Tweet

David A. Sinclair

5 Jan, 12 tweets, 5 min read

@hubermanlab

Episode 1 of the Lifespan Podcast is out, to provide access to the latest science and tech to lengthen healthy life. Big thanks to @hubermanlab @mdlaplante @R_Mohr tinyurl.com/2p8f4ymc 1/11...

Apple: podcasts.apple.com/us/podcast/lif…
Spotify: open.spotify.com/episode/4YzixV… 2/11

@mdlaplante

In this episode, @mdlaplante and I discuss why we age. We talk about which organisms have extreme longevity and how, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging...3/11

...the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" & "chronological age" and how we can measure biological age through DNA clocks 4/11

Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins...
5/11

00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"...
6/11

00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths
01:01:55 Options for Subscription and Support...
7/11

Title Card Photo Credit: Mike Blabac - blabacphoto.com 8/11

Links provided to source material every episode
Weapon fragments in bowhead whales - bit.ly/3eP7rqP
Rapamycin extends lifespan in mice - go.nature.com/3F0yud3
Targeting Aging with Metformin (TAME) Trial - bit.ly/3eU9ABk 9/11

Metformin improves healthspan and lifespan in mice - go.nature.com/3JSRZbs
Metformin reduces all-cause mortality - bit.ly/3pWNiWc
Reprogramming to restore vision - go.nature.com/335iysI
DNA methylation age - bit.ly/3sUAUYB 10/11

Genome-wide methylation profiles & human aging rates - bit.ly/3ETPXnK
First reversal of epigenetic aging in humans - bit.ly/3eUior3
Danish twins longevity genes vs lifestyle study - bit.ly/3eToU13 11/11

I really hope you enjoy this series. My team and I will continue to research and present the most interesting and potentially efficacious approaches to staying healthy & living longer. Feedback on content is always welcome as we plan Series 2

• • •

Missing some Tweet in this thread? You can try to force a refresh

This Thread may be Removed Anytime!

Twitter may remove this content at anytime! Save it as PDF for later use!

More from @davidasinclair

David A. Sinclair

@davidasinclair

2 Dec 21

@InsideTracker

According to @InsideTracker, my blood biomarkers have been steadily approaching a much younger person’s over the past decade. Can’t wait to see my latest results

@chefserenapoon

For the past dozen years, I have avoided desserts & taken supplements, based on hard science. But I couldn’t break through the love-handle weight barrier. With inspiration from @chefserenapoon, I’ve optimized my diet for longevity & reached my 20 yr old weight again 💪🙏

If I can do it, anyone can. And it’s important. Only 20% of our future health is genetic. 80% is in our own hands

Read 4 tweets

David A. Sinclair

@davidasinclair

28 Nov 21

Having a positive attitude seems to boost immunity & even slow aging. But how? New study 🐭 shows neurons in the insular cortex increase the number & activity of immune cells in the gut & around organs. Breakthrough!👇1/6

tinyurl.com/bdcvdmcs

150 years ago it was discovered that presenting patients allergic to pollen with an artificial flower is sufficient to induce an allergic response (Mackeszie, 1886) 3/6

Read 6 tweets

David A. Sinclair

@davidasinclair

20 Nov 21

This Thanksgiving, give your parents a huge hug. When you graduated from high school, you’d used up 93% of the face time you’ll ever have with your parents. We will extend this time, but, for now, give them a huge hug waitbutwhy.com/2015/12/the-ta…

@waitbutwhy

Tips from Tim Urban @waitbutwhy
1. Living in the same place as the people you love matters. I probably have 10X the time left with the people who live in my city as I do with the people who live somewhere else. 2/5

2. Priorities matter. Your remaining face time with any person depends largely on where that person falls on your list of life priorities. Make sure this list is set by you—not by unconscious inertia. 3/5

Read 5 tweets

David A. Sinclair

@davidasinclair

15 Nov 21

If you ingest antioxidants, consider this: Free radicals (ROS) activate immune cells that kill cancer. Explains the anti-tumor effect of METFORMIN, a type 2 diabetes drug that may also slow aging 💪 1/ eurekalert.org/multimedia/807…

MitoTEMPO, an antioxidant scavenger of mitochondrial superoxide, abolished the antitumor effect of METFORMIN in mice. Maybe regular anti-oxidants, such as vitamin C, prevent METFORMIN from inhibiting cancer... 2/

@SciReports

The MitoTEMPO data suggests METFORMIN's anti-cancer effect stems from mitochondrial ROS ->"mitohormesis"⚡️You can also induce mitohormesis via EXERCISE (⬇️O2) or hyperbaric O2 therapy (⬆️O2). Does HBOT slow cancer? Yep! This 2021 paper @SciReports nature.com/articles/s4159…🌪️ 3/

Read 6 tweets

David A. Sinclair

@davidasinclair

13 Nov 21

Matcha, or Japanese ceremonial green tea, is one of the world’s healthiest drinks. Not because of antioxidants but survival molecules that Camillia sinensis makes when grown in the shade. When we ingest them, they boost our survival enzymes to fight aging & disease 💪 1/7

We’ve named these special plant defense molecules “Xenohormetins” 🌱 Xeno for between species, hormesis for what doesn’t kill you makes you stronger 🏃‍♀️ cell.com/cell/fulltext/… 2/7

When we ingest xenohormetins, they turn up survival defense enzymes such as Sirt1 and AMPK, known targets of resveratrol and metformin derived from grape vines and French lilac, respectively 🍷 3/7

Read 9 tweets

David A. Sinclair

@davidasinclair

9 Nov 21

In 1963, when 👩‍🔬👨‍🔬 thought free-radical damage to DNA caused aging, Smith et al. were studying wasp aging 🐝 Their unexpected results made them ask “if DNA mutation does not explain aging, what other mechanism could be involved?” Cue da epigenome… journals.uchicago.edu/doi/abs/10.108…