1/ Several implications of this mask study:

- N95 well-fit should protect 99%.

The lower 83% in the real world likely in part due to LEAKS and POOR FIT

Shows room for improvement of fit (N95 w/ straps behind head better than ear loop ones like KN95). Make sure tight to face
2/ Also likely impact of fake KN95 that don't filter well.

Don't buy KN95 on Amazon, full of fakes. Buy from reputable safety suppliers

Korean KF94 better, few fakes

[Of course there could also be a few % of transmission thru eyes or other minor pathways + "experiment noise"]
3/ IMPORTANT that the reports are the 1-way protection in same indoor environments.

If everyone wears similar masks, the we get (approx.) the effect SQUARED

17% of virus escape infected (100-83). And 17% of virus in air is inhaled. So prob. Of infection 0.17^2 = 3% vs. no mask
4/ So comparison if EVERYONE:

- No mask: 100%
- Cloth mask: (1-.56)^2 = 19%
- Surgical: (1-.66)^2 = 12%
- N95 / KN95: 3%

Same math as this @PNASNews study:
pnas.org/content/118/49…
5/ Let's state the results another way:

Compared with everyone wearing N95 / KN95, the probability of infection is:

- 4 times larger if all surgical
- Over 6 times longer if all cloth
- Over 35 times higher if all unmasked

Huge effects
6/ To state it another way for the "my freedom" crowd:

- If we all wore N95/KN95, we could spent 4 times longer in indoor activities than if all surgical

- 6 times longer than if all cloth

- 35 times longer than unmasked

[For the same risk]

So GOOD MASKS GIVE US FREEDOM!
7/ Now, these results are with lots of fake KN95 out there, and with very poor @CDCgov communication about the importance of N95 and mask fit

We should be able to do better & improve the results substantially, if govts. provide good quality N95 (not KN95) and explain fit better
8/ Also important: spread of virus is EXPONENTIAL.

Those transmission reductions are in 1 GENERATION of infection (every ~4 days)

Like compound interest, they accumulate exponentially

Imagine if the bank told you they are going to increase your loan interest RATE x4 or more!
9/ Good point that the remaining transmission w/ N95 may not all be leaks and fakes, but also some transmission at home w/o masks

Numbers are noisy, and there are confounders in both directions

But trend is very clear and consistent w/ real mask tests.

10/ Although note that people who wear N95 / KN95 are less likely to bring the virus home, and thus less likely to infect people there.

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More from @jljcolorado

Feb 2
This webinar on the "Science and History of COVID Transmission" starts in 20 minutes

Thanks for the Univ. of Philippines, @JoshuaCAgar and many other colleagues for the invitation

[2nd one next week]

It can be viewed online (or later) at those YouTube and Facebook Live links
The slides that I will show are here:

tinyurl.com/COVID-Aerosols…
This is the live video in Facebook Live:

facebook.com/watch/live/?re…
Read 7 tweets
Jan 31
1/ Yesterday I debated a Philippines govt. expert, @EdselSalvana

Reasonable debate, although he REFUSED to debate in person

But he ended it with this LOGICAL FALLACY: an appeal to authority

This has been SO common in this pandemic, that I'll explain it in a thread
2/ The pandemic is a really complex problem, which needs input from many disciplines. NOT only from clinical researchers / practitioners.

Other medical doctors are more open minded, see from @Bob_Wachter, prominent expert from @UCSFHospitals (>1 yr ago)

@Bob_Wachter @UCSFHospitals 3/ Among the disciplines @bob_wachter cites, MANY are non-medical. Clinical medicine is 1 of them. So is AEROSOL SCIENCE

Clinicians treat ppl w/ virus INSIDE body. Aerosol sci. studies virus OUTSIDE body

Need to work together, NOT claim supremacy of 1, ignore the other
Read 30 tweets
Jan 29
1/ The error conflating short-range airborne transmission (aerosol inhalation) with large droplet (sprayborne) transmission is alive an well in this Facebook post from a Philippines Government advisor:

[Can't reply there, so I will here]
2/ He is strangely defining airborne as ONLY long range. That makes no sense.

The protection measures depend on the mechanism, NOT ON THE DISTANCE.

3 key mechanisms per @CDCgov
(1) Aerosol inhalation
(2) Large droplet spray
(3) Surface touch

cdc.gov/coronavirus/20…
3/ It is clear that aerosol inhalation, i.e. airborne transmission (at ALL DISTANCES) is the dominant mode of transmission. There is overwhelming evidence of this, e.g.:

Read 9 tweets
Jan 28
1/ @Nature: "COVID-10: endémico NO significa inofensivo"

"La palabra 'endémica' se ha convertido en una de las peor utilizadas de la pandemia. Y muchas de las suposiciones erróneas fomentan una complacencia fuera de lugar"

Por virólogo @ArisKatzourakis

www-nature-com.translate.goog/articles/d4158…
2/ "Una enfermedad puede ser endémica, generalizada y mortal. La malaria mató a más de 600.000 personas en 2020. 10 M enfermaron de tuberculosis ese mismo año y 1,5 M murieron. Endémico ciertamente no significa que la evolución haya domesticado de alguna manera un patógeno"
3/ Existe una idea errónea generalizada y optimista de que los virus evolucionan con el tiempo para volverse más benignos. Este no es el caso: no existe un resultado evolutivo predestinado para que un virus se vuelva más benigno..."
Read 8 tweets
Jan 24
1/ A big COVID outbreak takes 2 ingredients:

- someone highly infective (most infected people don't seem to be infective or little; the highly infective are so during a short period)

- The right indoor conditions for accumulating and breathing in the virus.
2/ In this paper we showed that the outbreaks that have complete data for analysis are explained by airborne transmission in shared indoor air

[Detailed explanation on that thread]

3/ The level of virus in the air is analogous to the level of water in a sink, depends on:

- faucet: emission rate of virus

- size of sink: volume of room

- size of drains: ventilation, filtration etc.

[Analogy not perfect but good for illustration]

Read 13 tweets
Jan 24
1/ @Nature: "COVID-19: endemic doesn’t mean harmless"

"The word ‘endemic’ has become one of the most misused of the pandemic. And many of the errant assumptions made encourage a misplaced complacency."

By @ArisKatzourakis

nature.com/articles/d4158…
2/ "A disease can be endemic and both widespread & deadly. Malaria killed more than 600,000 ppl in 2020. 10M fell ill with tuberculosis that same year & 1.5M died. Endemic certainly does not mean that evolution has somehow tamed a pathogen so that life simply returns to ‘normal’"
3/ "There is a widespread, rosy misconception that viruses evolve to become more benign. This is not the case: there is no predestined evolutionary outcome for virus to become more benign, especially ones, such as SARS-CoV-2, in which most transmission happens bf severe disease"
Read 6 tweets

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