Pain is a lived experience of the person in a world. Considering anything less to explain the experience misunderstands the reality.
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Ideas of training the brain follow from the reductionist and dualist viewpoint. Both are limited and out of step with modern models—enactivism and predictive processing.
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The brain is changing all the time anyway. Neuroplasticity fits with impermanence—constant change. Neuroscience is the study of neuroplasticity. There’s nothing special about neuroplasticity when it comes to pain beyond any other experience.
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It is the person who eases and transforms suffering, often needing guidance and encouragement. Whilst the brain is important, there is much more to consider.