Thread by @davidasinclair

Turning up the fruit fly Sirt6 gene slows 🪰 aging and extends lifespan, just as in 🐭 and possibly 👩🏻, apparently by mimicking fasting and slowing protein production
🪰 pnas.org/content/119/5/…
🐁 pubmed.ncbi.nlm.nih.gov/34050173/
👩🏻 tinyurl.com/ytb63s7t

The above is a mortality curve, with % of the fly population still alive each day

Companies are in a race to make therapies that a turn up Sirt6 to treat cancer, metabolic diseases and inflammation. Might make an announcement soon 🙊
longevity.technology/gene-therapy-u…

The blue line is the population of flies that has Sirt6 turned up compared to the population in black that doesn’t

Sirt6 is one of seven Sirtuin enzymes in our cells that use NAD to promote longevity. It repairs broken DNA and controls genes involved in energy metabolism, cancer & inflammation. It’s a rare longevity gene that works in a wide variety of species