Discover and read the best of Twitter Threads about #antibodies

Most recents (18)

We know about T-cells. A new study detects cross-reactive #coronavirus antibodies.

“We have detected a high seroprevalence of seasonal hCoVs in up to 75% of individuals both unexposed to SARS-CoV-2 and recovered from #COVID19

Pre-existing immunity? 🤔

medrxiv.org/content/10.110…
T-cells and cross-reactive antibodies... 🤔

“We show that infection with SARS-CoV-2 mounts cross reactive antibodies against hCoV-OC43 antigens. The reverse direction of preexisting antibody responses targeting seasonal hCoVs recognizing SARS-CoV-2 is more difficult to assess.”
What this means is that people who had COVID have antibodies against coronavirus-based common colds. If the reverse is true then people who had coronavirus-based colds have antibodies against COVID. We know that ~60% of people who never had COVID have T-cells against COVID...
Read 5 tweets
We reviewed the first analysis of mortality among patients receiving #ConvalescentPlasma therapy from #COVID19 survivors through the US Expanded Access Program. The effect of #ConvalescentPlasma on #COVID19 mortality has not previously been well described bit.ly/3gpFGDn
In full disclosure, the lead author is based at Hopkins; however, none of the NCRC reviewers were direct collaborators. Thus, the article had an independent external review by someone without current or past professional collaborations with the author and no Hopkins affiliation.
In this preprint on @medrxivpreprint, Joyner et al analyzed 35,322 hospitalized #COVID19 patients from 1,809 sites overseen by @MayoClinic, from April 4-July 4. They assessed if timing of #ConvalescentPlasma reduced #mortality and if higher doses of #antibodies reduced mortality.
Read 9 tweets
🚨#THREAD🚨
200 Best Thriller Films (World Cinema)
#OldBoy (2013) #Triangle (2009) #Psycho (1960) #Seven (1995) #TheSilenceoftheLambs (1991) #Identity (2001)
#TheWailing (2016) #Inception (2010) #Interstellar (2014) #FightClub (1999) #TaxiDriver (1976) #Kalifornia (1993)
#ShutterIsland (2010) #Perfume: The Story of a Murderer (2006) #Memento (2000) #Hannibal (2001)
#Insomnia (2002) #TheDeparted (2006) #SleepTight (2011) #Marshland (2014) #TheHiddenFace (2011)
#Julia's Eyes (2010) #TheSkinILiveIn (2011)
#Kidnapped (2010) #Jacob's Ladder (1990)
#Memento (2000) #Forgotten (2017) #Dunkirk (2017)
#Following (1998) #EternalSunshineoftheSpotlessMind (2004) #TheFountain (2006) #DarkCity (1998) #Primer (2004) #Orphan (2009) #PhoneBooth (2002) #Split (2016) #TheSixthSense (1999) #RunLolaRun (1998)
#ConfessionofMurder (2012)
Read 16 tweets
1/ The next hot-button issue in #COVID19 debates: the relative importance of #antibodies versus T cells in #COVID_19 immune response.

(If you're thinking this should be an obscure, wonky, data-driven debate, I have one word for you: hydroxychloroquine.)
2/ Some background. Antibodies are not the only possible source of #COVID19 immunity.

Or as this interesting @NatGeo article puts it, "antibodies might not be telling the whole story when it comes to #Covid_19 immunity."

on.natgeo.com/2DpoH6V #COVID
3/ Dr. Soo Aleman of Sweden tested patients who previously tested positive for #COVID19, as well as their close contacts. She found that hospitalized patients had strong antibody and T cell responses to #COVID_19 -- no surprise there.

#COVID #coronavirus
Read 18 tweets
ALL YOU NEED TO KNOW ABOUT RHESUS INCOMPATIBILITY

If the #RhesusStatus of your partner or spouse is not compatible with yours & you do nothing about it, it can lead to repeated miscarriages, jaundice in your baby, & stillbirths.

A thread 🧵

{Share to create awareness!}
Every person's blood group can either be A, B, AB or O.

