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The Fromm Lab

Feb 2 • 5 tweets • 4 min read

@UiTNorgesarktis

Please RT:
Looking for a computational PostDoc to join our lab @UiTNorgesarktis in beautiful Northern Norway through the Artic Marie-Curie PostDoc program (uit.no/project/arctic…).

Apply by 25th of February.

#academicjobs #postdocs #microRNA #scRNAseq
tinyurl.com/2p8uewx3

Successful applicants will be invited to Tromsø (travel and accommodation expenses covered) for a three-day MSCA-PF symposium June 8-10, 2022 (if pandemic allows).

At this event, the candidates will present their past research achievements, discuss future plans with their potential supervisor, and learn how to write a successful MSCA-PF application.

(see: uit.no/nyheter/forske… the lab's current projects / latest publications)

The selected candidates will, jointly with the supervisor, write the MSCA-PF application by the deadline of September 14, 2022.

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The Fromm Lab

@BastianFromm

Jan 15

@HyeEirik

Very happy to see our microRNA metastases paper out. co-led by @HyeEirik and by many fantastic colleagues

We show the reasons for previously published contradicting reports of de-regulated #microRNAs in colorectal cancer #tumors and #metastases:

tinyurl.com/yckwdk2z

Among them are
- lack of correction for background expression
- different metastatic sites were not analyzed as separate entities
- expression cut-off level for microRNAs to ensure biological relevance are typically not used

We establish a stringent, reproducible and easily expandable bioinformatics pipeline (github.com/eirikhoye/mirn…) that we applied on all previously published (depending on availability) and a large range of novel smallRNA sequencing datasets, altogether 268 datasets.

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The Fromm Lab

@BastianFromm

Feb 16, 2021

@RNAJournal

Final version of our Ancient microRNA paper out with @RNAJournal out today. We are very happy to see our manuscript online and hope you all enjoy it as we do :-).
A thread on RNA from 14 000 year old samples 1/6
#Paleotranscriptomics rnajournal.cshlp.org/content/27/3/3…

When reading the great study by Smith et al on the #Tumatpuppy ancient RNA sequencing that used a smallRNA sequencing protocol, we immediately thought to dig deeper in their data for #microRNAs. 2/6 journals.plos.org/plosbiology/ar…

@CpgSthlm

Teaming up with them and @CpgSthlm (@love_dalen), we found microRNAs that showed abundances and nucleotide damage patterns (!) comparable to what had been described from historic, but never before from such ancient, >14 000yrs old RNA samples 3/6

Read 7 tweets

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