1/ A lot of times polls like these are more interesting for the talk they generate than even the results themselves.

Here are a few featured comments and my added thoughts...
2/ A lot of people wanted greater specificity on what I meant by "rich" -- I left this more to the reader's interpretation. IMO, I'd have thought this would be in a highest quantile, such as top 1/3rd or 4th of typical aggregate diet.

3/ @MichaelMindrum mentioned the poll results might skew a bit too much toward expectation of SFA not causing CVD given those likely following my account -- I don't disagree.

Hence my interest in direct study on health conscious populations consuming high SFA (like many #LMHRs)
4/ @theproof made the following comment and I actually agree if all elements prove independently causal (⬆️SFA independently causal of ↗️ApoB + ⬆️ApoB independently causal of ↗️CVD, regardless of context).



(But again, further reason to study #LMHRs)
5/ Interestingly, it seems the pathology of saturated fat rests on these lipid changes (specifically, increased LDLp/ApoB)

In other words, I haven't heard of any other assertion of disease saturated fat is asserted to be specifically causal of thus far.

Anyone know of any?

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More from @realDaveFeldman

Apr 8
📊Polls ahead of #KetoSaltLake

Poll (1/4)
Lean Mass Hyper-responders (#LMHRs) are defined by:

+⬆️#LDL #Cholesterol at 190mg (5.17mm) or higher,
+⬆️#HDL-C 80 (2.07) or higher &
+⬇️#Triglycerides of 70 (0.79) or lower

In your opinion, cardio risk level of this profile is likely
Poll (2/4)
Many demonstrating the #LMHR phenotype (but not all) consume a diet...

High in animal protein
High in red meat
High in saturated fat

In your opinion, if we were to further stratify the #LMHR population to those with the above diet, their cardio risk level would be...
Poll (3/4)

When did you first hear of the Lean Mass Hyper-responder profile?
Read 5 tweets
Mar 9
1/ The scientist in me is looking forward to this new, real world data emerging on #HealthConscious #Carnivores.

It will help provide data that helps confirm/disconfirm the long standing assumption that "healthy user bias" has been effectively adjusted for by researchers...
2/ If you're not familiar with "healthy user bias" (HUB), it's a known potential confounder where those who are doing what they feel is healthy in one regard (such as avoidance of red meat), can often have other likewise "healthy habits", such as more exercise, less smoking, etc
3/ This is a big problem with epidemiology given the overlap is quite common.

To mitigate this, there are efforts to adjust for these confounders such as through statistical techniques (ie sensitivity analyses)
Read 6 tweets
Mar 8
1/ Yes! @NutritionMadeS3 -- please stay with this, it's important.

This goes back to what we were talking about last summer and why I keep drawing the distinction...

In fact, if you (and everyone else reading) would care to indulge me -- I'll unpack further...
2/ Let's definitely grant for a moment that ApoB containing lipoproteins (which we'll call ApoB-Lp) are participants in the process of ASCVD.

Can we likewise consider there are disease states (whether genetic or acquired) that result in both changes in serum ApoB-Lp *and* ASCVD?
3/ Monogenetic FH is certainly one I'd Put on the table.

In particular, a likewise constituent participant in the process of ASCVD are macrophages. Macrophages are nucleated immune cells and can thus suffer the same dysfunctional lipid metabolism we see with hepatocytes of MoFH.
Read 14 tweets
Feb 27
🎙An absolute *must listen*!!! 🎙

1/ This podcast episode via @HCTriage, the third in a series on #ScienceTransparency, the #ReproducibilityCrisis and how we got here is easily one of the richest, and most articulated explanations I’ve heard yet podcasts.google.com/feed/aHR0cDovL…
2/ Again, an incredible triumph in science communication by @crashcoursestan @olsenvideo @DrTiff_Phd among others.

👏 👏 👏
3/
@BrianNosek:
“The big challenge as we see it is that the values that we have for how we think science should operate are not aligned with the culture, the incentives, and the policy landscape for driving how science does operate.”
Read 8 tweets
Feb 23
1/ My thoughts on being a good #Moderator

First and foremost, your top goal is to service the debate, not your own opinions.

The best moderators are those who give no clue as to where they stand on the subject because it's their express duty to leave that to participants...
2/ All your interjections in the debate should come as no surprise to anyone -- especially the participants.

In other words, clearly define the rules in advance on what you'll be enforcing, and ideally, you should announce these to the audience at the beginning as well.
3/ Thus, if someone steps out of line for these agreed upon rules and you promptly enforce them, there should be no controversy as this was expected.

A "bad call" is always a problem in any sport, the losing side feels robbed, and even the winning side feels the victory tainted.
Read 7 tweets
Feb 22
Poll 1 of 4 (Please answer all four polls)

Which of these have the biggest association to heart disease?
Poll 2 of 4

What is the *second* biggest association to heart disease? (Choose a different answer from your first)
Poll 3 of 4

Which of these are the most discussed on social media in relation to heart disease?
Read 4 tweets

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