Similarly, we are all classified as Rhesus Positive (Rh+) or Rhesus Negative (Rh-). This depends on whether you have a protein called #RhesusAntigen on the surface of our red blood cells or not.
If you have rhesus antigens on your red blood cells, you are RHESUS POSITIVE.

If you don't have rhesus antigens on your red blood cells, you are RHESUS NEGATIVE.
Read 21 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
I recommend reading about immunological synapses to better understand how various immune cells (particularly T cells and NK cells) can grab onto antigens and aid B cells in maturing higher affinity BCRs and antibodies, as well as encourage division

en.m.wikipedia.org/wiki/Immunolog…
CD8+ “Killer” T cells: jcs.biologists.org/content/129/15…
B cells and CD4+ Th cell mediated antibody formation and B cell activation:

step1.medbullets.com/immunology/105…
Read 17 tweets
Let’s do a quick one on #clinicaldecisionmaking and #neuroimaging. See bright spot on MRI T2 Brain just means increased water -could be any insult to the brain - #infection #inflammation #ischemia #neoplasm are the top 4 you gotta have in your brain. Pun intended. #MedTwitter
Then you think - active or inactive process? If it’s actively destroying the BBB, it’ll enhance on contrast enhancement. So get MRI with and without contrast. Why without? T2 shine-through - but that’s for another time. #MedStudentTwitter #neurology #neurologyresident
Now the important question here is what you do - remember that nice poem on #theroadnottaken by #robertfrost? 2 widely diverging choices - to immunosuppress or not to immunosuppress. #tobeornottobe #hamlet #MedTwitter #AcademicTwitter #MedStudentChat
Read 13 tweets
Daily Bookmarks to GAVNet 5/23/2020-2

greeneracresvaluenetwork.wordpress.com/2020/05/23/dai…

Sooner or later we all face death. Will a sense of meaning help us? | Aeon Ideas

aeon.co/ideas/sooner-o…
#Death #meaning
How to Trade Oil With Negative Prices: Interactive Brokers - Bloomberg

bloomberg.com/news/articles/…
#Oilprices #trade #negative #price
Science in the Age of Computer Simulation, Winsberg

press.uchicago.edu/ucp/books/book…
#Computers #Science #Simulation
Read 6 tweets
#SARSCoV2 There are several kinds of #vaccines, whereby all share the goal of generating adaptive #immunity via 1) #antibodies via B cells, and 2) T-cell receptors (#TCRs) via T cells:
1) live-attenuated, where you produce an actual #virus in an egg or cell line
2) #recombinant, where you introduce #DNA into yeast, bacteria, or cell lines — you produce pieces of the #virus #proteins, then either administer them as-is or typically by linking them to immunogenic substrates like albumin, BSA and KLH
Read 6 tweets
ICYMI back on Feb. 7, 2020, I published: "A Harvester of Sorrow – First Wave of the SARS 2.0 Novel Coronavirus" / #COVID19 #1918Pandemic #Pandemic #Coronavirus #SARS traderstef.wordpress.com/2020/02/12/a-h… Image
San Francisco had the 1918 flu under control. And then it lifted the restrictions #COVID19 #1918Pandemic #Pandemic #Coronavirus #SARS nbcnews.com/politics/polit…
#COVID19 #1918Pandemic #Pandemic #Coronavirus #2ndWave no kidding, use summer as a time to prep just in case, no matter what anyone says, bc a virus is much smarter than any of you...
Read 318 tweets
Some have suggested that detection of #SARSCoV2 antibodies could be a basis for an “immunity passport” / “risk-free certificate” that will enable individuals to return to work. Currently, there is no evidence those who have recovered from #COVID19 are protected from re-infection.
Immunity to a pathogen through natural infection is a multi-step process that usually takes place over 1-2 weeks. The body responds to a viral infection immediately with a non-specific innate response: macrophages, neutrophils, dendritic cells slow the progress of the virus.
This non-specific response is followed by an adaptive response i.e. body makes #antibodies that specifically bind to the #virus. These #antibodies are proteins called #immunoglobulins. The body also makes T-cells that recognize & eliminate other cells infected with the virus.
Read 8 tweets
🚨BREAKING: 2.5-4.2% of 3,300 people in Santa Clara County #CA tested positive for #coronavirus antibodies.

