Ok it's important to take note of the long-term effects of influenza | #longflu. Influenza can be severe. Flu-related complications can kill hundreds of thousands a year globally
Yet, we've clear evidence covid is *massively* more dangerous and severe than influenza
Go figure 🧵
My tweet is inspired by the spin covid minimizers are trying, to induce people to accept mass infection and herd immunity with a SARS virus.
First, most people associate the "flu" with the relatively common and, often, fast-resolving effects of para-influenza or cold viruses.
Not so many, especially the young, experience severe influenza-related complications, like pneumonia. Seasonal flu often manifests with self-limiting symptoms or is asymptomatic. Sure, some have severe flu, long-term impact #longflu, or may die | Yet, this DIDN'T bring us Bergamo
Comparing influenza and covid "can be difficult" only if you are not open about reality. Or you didn't note we are in a huge pandemic. Or you didn't see the covid mortality data. Or you missed Bergamo. Or you didn't read the *huge* number of publications now available on covid.
Reducing the burden of influenza and other infections must be a priority in public health. This is especially now that #LongCovid has contributed to bringing viral-onset diseases into the spotlight. We can't accept long-term morbidity | e.g. ME/CFS, lung damage | lightly anymore
We must not accept, at the same time, erroneous comparisons between diseases, like covid and seasonal influenza. This wrong comparison is one reason why we're pushed into the pandemic disaster. SARS-CoV-2 is a SARS virus, not an influenza one. Covid is a hugely dangerous disease
Of course, we have now the covid vaccine. The vaccine is cutting mortality, and, hopefully, morbidity from SARS-CoV-2. Yet, covid remains a severe threat, especially in view of fast-mutating variants, #LongCovid, how easy to spread the pathogen is, and its ability to reinfect
Covid remains, even now with vaccination, much more dangerous than seasonal influenza on a population level. It is also as such, on average, on an individual level. Of course, there might be people who go through covid with little effects, but are more susceptible to influenza.
One first key paper on covid lung in the pandemic | Ackermann et al 2020 in top @NEJM | autopsies from severe covid and influenza patients | it was evident covid has a massive potential for thrombotic and vascular damage, much higher and specific vs flu

nejm.org/doi/10.1056/ne…
Many other scientific papers have compared the effects of SARS-CoV-2 infection on human health and physiology vs. seasonal influenza and common upper respiratory viruses. Covid is proven to be more dangerous on multiple levels. We don't have to accept living with this disease
And, as usual, vaccination doesn't necessarily prevent symptomatic, even severe or fatal disease, especially now with omicron. It's a strong weapon, but covid is not "defanged" = rendered harmless as some pieces in the Guardian have rather unfortunately alleged

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More from @elisaperego78

Apr 4
There is now both published evidence and lived experience: covid can kill down the road.
#LongCovid has been linked to severe, even fatal events, like pulmonary embolism, strokes, or infarctions. This can happen even with subclinical ("silent") pathology, or mild symptoms
The cardiovascular potential and multi-system nature of covid | #LongCovid | SARS-CoV-2 infection are huge.
Policy makers need to be crystal clear about this.
Many long haulers from 2020 or 2021 remain with no care. Even vaccinated people are susceptible to symptomatic disease.
Here one of the most recent papers on the long-term term cardiovascular outcomes of cobid within one year

Out in top @NatureMedicine

Even "mild" or young patients are at increased risk of cardiovascular disease and severe events

#LongCovid

nature.com/articles/s4159…
Read 4 tweets
Apr 4
The first reported biopsy of a "covid toe" in #LongCovid || "covid toes" are lesions known to appear on toes weeks or months after SARS-CoV-2 exposure || the biopsy showed evidence of micro-thrombi and endothelial injury in relation to the lesion 🔺️🧵

h/t @ShaneyWright
Here link to the study | case report of 59 year-old man with proven exposure to SARS-CoV-2: his close contacts were positive, hospitalized, and 1 died from covid || the subject developed upper respiratory symptoms but was negative for SARS-CoV-2 testing

onlinelibrary.wiley.com/doi/10.1111/cu…
The patient subsequently developed a toe lesion which lasted for at least 22 months || the lesion was object of biopsy 16 weeks in || histopathology revealed evidence of vasculopathy i.e. damage and abnormal functioning of local vessels like capillaries

#LongCovid
Read 8 tweets
Apr 4
Further confirmation from Switzerland's press that #LongCovid after omicron is not uncommon at all, and potentially serious. We in the Long Covid grassroots movement and patient-led research have been reporting this since the beginning of the omicron wave

🧵
The reasons for us raising the alarm had been multiple. First, the immune escape features of the omicron variant. This variant is clearly capable of inducing symptomatic disease, or even death, including among those vaccinated or with prior infection. This was immediately clear
Second, the great ability of omicron to spread very fast and infect a large number of people in a matter of weeks. More people infected, more chances of #LongCovid. The omicron wave also took place in a phase of extremely poor pandemic management, with SARS-CoV-2 let to rip
Read 7 tweets
Apr 4
I've noted this, too. Sorry to be cynical but white male researchers suddenly "discovering" #LongCovid is simply due to the fact the phenomenon is now popular. They realized there is money, visibility, career prospects, funding, and consultancy in it
They weren't here in 2020
The huge push for the identification and recognition of #LongCovid was done by patients/ patient researchers. Most of them were women and some from minoritazed/ marginalised communities (with disabilities etc.)

@felicitycallard and myself on the story

sciencedirect.com/science/articl…
Patients and patient researchers (most of whom I repeat are women) are still those with the most knowledge. "New arrivals" from privileged academic circles, mostly white males, are sometimes approching #LongCovid as they approach academia in general: for propelling their careers
Read 7 tweets
Apr 3
Yup! We have been keeping lists of what covid | SARS-CoV-2 infection leads to. Follow hashtags like #LongCovid to find out. It's, basically, almost everything. A lot of data collated by patients themselves already in 2020

A non-exhaustive list

🧵
Autoimmunity (multiple types)
Heart disease | damage (multiple types)
Vasculitis (=inflammation of blood vessels, multiple types)
Endothelial dysfunction
Amputations
Lung transplant
Brain damage (multiple types)
Diabetes
Clotting disorders (multiple types)

#LongCovid
Damage to the placenta
Pregnancy loss
Impact on foetal development in utero
Acute kidney injury (AKI)
Chronic kidney disease
Viral persistence (= various forms, from replicating virus in the severely immunocompromised to viral "fragments" in various tissues)
Hair loss

#LongCovid
Read 10 tweets
Apr 3
Another study on the link between antiphospholipid antibodies and the risk of clotting ~ endothelial dysfunction in the later stages of acute, severe covid

An easy-to-read report | h/t @MeetJess 🧵

Some in the #LongCovid community have also reported antiphospholipid antibodies
A link to the original study here. The authors take a look at different biomarkers in the serum and plasma of 244 hospitalized covid patients || aim is to understand what drives endothelial dysfunction and clotting propensity in severe covid

pubmed.ncbi.nlm.nih.gov/35174669/
The endothelium is the thin lining of blood vessels and heart. There is massive evidence of endothelial dysfunction ~ activation in acute and #LongCovid. Some authors have defined covid itself as an "endothelial disease" already in 2020 | e.g.

pubmed.ncbi.nlm.nih.gov/32882706/
Read 4 tweets

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