Discover and read the best of Twitter Threads about #antibodies

Most recents (24)

Antibody landscapes after influenza virus infection or vaccination by Ron Foucier…
Much of the global burden of infectious disease today is caused by antigenically variable pathogens, which escape immunity induced by prior infection or vaccination by changing the molecular structure recognized by #antibodies
Human influenza viruses are notorious for their capacity to evolve and evade the adaptive immune response.
Read 10 tweets
Antibody Affinity Maturation to SARS-CoV-2 #Omicron Variants in a #Teachers Cohort…
Our study, released on @medrxivpreprint this week, looked at the #Covid immunity response of a cohort of primary school staff: 61% had been infected in the 6 months prior to their @Attomarker test and were probably exposed to BA1 or BA.4/5.
The good news is that a number of teachers developed high-quality #antibodies, both in concentration and quality and tuned to the local variant. We think this may have been because they had been repeatedly exposed to SARS-CoV-2.
Read 10 tweets
With passage of the National Alzheimer’s Project Act (NAPA) in January 2011 and the subsequent “National Plan to Address Alzheimer’s Disease”, the war on Alzheimer’s has only just begun. But one key aspect is glaringly absent: specific funding commitments…
More than 5 million Americans now suffer from Alzheimer, and that number is expected to more than double by 2050. Between 1998-2011, there were 101 unsuccessful AD drugs in development and only three approvals (none since 2003)
@AndrewWLo Kenneth @KosikLab…
"If a single drug-development program takes 13 years
from beginning to end and has a 5% probability of success, the expected waiting time for the next approved Alzheimer's disease drug is 260 years"
-@AndrewWLo, Carole Ho, Jayna Cummings, @kennethskosik
Read 18 tweets
The lies 2020:

Don’t Panic, we go for #herdimmunity, #children can’t spread it and won’t be harmed

What was really
And use #schools as a tap for controlled spread. No transparency, no testing no mask

Lets spread the lie that mask simply don’t work

Here #polarisation starts driven by misinformation and intransparancy by your government. Everybody could see that the measures were nog in line with urgency.

What were they hiding? Why no #zerorisk #zerocovid with borders closed. It could be done

2020: wait we know this will
Lead to many many deaths but the #vaccin is almost here, working hard, we know the #SPIKE is a big thing, hold on #Hopium being built.

Meanwhile lets keep up the lie of children not important to monitor😢 we know from SARS they build less #antibodies lets presume they just not
Read 31 tweets
Gestern kam ein interessantes Interview mit Deutschlands berühmtesten Maßnahmenkritiker, der auch das Schweden-Modell favorisierte. 1/7

Mir dämmerte es erstmals was die sog. Pandemie betrifft als ich 2020 die RKI Kurve sah (erste Welle). Aus dem Ro Wert (Basisreproduktionsrate) lässt sich die Herdenimmunität berechnen, wobei Ro angibt, wie viele Menschen ein Infizierter im Schnitt ohne Maßnahmen ansteckt.
Herdenimmunität = 1 - 1/Ro

Die Formel gibt an, wie viele Menschen gegen das Virus immun sein müssen, damit eine Herdenimmunität eintritt u. sich der Erreger nicht mehr (exponentiell) weiterverbreiten kann (genau genommen ist es die Gompertz-Fkt.)…
Read 7 tweets
Zum #Infektionsschutzgesetz (-Entwurf): Nach "Geimpften" und
"Geboosterten" kommen jetzt "frisch Geimpfte" (3 Monate) und ab Okt. wieder Masken.
#Masken(Mandate), sog. #Impfungen u. #Lockdowns wirken, aber evtl. nicht gut genug? 1/9
Why do mask mandates fail?

