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Eric Feigl-Ding Profile picture
@DrEricDing
Feb 18, 2022 • 14 tweets • 10 min read • Read on X
⚠️Worrisome—New lab experiments from Japan show that #BA2 may have features that make it as capable of causing serious illness as older variants–including Delta! And yet as evasive as old #Omicron cousin BA1. #BA2 🌍 surging—needs upgrade to VOC asap @WHO!
cnn.com/2022/02/17/hea…
2) BA2 is seriously bad news. It’s both faster transmission than BA2 and if it’s truly more severe and as evasive against prior immunity including BA1 old #Omicron immunity— then it’d be the worse of 4 worlds. 👀
3) Faster is bad. Very bad. Hard to imagine faster than old Omicron — yet here we are!!! 🤦🏻‍♂️
4) Resistant to Omicron BA.1 induced immunity. Being BA1 immune from past infection provided immunity against BA1– ➡️ but significantly less against BA2. 👀

Good thing we aren’t dropping mitigations anywhere right??? 🤦🏻‍♂️ Image
5) for vaccine evasion- BA2 is similar to BA1 albeit both are MUCH more evasive than Delta. Boosters still good ~70-74% VE for symptomatic infection. But not enough people boosted. biorxiv.org/content/10.110… Image
6) just how fast is BA2??? It’s now 90% of all #COVID in Denmark. And there’s even two different BA2 versions! Red and blue below. The red H78Y is surging even more 👀

Ht @DrWilliamKu Image
7) Let’s look at it this way—BA2 is much more aggressive than anything —both pink and green below are BA2 — but the green H78Y subtype of BA2 extra aggressive it seems. Meanwhile BA1 old Omicron near extinct in 🇩🇰! That doesn’t happen by chance. We need to raise BA2 as VOC asap! Image
8) here is what is happening in the country with the most #BA2 variant so far.., 🇩🇰 has been BA2 dominant for weeks and have now almost no mitigations either… now their excess deaths are spiking again…
9) "[#BA2] might be, from a human's perspective, a worse virus than BA.1 and might be able to transmit better and cause worse disease," says Dr. Daniel Rhoads, section head of microbiology at the Cleveland Clinic in Ohio. BA2 needs a new designation now!!!
10) Worse— monoclonal antibody drug now fails against #BA2 VARIANT—one of the last monoclonal antibody drug still available fails—the rapidly spreading #Omicron BA.2 sublineage "exhibited marked resistance" to sotrovimab in lab experiments. Shit.

medscape.com/viewarticle/96…
11) Meanwhile, we know #BA2 is also surging fast in the US. CDC needs to update its BA2 data — it’s been almost 2 weeks with no new data released!! C’mon @CDCgov - release the new BA2 numbers. The world is watching @CDCDirector
12) Even the @WHO is getting very concerned about #BA2 variant outcompeting and displacing old #Omicron. WHO’s COVID lead @mvankerkhove now warns about a likely BA2 related surge. We must be vigilant. This is not a drill—BA2 is real.

HT @Cleavon_MD.
13) we must act quickly with high urgency to stop the rise of BA2. We have not learned from the past — if we ignore BA2, we could be facing another / continued wave of excess deaths. Let’s learn from history rather than repeat it. 🙏
14) The other urgency is that vaccine effectiveness is only high with boosters in face of #Omicronc whether BA1 or BA2. But most folks aren’t boosted in most countries. Thus are we truly prepared for #BA2 given we know BA1 infection immunity isn’t as good versus BA2? #GetBoosted

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More from @DrEricDing

Eric Feigl-Ding Profile picture
May 2
Incredibly frustrating that the @USDA again failed to include basic information about H5N1 genetic sequences from cows. All data had dates and locations scrubbed out—only saying “USA” & “2024”, which is useless for scientists to analyze for mutation rates.
statnews.com/2024/05/02/bir…
Image
2) The fact that basic information — called metadata — isn’t being shared about the samples “hinders our efforts a lot,” said Gytis Dudas, a senior researcher in genomic epidemiology and metagenomics. Dudas is working with a group of U.S. and international researchers to try to make sense of what the genetic sequences say about the H5N1 outbreak in cows.
3) A number of scientists have openly questioned whether the USDA is deliberately withholding these data, or even removing more specific information. 🔥
Read 5 tweets
Eric Feigl-Ding Profile picture
Apr 27
⚠️CDC WARNING FOR ALL VETERINARIANS, POULTRY, DAIRY & CATTLE FARMWORKERS, SLAUGHTERHOUSE WORKERS—New CDC guidelines now released to use PPE for high risk bird flu exposure occupations (all recommended):

📌N95 respirators
📌Goggles 🥽 or face shield 🛡️
📌Coveralls or fluid-resistant aprons
📌Head covering
📌Rubber boots with sealed seams
📌Gloves

Furthermore:
📍Designated areas for changing PPEs
📍Do not eat, drink, chew gum, chew tobacco, smoke, vape, or use the bathroom while wearing above PPE
📍Shower after work shift
📍(see full list for more details).

