Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
David Sinclair Profile picture
@davidasinclair
Mar 16, 2022 • 5 tweets • 3 min read • Read on X
What do lentils have to do with #Covid_19? Lectins are ancient proteins that evolved before antibodies to inactivate invading organisms. Human mannose-binding lectin has been found to inactivate #SARSCoV2. So have lectins in plants, such as one made by the common lentil 🌱1/n Image
Mannose-binding protein, MBL, is a member of the collectin family, and it has a carbohydrate recognition domain and a collagen-like domain @NatImmunol 2/n nature.com/articles/s4159…
The first study of lectins began 134 years ago by Peter Stillmark who found that the seed extracts of the Castor bean can cause red blood cells stick together. The lectin was named Ricin. 3/n ncbi.nlm.nih.gov/pmc/articles/P…
Plant lectins with antiviral activity were first reported in 1988: D-mannose-specific plant lectins blocked the binding of HIV in-vitro 4/n
Well written science-based article by Bill Haseltine @Forbes 5/n forbes.com/sites/williamh…

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with David Sinclair

David Sinclair Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @davidasinclair

David Sinclair Profile picture
May 12
How healthy are your gums? New study finds a significant genetic overlap between gene variants for gum disease and age acceleration

How might gums affect aging & how do I maintain excellent oral health? 🦷🧵 Image
Periodontitis is a chronic inflammatory disease caused by the accumulation of bacterial biofilms (plaque) on teeth, resulting in inflammation, swelling, bleeding & regression of gums Image
About half of all US adults have periodontitis. Severe periodontitis has a prevalence of approximately 11% globally Image
Read 10 tweets
David Sinclair Profile picture
May 10
NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy

Huh? Is fasting still worth it? ... 🧵 Image
121 humans with obesity who were randomized to standard care (SC), calorie restriction (CR) or intermittent fasting plus time-restricted eating (iTRE), the largest study to measure human autophagy in response to a nutritional intervention Image
Autophagy, which means "self-eating," is the process where cells break down and recycle their own components, like damaged proteins and organelles, to generate energy and building blocks Image
Read 16 tweets
David Sinclair Profile picture
May 9
NEW STUDY: Intermittent fasting improves fertility -not by improving sperm - but by making mice hornier

Does this happen in people?
@Cell_MetabolismImage
In humans, aging is well-known to promote HSDD*, a syndrome characterized by low sexual desire associated with psychological stress

*(Hypoactive sexual desire disorder) Image
Mice underwent every other day (EOD) feeding from 8 weeks of age, which a lot of time without food for a little mouse 🐭🧀 Image
Read 15 tweets
David Sinclair Profile picture
May 8
Longevity is built one good habit at a time. Here are 5 habits to start today: 🧵 Image
1. Eat within a shorter time window (2 to 5 years extra) 🍽️ I try to eat one meal or a late lunch and early dinner. A 4-8 hour time window can activate longevity genes and increase insulin sensitivity Image
2. Buy a standing desk (+2 years)🧍‍♀️Sitting is the new smoking. Weakness in the hips and a lack of balance is a leading cause of death and lower back pain is the leading cause of disability globally. Remember: we are physically not designed to sit for hours Image
Read 8 tweets
David Sinclair Profile picture
May 5
NEW PAPER @biorxivpreprint Brain aging is associated with a "shift toward stress-responsive programs & a progressive loss of cell identity with aging" consistent with The Information Theory of Aging
tinyurl.com/2zc85kbaImage
"Epigenetic aging is also reversible process, as expression of pluripotency factors (OSK(M)), activation of SIRT6, and modulation of other histone modifying enzymes 1have been shown to mitigate certain aging phenotypes." Image
However, prior studies on brain aging largely rely on bulk tissue analyses (no single cells), which obscure cell-intrinsic aging effects and fail to capture regulatory changes across different brain cell types and regions
Read 7 tweets
David Sinclair Profile picture
Apr 23
The polyphenol fisetin found in strawberries clears senescent cells in diabetic mice to prevent aortic aging. Combined with metformin it shows even better effects 🍓🧵 Image
Fisetin (Aladdin, CAS: 528-48-3, Powder Purity: ≥ 95%) was prepared in 60% Phosal 50 PG, 30% PEG400, and 10% ethanol. Fisetin or vehicle was administered in mice by oral gavage Image
The old mice were administered with vehicle or 100 mg/kg/d fisetin for 3 consecutive days once monthly
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(