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Dr Elisa Perego Profile picture
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Apr 1 • 10 tweets • 5 min read
Congratulations to @LongCovidKids
and allies for being at Downing Street today and raise awareness of #LongCovid in children and young people 🔥
Proud and committed as usual to support recognition of, and research, into #LongCovidKids

express.co.uk/news/science/1…
There are an estimated ~119.000 children and young people to have experienced #LongCovid in the UK alone. Around 21.000 have been ill for over 1 year. The real numbers could be even higher: some children might be living with subclinical ("silent") pathology or undiagnosed disease
We don't even know about the longest-term effects of SARS-CoV-2 infection in the years/decades to come. Data from other viral infections are sobering: we know viruses are associated, or suspected to be associated, with a wide range of conditions emerging much later from infection
Most recently, infection with the Epstein Barr virus has been connected to the onset of multiple sclerosis much later after the early, acute infection with EBV.

EBV is the pathogen linked to infectious mononucleosis and has been linked to ME/CFS too.

hsph.harvard.edu/news/press-rel…
Some viral infections have also been linked to cancer. While we all hope this won't be the case of SARS-CoV-2, we have, sadly, in my opinion to consider this possibility, too, and apply the precautionary principle.
Children deserve 100% protection.

amp.cancer.org/cancer/cancer-…
Infection with the poliovirus | the virus causing the well-known infectious disease polio | has been linked to the development of post-polio syndrome. Post-polio syndrome is a condition that may emerge decades after infection with the poliovirus

nhs.uk/conditions/pos…
The severe, sometimes devastating ME/CFS has been linked to many viral triggers, too. These include, just to give some examples, the Epstein Barr virus (mentioned above) or enteroviruses (EVs)

frontiersin.org/articles/10.33…
SARS CoV, the SARS virus, is also linked to a plethora of long-term effects. Some people affected by SARS have never fully recovered | see for example my thread 🧵 #longSARS

SARS-CoV-2 | the virus which causes Covid | has many similarities with SARS-CoV

The survivors of Ebola virus disease (commonly known as Ebola) often suffer from prolonged symptoms and sequelae, like ocular and musculoskeletal issues. This is called post Ebola syndrome

Viral persistence and latency are also known for this virus

ncbi.nlm.nih.gov/pmc/articles/P…
And just out a new paper on the link between Epstein Barr and the development of multiple sclerosis

EBV could be a driver and not just an initial trigger for multiple sclerosis

We're just starting to grasp the longest-term effects of many viruses 🔺️

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More from @elisaperego78

Dr Elisa Perego Profile picture
Apr 2
Great thread about the current wave. People are less likely to go into respiratory failure --either because of vaccination | prior immunity or omicron intrinsic features -- or both
But covid is not a respiratory disease only. It's multi-system, with huge cardiovascular potential
Covid can affect all organs and body systems. It can present with prolonged symptoms and sequelae #LongCovid
This is not uncommon. It can be potentially with lifelong consequences. Even in the vaccinated and in those with mild or asymptomatic disease at onset
We obviously all hope vaccination will hold strong. The reduction in mortality and severe disease is important. But significant long-term effects and symptomatic disease are well documented in post-vaccination infections, too
We need to cut transmission. Period.
Read 4 tweets
Dr Elisa Perego Profile picture
Apr 2
Ah this is an excellent point by @ErinSandersNP | clinical trials
We've been on an unrelanted SARS-CoV-2 spread for 2 years: a new, dangerous, highly contagious pathogen. Almost all world risk infection
We won't have "clean" dataset even for studying other diseases anymore

🧵
Biomedical research risks taking a huge hit from unleashed SARS-CoV-2 spread. "Historical" (i.e. pre pandemic) datasets will be useful to an extent. But as the time goes by, and new research is needed, SARS-CoV-2 infection | #LongCovid etc. risk to be huge confounding factors
I simplify a lot. Just a little example. Let's say you want to study autoimmune diseases like reumathoid arthritis or lupus (SLE). We know covid | SARS-CoV-2 infection have been linked to autoimmune phenomena. Many covid patients don't even have proven evidence of infection
Read 8 tweets
Dr Elisa Perego Profile picture
Apr 1
It is critical to recognize covid | SARS-CoV-2 infection | #LongCovid do affect children and young people. We have known this since 2020. Advocacy and patient-led research has been crucial to the recognition of #LongCovidKids since the early pandemic days 💙
We have now a wealth of fresh, growing scientific evidence on #LongCovidKids. This is also from patient-led research and expertise.
It is critical policy makers and medical professionals are fully updated on, and open to address SARS-CoV-2 infection's sequelae
Wonderful to see @LongCovidKids new support guide freely available to families, patients, policy makers and medical professionals 🔥
Testimonials from young people with #LongCovid have been truly instrumental to shed a light on the disease. My gratitude

#LongCovidKids
Read 4 tweets
Dr Elisa Perego Profile picture
Mar 31
Covid | diabetes | #LongCovid

An easy-to-read, short report in top @Nature about Yan Xie and @zalaly recent @TheLancetEndo study.

The study found an increase in diabetes and antihyperglicaemic use within around 1 year post-covid, in survivors.
"Post-acute COVID-19 care should involve identification and management of diabetes"

#LongCovid

thelancet.com/journals/landi…
The @TheLancetEndo study makes use of a 181.280 people-strong cohort of covid patients. It compares their data with a massive pre-pandemic control group (no covid possible!) and a very large control group of contemporary people never diagnosed with covid
Read 4 tweets
Dr Elisa Perego Profile picture
Mar 31
Per gli amici e i pazienti italiani, da domani @LongCovidKids offre un'aggiornata guida scaricabile sul Long Covid pediatrico, pensata per essere accessibile anche alle famiglie e ai giovani malati.

#LongCovid #LongCovidKids
Troverete testimonianze di vita dei giovani pazienti, potenziali meccanismi del #LongCovid pediatrico, patologie connesse, come sindromi post-virali note, e informazioni su prospettive di cura, ricerca, management dei sintomi, e supporto
Troverete la storia di #LongCovid e #LongCovidKids come patologie alla cui identificazione e definizione, i pazienti stessi, con un enorme lavoro di documentazione e advocacy, hanno dato un contributo decisivo a partire dal 2020 Riconoscimento da OMS nello stesso anno
Read 6 tweets
Dr Elisa Perego Profile picture
Mar 31
I disagree with this message by Biden, and similar, by policy makers across the world
It's true that covid is less devastating now, on a population level, where the vaccine is available. But it remains a huge threat, and a big driver of social disruption, death, and disease
Elite people and those in position of privilege have access to tools that may drastically reduce their chance of infection, death and #LongCovid: frequent testing, contact tracing, top healthcare.
Even among them, we are hearing of sudden deaths, health events, prolonged disease
Those in marginalised or less privileged communities are paying, and will be paying, the highest price for an unmitigated SARS-CoV-2 spread: higher rates of infection, ongoing exposure, more covid complications, #LongCovid, poor access to healthcare, and looming poverty
Read 6 tweets

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