New #Ebolavirus research shows how 2 powerful antibodies can neutralize #Ebola—and Sudan virus bit.ly/3wg9Lkz
“Finding antibodies with this breadth is important because we don’t know which virus in the genus of ebolaviruses is going to break out next."
1/🧵
“Finding antibodies with this breadth is important because we don’t know which virus in the genus of ebolaviruses is going to break out next."
1/🧵
To save lives, doctors need broad-spectrum therapies that neutralize as many Ebolavirus species as possible.
This @CellPressNews study shows 2 potent antibodies that can neutralize the well-known Ebola virus and Sudan virus (also responsible for large, deadly outbreaks.
This @CellPressNews study shows 2 potent antibodies that can neutralize the well-known Ebola virus and Sudan virus (also responsible for large, deadly outbreaks.
The team used #CryoEM to get a clear view of these two antibodies in complex with the #Ebolavirus glycoprotein.
1 antibody, called 1C11, neutralizes the virus by binding with a site on the fusion machinery the virus would normally use to enter and infect host cells.
1 antibody, called 1C11, neutralizes the virus by binding with a site on the fusion machinery the virus would normally use to enter and infect host cells.
The second antibody, called 1C3 is a bit of a show off. This antibody lodges itself in a way that binds ALL THREE monomers in the glycoprotein trimer at once.
“This antibody might punch above its weight,” says study co-leader @EOSaphire.
“This antibody might punch above its weight,” says study co-leader @EOSaphire.
👉Another finding—and this is CRITICAL—these antibodies do not waste their energy targeting soluble glycoprotein.
They aren't going to fall for the virus's decoy!
This means a future therapy that combines these antibodies might be effective at a low dose.
They aren't going to fall for the virus's decoy!
This means a future therapy that combines these antibodies might be effective at a low dose.
To test this idea, the researchers worked with non-human primates.
They found that even the lowest dose of this 2-antibody cocktail could protect against Ebola virus and Sudan virus disease, reversing severe symptoms.
They found that even the lowest dose of this 2-antibody cocktail could protect against Ebola virus and Sudan virus disease, reversing severe symptoms.
The new study was led by LJI's Dr. @EOSaphire, @EmoryUniversity Dr. Rafi Ahmed and @NIAIDNews's Dr. Gabriella Worwa.
Read the full study in @CellPressNews: doi.org/10.1016/j.cell…
#Ebolavirus #immunology #antibodies
Read the full study in @CellPressNews: doi.org/10.1016/j.cell…
#Ebolavirus #immunology #antibodies
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