Glad the @CDCgov is taking this seriously. You should too. And please don’t drink raw milk 🥛! #AvianFlu #BirdFlu #H5N1
cdc.gov/flu/avianflu/h…Image
Image
Image
Don’t do raw milk 🥛 please, for the love of god. I know there are many raw milk enthusiasts out there. But just take a pause until this is over? Don’t try to be a macho man about this.
3) try to drink either vegan milks like oat or soy or almond milk, or ultra pasteurized milk.
Read 9 tweets
Eric Feigl-Ding Profile picture
Apr 27
Seriously. Raw milk drinkers… don’t do it. We scientists are pretty damn sure there will be some degree of active virus inside raw milk. Cats have been infected on farms—via likely raw milk. And all 6 cats with bird flu have died of rapid neurological declines, says CDC.
Raw milk drinkers… 1% of all milk being non pasteurized worries me. Too much virus to be potentially circulating.
3) I’m sticking with either vegan types of milk, or ultra pasteurized just to be safe.
Read 6 tweets
Eric Feigl-Ding Profile picture
Apr 26
⚠️Bad signal—CDC confirming—“cats having neurologic symptoms, rapid decline, and death” from H5N1 #birdflu. 3 more cases in cats 🐈 on dairy farms… now 6 total. ➡️The prior 3 bird flu positive cats? All dead now. Likely more. This is mammalian adaptation.
bnonews.com/index.php/2024…
Image
2) I suspect cats are drinking milk from the dairy cows on the dairy farms. This is why we shouldn’t drink raw milk 🥛 currently. Even pasteurized milk, some scientists are unsure of because of lack of safety data. See thread 🧵 below.
3) Not just cats — certain dog breeds (like beagles are highly susceptible to H5N1 avian flu too. And such dogs can facilitate their adaptation towards humans eventually (since more dogs are around people than dairy cows).

pubmed.ncbi.nlm.nih.gov/20580396/
Image
Read 10 tweets
Eric Feigl-Ding Profile picture
Apr 25
📍Let this sink in—a world leading virologist @RickABright who has studied H5N1 bird flu says he is pausing all his milk consumption until he sees proof from both FDA & USDA that pasteurized milk is safe to drink. Pausing milk because of his concern over lack of transparent data.
Why are scientists pausing milk intake? Because there still isn’t enough data on safety of pasteurized milk. There has been data on other viruses in the past that survive pasteurization. See detailed thread 🧵 below.
3) also avoid raw and undercooked eggs for now just to be safe…
Read 15 tweets
Eric Feigl-Ding Profile picture
Apr 24
Testing conducted by the FDA on pasteurized commercially purchased milk has found genetic evidence of the H5N1 bird flu virus. ➡️But the testing, done by PCR cannot distinguish between live virus or fragments of viruses that could have been killed by the pasteurization process.

The FDA said it has been trying to see if it could grow virus from milk found to contain evidence of H5N1, which is the gold standard test to see if there is viable virus in a product. 📌The FDA *does NOT explicitly say FDA laboratories were unable to find live virus in the milk samples, but nevertheless it does state that its belief that commercial, pasteurized milk is safe to consume has not been altered by these findings.

(Sound familiar? Just like blanket assuming a virus “isn’t airborne”, “cannot transmit without symptoms”, “no human to human transmission” errors during COVID). That said, I will am hopeful that no live virus will be found in confirmation. But let’s be precautious.
statnews.com/2024/04/23/h5n…Image
2) PPE and safety googles or face shield recommended for dairy farmers and anyone handling raw milk 🥛. Also they warn about poor fitting respirators for children (who may work near dairy— like I used to help on a dairy farm as a kid in rural Pa). Image
3) people working with cattle 🐄 should also “avoid eating drinking smoking chewing gum in contaminated areas or touching eyes.” And people exposed should wear PPE should be monitored for symptoms for 10 days. Image
Read 10 tweets

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