Dr. Jayakumar Rajadas on the striking similarities & possible therapeutic options for #LongCOVID & #LongLyme #LymeDiseaseAwarenessMonth 
Dr. Rajadas, a pharmacologist by training, finding doxycycline is not clearing infection in the lab. However, mitomycin & azlocillin are working well. Prefers fewest number of molecules as treatment option (1 or 2 at most). #LymeDiseaseAwarenessMonth
Rajadas finding TLR2 interaction in both Borrelia and SARS-Cov-2 surface proteins, also elevation of quinolinic acid. #LymeDiseaseAwarenessMonth
Rajadas, Borrelia is constantly shedding outer surface proteins. OspA forms amyloid aggregates. Amyloid leads to elevated quinolinic acid which has negative affects on the brain. #LymeDiseaseAwarenessMonth
Rajadas also finding OspC forms amyloid. Says the ideal treatment would kill the Borrelia burgdorferi spirochete and also clear the remaining debris including outer surface proteins. #LymeDiseaseAwarenessMonth
Rajadas "OspC is almost like a prion" #LymeDiseaseAwarenessMonth
Rajadas found a high levels of IL-6 produced by the immune system due to OspC. This creates a cytokine storm and affects the macrophages as well as compromising the T-cells. Disulfiram kills Borrelia and reduces inflamation #LymeDiseaseAwarenessMonth
Rajadas | The glycerol-3-phosphate dehydrogenases GpsA and GlpD constitute the oxidoreductive metabolic linchpin for Lyme disease spirochete host infectivity and persistence in the tick. #LymeDiseaseAwarenessMonth dx.plos.org/10.1371/journa…
Rajadas | This is how disulfiram is working against Borrelia #LymeDiseaseAwarenessMonth
• • •
Missing some Tweet in this thread? You can try to
force a refresh
