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Eric Feigl-Ding Profile picture
@DrEricDing
Feb 18, 2022 • 14 tweets • 10 min read • Read on X
⚠️Worrisome—New lab experiments from Japan show that #BA2 may have features that make it as capable of causing serious illness as older variants–including Delta! And yet as evasive as old #Omicron cousin BA1. #BA2 🌍 surging—needs upgrade to VOC asap @WHO!
cnn.com/2022/02/17/hea…
2) BA2 is seriously bad news. It’s both faster transmission than BA2 and if it’s truly more severe and as evasive against prior immunity including BA1 old #Omicron immunity— then it’d be the worse of 4 worlds. 👀
3) Faster is bad. Very bad. Hard to imagine faster than old Omicron — yet here we are!!! 🤦🏻‍♂️
4) Resistant to Omicron BA.1 induced immunity. Being BA1 immune from past infection provided immunity against BA1– ➡️ but significantly less against BA2. 👀

Good thing we aren’t dropping mitigations anywhere right??? 🤦🏻‍♂️ Image
5) for vaccine evasion- BA2 is similar to BA1 albeit both are MUCH more evasive than Delta. Boosters still good ~70-74% VE for symptomatic infection. But not enough people boosted. biorxiv.org/content/10.110… Image
6) just how fast is BA2??? It’s now 90% of all #COVID in Denmark. And there’s even two different BA2 versions! Red and blue below. The red H78Y is surging even more 👀

Ht @DrWilliamKu Image
7) Let’s look at it this way—BA2 is much more aggressive than anything —both pink and green below are BA2 — but the green H78Y subtype of BA2 extra aggressive it seems. Meanwhile BA1 old Omicron near extinct in 🇩🇰! That doesn’t happen by chance. We need to raise BA2 as VOC asap! Image
8) here is what is happening in the country with the most #BA2 variant so far.., 🇩🇰 has been BA2 dominant for weeks and have now almost no mitigations either… now their excess deaths are spiking again…
9) "[#BA2] might be, from a human's perspective, a worse virus than BA.1 and might be able to transmit better and cause worse disease," says Dr. Daniel Rhoads, section head of microbiology at the Cleveland Clinic in Ohio. BA2 needs a new designation now!!!
10) Worse— monoclonal antibody drug now fails against #BA2 VARIANT—one of the last monoclonal antibody drug still available fails—the rapidly spreading #Omicron BA.2 sublineage "exhibited marked resistance" to sotrovimab in lab experiments. Shit.

medscape.com/viewarticle/96…
11) Meanwhile, we know #BA2 is also surging fast in the US. CDC needs to update its BA2 data — it’s been almost 2 weeks with no new data released!! C’mon @CDCgov - release the new BA2 numbers. The world is watching @CDCDirector
12) Even the @WHO is getting very concerned about #BA2 variant outcompeting and displacing old #Omicron. WHO’s COVID lead @mvankerkhove now warns about a likely BA2 related surge. We must be vigilant. This is not a drill—BA2 is real.

HT @Cleavon_MD.
13) we must act quickly with high urgency to stop the rise of BA2. We have not learned from the past — if we ignore BA2, we could be facing another / continued wave of excess deaths. Let’s learn from history rather than repeat it. 🙏
14) The other urgency is that vaccine effectiveness is only high with boosters in face of #Omicronc whether BA1 or BA2. But most folks aren’t boosted in most countries. Thus are we truly prepared for #BA2 given we know BA1 infection immunity isn’t as good versus BA2? #GetBoosted

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Eric Feigl-Ding Profile picture
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Eric Feigl-Ding Profile picture
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets

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