1/ #UncleBob hopes those on the fence about vaccines will understand this
Weekly COVID-19 death rate via CDC:
Unvaccinated: 9.7 deaths per 100k
Fully vaccinated: 0.7 deaths per 100k
Boosted: 0.1 deaths per 100k
2/ Yes you can get omicron even if you are boosted
BUT
You are less likely to get infected
If you get infected you are much less likely to need hospitalization
If you need hospitalization, you are much less likely to need ICU care, and MUCH less likely to die
3/ Would you turn down medical care if you got sick?
I assume no - almost everyone comes to the hospital and ask for everything
Then why would you not accept a free prevention tool?
4/ If you get sick, others who do not have COVID are impacted. Surgeries are cancelled or postponed. Health care workers have to watch you die, knowing how unlikely that would be if you did get the vaccine.
5/ If you are worried about the vaccine, then ask yourself why have almost all physicians taken the vaccine. LIkely physicians know more about disease, vaccines and side effects than you do.
Please think about all these things. We would love for you to reconsider vaccination
• • •
Missing some Tweet in this thread? You can try to
force a refresh
2/ Learn to define and expand patient words - e.g., diarrhea (how often, what color, interfere with sleep, etc.). Patients describe things in words they understand, but often we interpret those words differently. Many such examples: chest pain, dyspnea, weakness, SOB, PND
3/ Try to understand the chronology and use that during presentation. This requires careful questioning so that the learner really understands the chronology.
2/ In the very first aliquot we learn that we have a college student with throat pain and chills. We do not know if they were simple chills or rigors. This is actually a BIG DEAL. Rigors (shaking chills) have a high odds ratio for bacteremia.
3/ If she really had rigors, then she needed blood cultures and admission for likely bacteremia. Interesting that she had unilateral tonsillar swelling. I have only seen this once in a patient with Fusobacterium tonsillitis with bacteremia! No data, just an observation
1/ #UncleBob is working to better understand hepcidin. Please critique this so that we can have a better understanding.
Hepcidin is a peptide hormone. Its main function is the regulator of iron entry into the circulation
2/ As hepcidin levels increase, iron transport into the circulation decreases. It does this by binding to ferroportin - the transport channel.
Thus - decreased dietary iron absorption. It also leads to iron sequestration in macrophages.
3/ Why should we care? IL-6 (a proinflammatory cytokine) stimulates hepcidin. Thus the anemia of chronic inflammation results from increased hepcidin which in turn makes iron less available to the bone marrow.
1/ #UncleBob asks you to consider the implications of the famous Nietzsche quote, “There are no facts, only interpretations” These tweets inspired by following @VPrasadMDMPH
We all interpret data differently weighing the risks & benefits.
2/ How else can one explain competing guidelines? Committees look at the same data and make different recommendations. This is the potential flaw in "evidence based medicine".
Confirmation bias influences all these decisions.
3/ The critical care community developed a very aggressive guideline for early treatment of possible sepsis. The ID community left the joint committee and wrote a strong editorial about the risk of over use of antibiotics secondary to this guideline.