Researchers believe that 48,000-81,000 residents had #COVID19, **50- to 80-fold more** than the ~1,000 in the official tally.

@Almondrobopanda
abcnews.go.com/Health/antibod…
🔥“Our findings suggest that there is somewhere between **50- and 80-fold more (#coronavirus) infections** in our county than what’s known by the number of cases...reported by our department of public health," Dr. Eran Bendavid (@StanfordMed).

#WhereAreTheTests #COVID19
Dr. John Brownstein (@Harvard epidemiologist) says this confirms "what we've expected...a MUCH LARGER number of cases than we ever anticipated."

"There has been wide recognition that we were undercounting infections because of *lack of testing* or patients were asymptomatic."💥
Read 6 tweets
⚠️@FEMA & @CDCgov’s draft strategy to reopen says even a cautious/phased approach entails a “significant risk of resurgence” of #coronavirus & warns of a “large rebound curve” of #COVID19 if mitigation is relaxed before vaccines or herd immunity occur.

washingtonpost.com/news/powerpost…
Before easing #StayHome, we need the following:

▶️“genuinely low” #COVID19 cases
▶️broad #coronavirus TESTING: “well functioning” monitoring “promptly detecting” outbreaks
▶️aggressive contact tracing
▶️enough hospital beds to rapidly scale up
▶️ramped-up production of #PPE
Reopening too early RISKS LIVES, but @realDonaldTrump claims “the plans to reopen the country are close to being finalized.”

Yet Trump hasn’t committed to following these or other recommendations from the experts, as the WH drafts its own plans.🤬

#coronavirus #COVID19
Read 7 tweets
🚨 #Coronavirus Thread Part 3 🚨

Dr. Anthony Fauci announced that "antibody test is coming in a week or so". What does #antibody mean?

#Antibodies are proteins in the immune system that are developed after someone gets infected. It is the antibodies that make someone.../1
...immune against getting reinfected. In other words, what doesn't kill you makes you stronger.

It means two things;
1. You were previously infected.
2. You are likely to be protected against the #coronavirus at least for a while. Again, this is a paradox - a herd immunity.../2
sounds lovely and may dampen the 2nd wave of infection in the population but if the virus mutates (change in genetics), then it means a RESET and the entire population is once again at the mercy of the virus.

Why is antibody testing so vital? Why are governments.../3
Read 11 tweets
We need some #GoodNews. Yes, this is a study in mice but this is so far the first peer-reviewed #coronavirus #vaccine study with promising results in @EBioMedicine published by @TheLancet from @PittTweet @UPMCnews @PittHealthSci vaccinologists
When tested in mice, the #vaccine, delivered through a fingertip-sized patch, produces #antibodies specific to #SARSCoV2 #virus. Researchers were able to act quickly because they already laid the groundwork during earlier #coronavirus #epidemics.
Compared to the experimental #mRNA #vaccine that entered clinical trials, this one - called #PittCoVacc, short for #Pittsburgh #Coronavirus Vaccine - follows a more established approach, using lab-made pieces of viral protein to build immunity (same way current #flu shots work)
Read 8 tweets
1 - right, this is my 1st attempt at a long thread. I feel I’ve discovered something interesting & a penny has dropped! Some things #DeepState are doing doesn’t make sense on its own but when you put them together, it begins to fit. Happy reading!
2 - okay, here’s a thought... what’s #foodsafety ‘use by’ dates got to do with #chemtrails #GeoEngineering? Chemtrails would fall on everyone including the evil. I believe they only react with certain other chemicals; those in drugs popular with us non-elite...
3 - #ibuprofen (ans to physical pain) & depression drugs (and to psychological pain). Most of us covered! The aim of chemtrails it to react & weaken our #immune system while #vaccines reduce our #fertility as well as weaken us. @BillGates even admitted in a @bbc interview...
Read 10 tweets

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