Caloric restriction (CR) may extend lifespan. People who did 14% CR for 2 yrs had gene expression changes in fat incl. NAMPT, which makes NAD, and Pla2g7. In mice, deletion of Pla2g7 reduced inflammatn & kept the immune system young, pointing to new drugs tinyurl.com/4nd8tyx6
The gene expression changes were similar to effects of bariatric surgery and exercise and included nutrient sensing, inflammation and longevity
The data from this human study are also relevant regarding controversies emerging from animal studies that questioned CR’s effects on health and inflammation
Aging of thymus precedes aging of other organs, a process characterized by increased thymic lipid accumulation and loss of T cell production. Compared with baseline, sustained CR for 2 years significantly increased thymic mass as well as total thymic volume
Collectively, these “findings demonstrate that sustained CR in humans activates a core transcriptional program that promotes immune function, reduces inflammation, and reveals PLA2G7 as one of the potential mechanisms to mimic the beneficial effects of CR.”
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The above is a mortality curve, with % of the fly population still alive each day
Companies are in a race to make therapies that a turn up Sirt6 to treat cancer, metabolic diseases and inflammation. Might make an announcement soon 🙊 longevity.technology/gene-therapy-u…
Ignore the clickbait title - here’s a well researched article about real companies working on age reversal to treat real diseases 1/n @NatureBiotech@sciamtinyurl.com/yckpbmb4
Space is red 🔥. Companies highlighted: 2/n
“Multiple companies have sprung up to build on these pioneering studies: Sebastiano co-founded Turn Bio, Sinclair set up Life Biosciences, & Izpisúa Belmonte has joined Altos Labs.” 3/n
Risk of multiple sclerosis increases 32-fold after infection with Epstein-Barr virus (which causes Mono). These findings cannot be explained by any other risk factor and suggest EBV as the leading cause of MS 1/n
Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses @CDCgov 2/n
Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva 3/n
Reducing spikes in blood glucose is considered healthy in the long run. In mice, the drug Acarbose blunts the spike & they live 4-17% longer 🐭 Consider eating some protein before carbs, reduce sugar and avoid high “GI” foods like rice and bread. Refs + more info👇
Seek whole grains, nuts, legumes, vegetables without starch. Avoid high glycemic index (GI) foods, like potatoes, white rice, white bread, and eat fewer sugary foods, including candy, cookies, cakes, and regular sodas. I gave up dessert at 40, though I do steal tastes 🍰 👅 3/n
Lp(a) is a type of cholesterol that is the strongest genetic risk factor for heart disease. In Canada and Europe, a test is recommended for everyone, but not in the US, even though it could inspire those at risk to live healthier. 1/8 tinyurl.com/46reumcc
There are no effective drugs to treat high LP(a) but removing it from the blood stream using apheresis in high-risk patients can dramatically reduce major coronary events 2/8
In the LPA gene there is a repetitive part called kringle IV, lower numbers of which lead to increased Lp(a) concentrations (I have the bad version btw) 3/8
In this episode, @mdlaplante and I discuss why we age. We talk about which organisms have extreme longevity and how, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging...3/11