Haben Masken #Nebenwirkungen?…
"Bacterial and fungal
isolation from face masks
under the #COVID‑19 pandemic"…
Umwelt(schutz)aspekte: ZDF: "Jede Minute machen wir drei Millionen Masken zu Müll."…
Read 11 tweets
Nach "Geimpften" und "Geboosterten" kommen jetzt "frisch Geimpfte" (3 Monate) und ab Okt. wieder Masken.
#Masken(Mandate), sog. #Impfungen u. #Lockdowns wirken, aber evtl. nicht gut genug? 1/9
Siehe @johndefeo (Why do mask mandates fail?)

Haben Masken #Nebenwirkungen?…
"Bacterial and fungal
isolation from face masks
under the #COVID‑19 pandemic"…
Umwelt(schutz)aspekte: ZDF: "Jede Minute machen wir drei Millionen Masken zu Müll."…
Read 9 tweets
Exciting work from @KathyYWei1, @AmeyaHarmalkar & @proteinrosh on predicting scFv developability. TLDR: transformers and CNNs can potentially help prioritise mutations sites for enhancing stability (1/5) #antibodies #machinelearning #proteineng
Context: a single-chain Fv (scFv) is an antibody construct whose heavy and light chains are linked. It's not the conventional "Y" shape molecule, and is useful for engineering / phage display, etc. See @AlissaHummer's post… (2/5)
Thermostability (measured by TS50, the temperature when scFv loses binding) is weakly predicted by 0-shot and fine-tuning via transformers (ESM-1v + ESM-1b). CNNs using sequence and structural (energy) convolutions perform better (?) [hard to tell, sorry!🙈] (3/5)
Read 5 tweets
A "negative" result, but phenomenal thought piece from @naturalantibody / @antibodymap. TLDR predicting antibody-antigen interactions is pretty darn hard (1/5) #antibodies #machinelearning #alphafold…
Predicting Ab-Ag interactions is a sub-problem of the protein-protein interaction problem. There are many facets to consider here, including but not limited to, identifying the correct antigen (let alone the correct epitope), the correct paratope, orientation, etc (2/5)
@antibodymap's team show first that true Ab-Ag pairs (i.e. those where we know the Ab binds antigen) and false Ab-Ag pairs (i.e. Ag was randomly given to an Ab), the pIDDT scores are incomparable, suggesting score-based discrimination is HARD. (3/5)
Read 6 tweets
Really excited to announce that AntiBERTa is now published in @Patterns_CP! Here we describe a transformer model that demonstrates understanding of antibody sequences 🧵 (1/6)

#machinelearning #antibodies #drugdiscovery…
We pre-train a transformer model based on RoBERTa. We exclusively use full-length antibody/B-cell receptor sequences using the MLM objective. Other similar transformers FYI include BioPhi (@prihodad), ABLang (@HegelundOlsen), AntiBERTy (@jeffruffolo) (2/6)
We show that the embeddings pick up nuanced features of BCR/antibody sequences. For example, V gene usage mutational load, and remarkably, B cell provenance. This is all done in a zero-shot setting, i.e. none of these labels were provided during pre-training. (3/6) Image
Read 7 tweets
New #Ebolavirus research shows how 2 powerful antibodies can neutralize #Ebola—and Sudan virus

“Finding antibodies with this breadth is important because we don’t know which virus in the genus of ebolaviruses is going to break out next."

To save lives, doctors need broad-spectrum therapies that neutralize as many Ebolavirus species as possible.

This @CellPressNews study shows 2 potent antibodies that can neutralize the well-known Ebola virus and Sudan virus (also responsible for large, deadly outbreaks. Graphical abstract showing ...
The team used #CryoEM to get a clear view of these two antibodies in complex with the #Ebolavirus glycoprotein.

