Thread by @nicknorwitz

We know Twitter has the potential to confuse messaging around sensitive topics, including those of our research on #LMHR Therefore, I want to play 20Q with you about our papers! All answers can be found in the manuscripts! Begin!
doi.org/10.3389/fendo.…
pubmed.ncbi.nlm.nih.gov/35106434/

Question 1: The definition of a lean mass hyper responder is

Question 2: If you suffer from type 2 diabetes, you're at elevated risk of exhibiting increases in LDL-C on a ketogenic diet because you're metabolically unhealthy

Question 3: We argue in our papers that the elevated LDL-C found in #LMHR is of little clinical relevance, i.e. that high LDL-C is safe in this population

Question 4: Which of the following lifestyle interventions appears to be most highly effective in lowering LDL-C in lean mass hyper-responders based on our recent the case series and case report?

Question 5: The title of the case report on subject LM mentions which of this following topics?

Question 6: In the case report, why was CT angiography ordered on the subject?
A) To provide evidence high LDL-C is safe in LMHR
B) To try to convince the patient, LM, to take medication
C) Because the patient requested a CTA
D) B and C
@Lpa_Doc

Question 7: In the case report, the CTA on subject LM was perfectly clean. From this we concluded:
A) the patient shouldn't take medication
B) more research needed on LMHR
C) the patient is at low lifetime risk for ASCVD

Question 8: In the case report on LM, when was LM's LDL the highest
A) When saturated fat intake was highest
B) When BMI was lowest
C) When dietary cholesterol intake was lowest
D) B and C

Question 9: In the LMHR cohort study, baseline LDL-C levels before low-carb diet among LMHR and non-LMHR were the same

Question 10: In the case report, the subject, LM, tried repeatedly to come off a therapeutic ketogenic diet in order to lower his LDL-C because he was concerned about the risk associated with high LDL-C.

Question 11: The proposed lipid energy model excludes the possibilities that fiber, genotype, or saturated fat intake can modify the the LMHR phenotype

Question 12: In our analysis of 70,310 patients in the NHANES 1999–2020 database for which there are LDL-C, HDL-C, and TG data, how many LMHR did we find?

Now things are gonna' get tricker. This is where we pick out the top students...

Question 13: In the cohort study, what were the pre-diet average LDL-C, HDL-C, and TG for LMHR?

Question 14: In the cohort study, what were the average LDL-C, HDL-C, and TG for LMHR on a low-carb diet?

Question 15: What is the difference between the mean BMI of LMHR and the mean BMI of an American in the NHANESIV dataset (hint: supplement)

Question 16: The day before we submitted the LMHR cohort study paper, co-author Dr. Adrian Soto-Mota was hit by a truck while in an uber and helped submit with a fractured spine because he is just that bad-ass

Question 17: Author, researcher, and LMHR, NGN suggests that everyone who is on the LMHR spectrum consider either coming off a keto diet or, if this is not possible, consider medication and work with their doctor to determine the best decision for them as an individual.

Question 18: (Opinion question/Poll)
If you are / were an LMHR, which would you do first?

Question 19: (Opinion question/Poll)
Do you feel further study on Lean Mass Hyper-responders is warranted?

Question 20: Did you learn something from these 20 questions? If 'yes' please comment with what you learned.