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David Sinclair Profile picture
@davidasinclair
Mar 16, 2022 • 5 tweets • 3 min read • Read on X
What do lentils have to do with #Covid_19? Lectins are ancient proteins that evolved before antibodies to inactivate invading organisms. Human mannose-binding lectin has been found to inactivate #SARSCoV2. So have lectins in plants, such as one made by the common lentil 🌱1/n Image
Mannose-binding protein, MBL, is a member of the collectin family, and it has a carbohydrate recognition domain and a collagen-like domain @NatImmunol 2/n nature.com/articles/s4159…
The first study of lectins began 134 years ago by Peter Stillmark who found that the seed extracts of the Castor bean can cause red blood cells stick together. The lectin was named Ricin. 3/n ncbi.nlm.nih.gov/pmc/articles/P…
Plant lectins with antiviral activity were first reported in 1988: D-mannose-specific plant lectins blocked the binding of HIV in-vitro 4/n
Well written science-based article by Bill Haseltine @Forbes 5/n forbes.com/sites/williamh…

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More from @davidasinclair

David Sinclair Profile picture
Jan 25
New study finds immune T cells engineered to kill zombie senescent cells 🧟‍♀️ can reverse key aspects of aging in mice 🐁 including metabolic & physical decline. Imagine a single treatment that protects from aging, for life…see thread nature.com/articles/s4358…
Image
CAR T-cell therapy, short for Chimeric Antigen Receptor T-cell therapy, is a type of treatment in which a patient’s immune T cells are changed in the laboratory so they will attack cancer cells or, in this case, senescent cells that cause aging
uPAR is a protein on the cell surface and serum that promotes wound healing and cancer. The Lowe Lab @cshl previously showed upregulation of uPAR on senescent cells & how targeting this protein with CAR T therapy could kill senescent cells in young mice ⬇️ nature.com/articles/s4158…
Read 8 tweets
David Sinclair Profile picture
Dec 15, 2023
“The Information Theory of Aging” was published today. Free copy @NatureAging rdcu.be/dtGSC
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The “ITOA” states that a cause of aging is a loss of epigenetic information that disrupts the ability of cells to read the right genes, causing them to lose their identity and malfunction… Image
This loss can be accelerated by broken DNA (cf. X-rays, CT scans, UV radiation) and other biological threats to cell survival that cause a rearrangement of the epigenome… Image
Read 15 tweets
David Sinclair Profile picture
Dec 13, 2023
400 million people are allergic to dust mites, which feed on skin flakes in beds & carpets. When mice were exposed to mite allergens, the NAD booster NMN reduced airway inflammation & mucus. Trials of NMN against allergies & asthma are warranted 🤧 See thread… Image
Here’s the primary paper:
sciencedirect.com/science/articl…
The main dust mite allergens are proteins found in the feces and body fragments of mites. These microscopic particles can become airborne and, when inhaled, can trigger allergy symptoms… Image
Read 9 tweets
David Sinclair Profile picture
Nov 29, 2023
Our latest paper adds to the scientific discussion on the role of sirtuins in aging. There been some confusion about the implications.
Here’s the scoop:

onlinelibrary.wiley.com/doi/full/10.11…
Image
1. From 1994-2005, the budding-yeast “silent information regulator #2” or “SIR2” gene was shown to extend lifespan & mediate lifespan extension due to hormetic biostressors e.g. heat, low aminos & calorie restriction…



m.genesdev.cshlp.org/content/13/19/…
nature.com/articles/natur…
Image
2. There are 7 SIR2-like genes or “sirtuins” in mammals:
SIRT-ONE to SIRT-SEVEN. Even though the name seems similar, SIRT-TWO is a distant cousin of yeast SIR2… Image
Read 14 tweets
David Sinclair Profile picture
Nov 9, 2023
Isoleucine is an essential amino acid which, in excess, counters the health benefits of the mTOR longevity pathway. The @LammingLab is reporting that an isoleucine-restricted diet extends the lifespan of mice by 33% 👏 @Cell_Metabolism Image
Here a link to the paper…cell.com/cell-metabolis…
In 2022, Dudley and his @LammingLab previously showed Ile restriction promotes metabolic health in mice, that restriction of dietary isoleucine is required for the metabolic benefits of a
low-protein diet, and that higher dietary isoleucine levels are associated with increased BMI in humans!
Image
Read 6 tweets
David Sinclair Profile picture
Oct 9, 2023
New study shows people with increased iron blood markers tend to have older epigenetic ages. Another piece of evidence that high iron levels probably accelerate aging… 1/n tinyurl.com/zhy72aun
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More and more scientists suspect that high iron levels probably cause normal cells to age faster and ultimately become senescent zombie cells 🧟‍♀️. We know for sure that a common feature of senescent cells is their high iron content Image
Unless your doctor says you are iron deficient, it’s worth rethinking the regular use of iron-containing supplements
Read 10 tweets

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