1 antibody, called 1C11, neutralizes the virus by binding with a site on the fusion machinery the virus would normally use to enter and infect host cells. Image
Read 7 tweets
For those wondering how the newest kid on the block, LY-CoV1404 (bebtelovimab) neutralizes variants so well, including #SARSCoV2 #Omicron BA.1.1 and BA.2? The answer is – pure luck! This antibody is like Neo dodging bullets in the matrix…🍀🍀🍀
The binding mode is very similar to imdevimab (REGN10987) but bebtelovimab avoids major imdevimab resistance caused by the N440K Omicron mutation! It also avoids other mutations. Think social distancing of antibodies from mutations...
Can use this 📺 to scroll through and see #Omicron BA.1.1 #SARSCoV2 mutations and where #antibodies bind... Sotrovimab/S309, Casirivimab/REGN10933, Imdevimab/REGN10987, Evusheld (AZD8895/tixa, AZD1061/cilga), Bam (LY-CoV555), Ete (LY-CoV016), and bebtelovimab (LY-CoV1404)
Read 4 tweets
Daily Bookmarks to GAVNet 12/15/2021…
Well-Structured German Study Shows No Deaths among Healthy German Kids Ages 5 to 11 ⋆ Brownstone Institute…

#MedicalStudy, #germany, #COVID19, #mortality, #children, #SchoolClosures
Fast superhighway through the Solar System discovered - Big Think…

#ArchesOfChaos, #SpaceTravel, #SolarSystem, ScientificDiscovery
Read 20 tweets
Neutralization data for #omicron is out. By request of @andrew_croxford, I try to explain how scientists investigate #neutralization. First, it's lab-based data. It’s impossible to directly conclude from neutralization data that #vaccines will not work anymore in the field. 1/X
@andrew_croxford Second, assays are legion! I developed one myself, which is different to the one used by the lab of e.g., @CiesekSandra, in terms of #virus, incubation times, etc. Keep that in mind if you compare two papers directly. I will explain how I did my assay. 2/X
@andrew_croxford @CiesekSandra Third, you must understand that such an assay generates data about neutralization of the virus by antibodies in the serum. These assays do not allow for measuring the effect of e.g., T cells or memory B cells.
@sailorrooscout talks about that here: 3/X
Read 25 tweets
Many thanks to the awesome ladies at @IWS_Network for the chance to share my #immigrant #womanofcolour #womaninscience👩🏽‍🔬story throughout this week as part of their Voices Without Frontiers program!…
#IWSvoices #WomenInSTEM
I was born in #Guyana 🇬🇾
➡️ Amerindian name meaning “Land of Many Waters”.
➡️small in size (<800, 000 people), rich in natural resources
➡️only English-speaking country in South America
➡️Diversity of people with amazing cultural mix @IWS_Network #VoicesIWS #WomenInSTEM ImageKaieteur Falls - world's la...Photo Source: Guyana Times
Genetically I’m Indian - ancestors brought to ‘British Guiana’ from India during colonial times to work on #sugarplantations.

Culturally I’m #Caribbean as #Guyana shares historical and cultural ties with other Anglo-Caribbean countries.

@IWS_Network #VoicesIWS #WomenInSTEM East Woman in the Anglo-Car...
Read 20 tweets
Daily Bookmarks to GAVNet 09/02/2021…
CEO Ridiculed for Raising Minimum Wage to $70K Has the Last Laugh…

#IncomeDisparity #MinimumWage #FinancialPerformance
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination…

#SARSCoV2 #ImmuneResponses #infections #vaccinations #antibodies
Read 8 tweets
As a society we need to
listen to #antivaxxers more
and attack them less.
They are scared.
We don’t know why
until we listen to them.
They want to talk about their fears in the form of statements. People think w words, and often need to process ideas verbally
to sort them.
I just met a very awesome man who has an immune compromised wife.
He is scared of the vaccines.
He kept talking about Malone (quack) and the tech being too new (its not) and all the fear Fear FEAR thats been surrounding the #pandemic and #vaccine rollouts. He is scared.
We DO gain antibodies after natural infection, but they wane. And there aren’t as many of them w natural vs acquired. It takes our bodies a full week to gather troops and launch an attack.
Thats a week of gained if you already have waiting #antibodies.
So how do we communicate?
Read 5 tweets
#CoronaSymptoms can be medicated maybe completely 😃😃😃
"Not only would it explain why steroids work in this disease, but it would suggest that we should be treating the disease more like other autoimmune diseases of the lung."
Read 6 tweets

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