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Feb 7 • 4 tweets • 2 min read
Some evidence suggesting that #LongCovid patients might be more susceptible to breakthrough infections:

1/
“The team found that [LC patients have more autoantibodies], & that as autoantibodies increase, protective SARS-CoV-2 antibodies decrease. This suggests a relationship between #LongCovid, autoantibodies and patients at elevated risk of re-infections.” 2/

bloomberg.com/press-releases…
“Many patients with high autoantibodies simultaneously have low (protective) antibodies that neutralize SARS-CoV-2, and that’s going to make them more susceptible to breakthrough infections,” said Daniel Chen, a co-first author of the paper.” #LongCovid

3/
Published paper here (same one as the EBV reactivation paper from recently): cell.com/cell/pdf/S0092… 4/

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More from @ahandvanish

Hannah Davis Profile picture
Feb 4
Thank you to Mike for this piece on our #LongCovid work at @patientled & @itsbodypolitic in the context of what we're up against: a long history of medical gaslighting. Many illnesses (AIDS, cancer, MECFS, colitis, MS) were dismissed before their biomedical cause is found. 1/
The toll of doing advocacy in this environment is high (for us now, & also everyone who came before us).

It's been hard for me to be this vulnerable about this experience so extra thanks to @mikesmariani - a #pwME himself - for treating this topic with grace. 2/
The gaslighters are loud, but they're a minority. And they are quickly being shown to be not just historically cliched, but medically wrong, given how much #LongCovid research is already available. 2 years into this we already have evidence of...

3/
Read 7 tweets
Hannah Davis Profile picture
Feb 1
Thank you so much to @RepPressley for meeting with leaders of the #LongCovid & disability community to talk about major treatment, research, and policy needs, and her call to the CDC to #CountLongCovid!

Our full conversation is available here:

1/
Thank you to all the advocates (representing @patientled, @itsbodypolitic, @C19LH_Advocacy, @UTc19LongHaul & others) who spent energy giving amazing testimonies: @LisaAMcCorkell, @chiluvs1, @netiamccray, @LisaOBrienn, @SeeMiaRoll, @K_Bishof, @rubyslippahs, @annwlace409 & Molly 2/
A thing that stood out to me: Dr. Bateman (1:02:59), who spent her career seeing v disabled ME patients, saying:

"I was completely stunned by the disability & severity of illness in #LongCovid...the amount of cognitive impairment & physical impairment is just unbelievable."

3/
Read 6 tweets
Hannah Davis Profile picture
Jan 5
Getting an illness that has been unnecessarily politicized is a nightmare.
I don’t want to deal with trolls and harassment for making threads about biomedical papers.
(and obviously there are many politicized illnesses, #LongCovid is just one. but one everyone wants to have an opinion on)
Read 4 tweets
Hannah Davis Profile picture
Jan 5
New, very strong, meta-analysis published on 81 studies estimating #LongCovid prevalence!

Key findings:

32% of patients have fatigue at 12 weeks, 31% at 6+ months
22% have cognitive impairment at 12 weeks, 21% at 6+ months

Lots of additional info:

1/
 sciencedirect.com/science/articl…
It focuses on 2 most common & debilitating #LongCovid symptoms: fatigue & cognitive impairment. Unlike other studies which don't include cognition or only include 1 impairment (i.e. difficulty concentrating), this includes memory & more comprehensive cognitive symptoms.

2/
A really key finding is that fatigue and cognitive impairment were not statistically significantly different between hospitalized and non-hospitalized patients!

This is a major point as the public assumes that non-hospitalized cases are "mild".

#LongCovid

3/
Read 10 tweets
Hannah Davis Profile picture
Dec 23, 2021
This week marks the 1 year anniversary of @patientled's 2nd #LongCovid paper (now peer-reviewed & published: thelancet.com/journals/eclin…).

The good news: it got better information to many new researchers, including the accurate symptoms, neurological severity, & testing issues.
1/
It has over 200k views & several hundred citations, & informed policy in many countries & orgs, including the US, UK, Belgium, Spain, the WHO, CDC, & others.

The bad news:

2/
Most of this info is still not common knowledge to the general public & new patients. So many have no knowledge that cognitive dysfunction, memory issues, neurological issues, post-exertional malaise, dysautonomia (incl temperature & heart issues), & more are SO COMMON.

3/
Read 7 tweets
Hannah Davis Profile picture
Nov 30, 2021
Exciting paper on endothelial dysfunction (ED) in #LongCovid! (Endothelium is a membrane that lines blood vessels).

"Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction."

frontiersin.org/articles/10.33…

Some key points:

1/ Image
-Endothelial dysfunction (ED) is associated with high cholesterol!
-3 symptoms were associated with ED: fatigue, cognitive dysfunction, & shortness of breath. Others, including loss of sense of smell & cough, were not!

#LongCovid

2/ Image
-Reduced Left Ventricle GLS (Global Longitudinal Strain) was associated with #LongCovid (which I believe validates findings from @PutrinoLab et al?)
-There's a note that beta blockers were associated with reduced Long Covid symptoms

3/
Read 6 tweets

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