With infections down more than 90% since highs just 6 weeks ago

It is tempting to decide the pandemic is over

It is not

During this upcoming lull of infections (and falling deaths),

It's time to prepare for whatever is next

So what to prepare for -- and how?

Thread
The two questions I get asked most often these days are:

1. Will we see future variant

Answer: I don't know. No one does. Reasonable to assume we will. Let's hope we don't

2. Will we see future surges

Answer: most likely yes. Hope not

But remember: hope isn't a strategy

2/n
So with possible future variants and surges

We should focus on the playbook:

1. Surveillance
2. Vaccinations
3. Testing
4. Ventilation/filtration
5. Masking
6. Therapeutics

Much of this is in today's White House plan

(disclosure: I, others have shared our ideas with them)
So let's go through these a bit

1. Surveillance means more waste water, more sequencing, etc.

2. Vaccinations:
a. Keep engaging more eligible folks to get vaccinated
b. Work on getting kids <5 vaxxed when data is here
c. Work on new generation of vaccines

4/n
3. Testing:

Critical we ensure rapid tests continue to be widely available and cheap.

Stockpiling tests during lulls (when they are not in hot demand) is key

4. Improving ventilation/filtration of indoor spaces

This is widely doable with a concerted strategy

5/n
5. Masking

Most places have removed mandatory masking and I think that is reasonable during lulls like current one

But high quality masks should still be ubiquitous, accessible, inexpensive

And people who want to wear one should be supported
And finally,

Therapeutics (Paxlovid, remdesivir, monoclonals) critical

Once they become ubiquitous (supplies getting better), it'll make a huge difference

We need to have enough for every high risk (think immunocompromised) person who gets an infection.

We're close

7/n
And last, but certainly not least,

We need to redouble our efforts to get the world vaccinated

Its not just about dosing out there....

Its also about syringes, supply chains, personnel, countering misinformation

Working with partners like COVAX, Africa CDC, etc. is key

8/n
That's largely what you see in the WH plan (COI: I and dozens of other experts spoke to the WH and shared our ideas

Given that it will take some resources,

Congress needs to be involved with support and oversight

9/10

whitehouse.gov/covidplan/
Bottom line is we are now at point where COVID will fade from the headlines. At least for a bit.

This is a good time to prepare for future surges/variants

More therapeutics, vaccines, tests, high quality masks are critical.

So whatever we are faced with -- we are ready

End

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More from @ashishkjha

Feb 26
For two months, I've said we're entering a new phase of the pandemic

A phase marked by a lot of population immunity, a more immune-evasive but less virulent virus

This new phase requires new metrics

My @nytopinion piece on the latest CDC metrics

nytimes.com/2022/02/25/opi…
Fundamentally, new CDC metrics get it right

Why?

Because cases no longer are the most important measure

For nearly 2 years, for every 1000 cases, you could reliably predict 50-80 would end up in the hospital and about 15 to 20 people would die

That was true in 2020. And 2021
That tight link between cases --> hospitalizations --> deaths was true for original strain

And for Alpha
And for Delta

But Omicron severed that link (mostly)

Now, if you told me there were a 1000 new cases

I can no longer tell how many will end up hospitalized or dead

3/n
Read 9 tweets
Feb 18
Nationally as infections return to pre-Omicron surge levels,

Two states I've tracked closely are California & Florida

They're both large with diverse populations, similar seasonality, different COVID approaches

So what can we learn from comparing them?

A few things

Thread
First, let's compare how they did on infections during Omicron surge

Strikingly similar (see graph)

Florida peaked earlier, California a bit later

Cumulatively, they had nearly identical infection rates

About 9.50% of Floridians got infected while 9.54% of Californians did
So at first blush, looks like their different COVID strategies did not end up mattering much

But, when we look at deaths,

A different, surprising pattern emerges

Cumulatively, Florida had 33% more deaths per capita than California during Omi surge

That's a lot

Why?

3/5
Read 6 tweets
Feb 16
As the Omicron surge of infections abates,

Its worth reflecting on few lessons we learned

Today, lets' discuss whether Omicron was indeed "milder"

Short answer? Yes it was

But it still caused a devastating loss of life

And that's a lesson for managing future waves

Thread
First, let's talk about how we might assess whether Omicron was "milder" than Delta

One way is to look at case fatality rate

Remember CFR is proportion of identified cases that end up dying

Throughout the pandemic, the CFR of of COVID in the US has been between 1.5% to 2.0%
CFR is usually 1.5% but rises to 2.0% during surges as hospitals fill

Meaning that as hospitals fill up, admission thresholds rises...and ability to care for sick people diminishes

Its bad to be sick during a COVID surge

So what happened to CFR over the past 2 months?
Read 10 tweets
Feb 10
Let's discuss a path forward for masks in schools

I've been a strong proponent of masking in schools

So as we enter a new phase

Do we need to keep masking for the foreseeable future

I don't think so

Should we ban masks in schools today?

No

Let's find a middle path

Thread
First, let's talk evidence

Do masks work to reduce transmission?

Absolutely

What about in kids?

The evidence is less strong but clearly, the weight of evidence says that masking also works in kids

Are there harms?

Not much evidence either way but there could be

2/n
So given the (imperfect) evidence

Masking in schools was important while two things were true:

There were no vaccines for kids

Large surge of infections in the community

Now, as we enter a new phase

Every school-age kid can be vaccinated

And infections are getting low

3/n
Read 10 tweets
Feb 6
Quick update on the state of the pandemic in the US

Nationally,

Infections are down 60%

Hospitalizations down about 30%

Deaths have largely plateaued at a very high 2500+ per day

Beneath the headlines, we see dropping infections in every part of the country
Here are the four largest states

Geographically, politically diverse with very different strategies and mitigation policies

Infections are down 50-80% across these states

And hospitalizations have turned the corner in each of these states

Deaths are starting to follow
In fact, based on analysis from @CovidActNow

Infections are falling in 47 states. And quickly

And in 3 states, they have plateaued

That's good

So what happens next?

Several things
Read 8 tweets
Feb 1
I've been saying for weeks that as cases recede

We can soon relax public health restrictions

I think of this like the weather

When it is bucketing rain

Umbrella, rain coat, boots, are all essential

When the storm turns into a drizzle, those become less critical

Thread
A big spike (like Omicron surge) is like a major storm

If you don't want to get wet, you need to stay home

But if you venture out

Bring a big umbrella (vaccines)
Wear a raincoat (good masks)
And rainboots (avoid crowded indoor spaces)

You get the idea

2/n
Right now, the storm is starting to ebb

Infections are falling, hospitalizations down

But with infections still high

Indoor mask mandates make sense. As do indoor capacity limits

Many states still have them (though bars are open in every city in America, as far as I know)

3/
Read 9 tweets

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