that appeared over 50,000 years ago in #wolves, and that impacts modern #dogs and wild canids body size. It's out in @CurrentBiology. cell.com/current-biolog…
All thanks to my co-authors including @NicolasDubos @BevantKevin @ThomasDerrien7 @laurenhennelly1 @LrFrantz @Greger_Larson and the Ostrander lab @genome_gov
It is not only a #dog story, it is a #canid story.
An old allele associated with small size is shared between 13 different canid species.
A second allele, associated with large size, appeared in #wolves lineage, detected in a 54,000 years old #wolf.
An old allele associated with small size is shared between 13 different canid species.
A second allele, associated with large size, appeared in #wolves lineage, detected in a 54,000 years old #wolf.
It became the major allele in wolves, making them bigger than other canids, probably during the last ice age. However, the small allele never disappeared.
During the #domestication time, humans created the first small dogs using the ancestral small allele that still existing in wolves. We found it in a 9,500 year old dog sample. Today this small allele is the major allele in modern dogs, in 75% of small breeds < 15kg
We also show that the mutation is located within a #lncRNA, antisense of IGF1, sharing 182 bp in common, that we named IGF1-AS. We did not detect differential expressions for IGF1 and IGF1-AS between large and small #dogs, but we measured difference in IGF1 protein level in serum
We thus propose that IGF1-AS regulates #IGF1 translation rate. The exact mechanism is still under investigations from my side at @UnivRennes1 :) :)
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