I have a bad feeling again—China is reinstating measures & has fired the mayors of 2 key cities. Thus far, China has shut down an industrial city, urged residents not to leave Beijing and closed down schools in Shanghai due to increase of #COVID19. 👀 thehill.com/policy/healthc…
2) If mainland China 🇨🇳 follows the way of Hong Kong 🇭🇰 — then China will be royally screwed. And the world’s supply chain might completely melt down for a period. HK deaths are surging so high it is approaching NYC in spring 2020–and HK hasn’t peaked yet.
3) Worse, “Mainland 🇨🇳 has already started to divert flights away from Shanghai & began lockdown this week with closures in some of its largest provinces. Vessels have stopped departing from Shanghai as a port.” —DAMN that is serious. This is Shanghai! 👀 bloomberg.com/news/articles/…
4) Most of the China and HK surges are #BA2. Meanwhile in England… both cases and hospitalizations surging. And #BA2 is now over 50%. Not good.
5) Assume China knows more than it reveals. They’ve built extra surge hospitals recently too. China has also recently approved rapid antigen testing. They had resisted for over 26 months. Something is very different now. reuters.com/world/china/ch…
6) In the first two months of 2022, the megacity, with a population of nearly 25 million, has logged 1,243 confirmed COVID-19 cases arriving from outside the Chinese mainland. The number is also roughly ~80% of Shanghai's total imported cases last year. xinhuanet.com/english/202203…
7) Regarding Shanghai’s shutdown — its a city of 25,000,000 people! (And likely more, not including illegal migrants without “huko” residency permits). One person describes it this way— he no longer had communication with anyone at his Shanghai office as of Friday.
8) Hong Kong was once as strict on #COVID19 as mainland China was. Yet somehow it partly gave up and lost control. Here is how HK now compares to 44 other *high income* counties. If this hits Shanghai & other major Chinese industrial cities… supply chains worldwide will suffer.
9) UPDATE—the 13-million population city of Shenzhen has locked down! With all non-essential enterprises stop operating, or required to work from home. Buses and subways all suspended. Govt services shut down except for epidemic essential staff. Holy shit. ishare.ifeng.com/c/s/v006LBcjcB…
10) ⚠️ Shenzhen health official Lin Hancheng warns Sunday that this #BA2 strain is "highly contagious, spreads quickly and has a high degree of concealment", leading to widespread community transmission if control measures were not strengthened soon. 👀 xw.qq.com/cmsid/20220313…
11) Update—Jilin (city of 1.3 mil pop where China central govt just fired mayor yesterday) is now building a new 6000-bed isolation 🏥 clinic— in less than a week! Remind you of somewhere in Jan 2020?
12) Outbreak is still early in China 🇨🇳, but look at that near-vertical surge. The fact that it’s simultaneously happening in with lockdowns in multiple cities at once shows urgency that we haven’t seen before. And keep in mind Shenzhen & Shanghai are critical industrial cities!
13) China isn’t alone in this mess. South Korea 🇰🇷 is also see an epic surge— now surpassing all time pandemic highs.
14) If HK is a country, its #COVID19 death rate per capita would be 5x higher than the next highest country (which also has near complete #BA2). If Shenzhen is surging because it is the immediate neighbor of HK. If Shenzhen, the industrial core of 🇨🇳, is disrupted, it’ll be hell.
15) For Western European countries who think they are immune from #BA2 after their recent #Omicron wave… well there is some sobering news for you — your govt leaders who claim ‘COVID is over’ are delusional and lying to you. Learn from what’s happening elsewhere #CovidIsNotOver
17) UPDATE— Apple supplier Foxconn shuts all its Shenzhen factories as #COVID19 outbreak in China grows - ft.com/content/d59c76…
18) Hong Kong health experts say they do not expect local #COVID19 infections to decline any time soon, with one warning residents not to let their guard down, as cases could rebound at any time. HK seems to be in trouble for a while—likely Shenzhen too.
19) with scenes like this in China prior to the lockdown, you can see why Shenzhen region is having to resort to lockdowns to keep things from getting out of hand. In China, population density is by far one of the riskiest thing with a contagious virus.
20) UPDATE— Dongguan, with population over 7 million, has also suddenly gone into lockdown. Dongguan is another major industrial city adjacent to Shenzhen and near Hong Kong.
21) As you can see, cases are rising everywhere in China. It’s not just in northeast Jilin or south near Shenzhen. 23 of the 31 mainland provinces reported confirmed, symptomatic cases over the past week. Including asymptomatic cases, there were almost 10,000 new cases.
22) I’m now confident that #BA2 definitely deserves its own distinct Greek letter, separate or Omicron family. BA1 and BA2 are more different than Delta is from original Wuhan 1.0 strain. And the infectiousness and attack rates don’t lie —BA2 is worse by leaps and bounds! 👇
23) Catch up on what is #BA2–This is a good quick video of BA2 to date, which is much more dangerous and which honestly deserves its own Greek letter. C’mon @WHO. #CovidIsNotOver
24) Bottomline: I believe China is now teetering at the edge between barely containing BA2 wave of COVID-19 and completely losing control like it has in Hong Kong—
25) …which we know could spell horrible conditions outcomes and huge economic difficulties and disruption to the most critical manufacturing and export centers of the world. Thus, this bodes extremely poorly for the rest of the global supply chain crisis and economic stability.
26) What happens in China over the coming weeks will affect the world. COVID is not over — with the world acting slowly only further endangering the world. God help us. medriva.com/china-at-a-cov…
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BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain.
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention.
2) RFK Jr told Trump today there’s now 2 measles deaths.
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏
2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)
2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)." nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.
"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts.
2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...
If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here. cdc.gov/fluvaxview/das…
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.