Discover and read the best of Twitter Threads about #LymeDisease

Most recents (24)

1/🧵For months I’ve been grappling with what seemed like a real gap in conversations about #LongCOVID.

Here in @statnews, I introduce you to 30 references & 3 #COVID survivors – Ray, Pam, and Carolyn – who taught me a lot. I hope you think so, too…

bit.ly/2Zb9S2J
2/ "I feel like I'm getting the silent treatment & it's killing me," #LongCOVID pt Pamela Bishop confided in me about her months-long interactions as she tried to get answers about a strange array of symptoms that have plagued her since recovering from #Covid19.

Pam then & now… Image
3/ Up to1 in 3 COVID survivors report experiencing #longCovid symptoms 3 to 6 months later. Their stories give me an extreme case of déjà vu because this is playing out similarly to the problem of long-term survivorship after non-COVID critical illness.
 
bit.ly/3vzcIdn
Read 25 tweets
Hello Twitter Friends,
Quick Poll: Did you go hiking or nature walks in the northeast or upper Midwest of the U.S. this summer? #nature #hiking #ph260720
If you answered yes, did you happen to meet my friend, Ticky? And did you know that ticks (specifically blacklegged ticks) are the main transmitters for Lyme Disease? #ticky #lymedisease #ph260720
Lyme Disease is caused primarily by the bacteria Borrelia burgdorferi. Lyme disease can be very unpredictable in the symptoms it can cause. Typical symptoms include fever, headache, fatigue, and a skin rash that can look like a bulls eye or “target” rash. #lymedisease #ph260720
Read 10 tweets
@OxMEDiscovery
1/7
From the Morten Group at Oxford:

"Our ME/CFS Raman diagnostic paper is just back from review. They like it! But we need to run a further set of expts with new blood samples. Really important we get the PhD funded in order to collect new bloods."
2/7
"In this proposal we will explore this association in detail in ME/CFS, Chronic Lyme and Long Covid examining not only the gut but also the currently unexplored blood biome."
3/7
"We propose that the blood biome and its association with a leaky gut could be a pivotal factor in a number of chronic conditions including #ME/cfs, #LymeDisease and #Long covid."
Read 8 tweets
Let’s discuss #LymeDisease #vaccines.

The topic is getting a lot of play lately, and I’m seeing people who have been socially programmed to hate “antivaxxers” jumping on the “antivaxxers killed the Lyme vaccines” propaganda short bus.

🧵
First of all, the #Lyme vaccines killed themselves. Let’s just be clear on that, once and for all. OspA in any form is not a vaccine. It is one of many lipoproteins expressed on the surface of Borrelia, the organisms that cause #LymeDisease. #LYMErix was recombinant OspA.
You can’t inject these lipoproteins… because…why would you do that when the ticks are perfectly capable??? 🤦‍♀️
Read 33 tweets
📢 Body Politic & our research partner @patientled explain President Biden’s announcement yesterday about #LongCovid disability rights in the US, with quick links to federal agency publications on #LongCovid that patients should bookmark. #ADA31
1/
wearebodypolitic.com/bodytype/2021/…
First, links to publications from federal agencies on #LongCovid yesterday:

- Guidance from DOJ & HHS ada.gov/long_covid_joi…
- For students & educators: www2.ed.gov/about/offices/…
- Employment support @USDOL dol.gov/agencies/odep/…

- @ACLgov resources acl.gov/sites/default/…
2/
One of the main takeaways:
awareness for people with #LongCovid who now realize they may be considered disabled under ADA, IDEA, etc. and therefore may be entitled to accommodations & services that make everyday life activities, work, and school more accessible.
3/
Read 20 tweets
New | Lyme arthritis: linking infection, inflammation and autoimmunity. #LymeDisease (a thread) 1/
nature.com/articles/s4158…
"In the USA, B. burgdorferi often disseminates in the blood during the first few weeks of infection in a process that requires the binding of Borrelia surface adhesins to host integrins on the vascular endothelium28–30. " 2/ Image
"As shown in mice, the spread of B. burgdorferi through the vasculature or lymphatics is dependent on the inter-actions of spirochaetal surface molecules and endothe-lial cell membrane proteins." 3/
Read 29 tweets
THREAD: I’m going to let you in on a little secret. In March 2020 millions of people across the globe- including a disproportionate number of healthcare workers like me- got in touch with each other and signed a pact. We all decided to fake a new illness.
We started exhibiting a bewildering array of seemingly disconnected symptoms reproducible between individuals. Chest pain, fatigue, breathlessness, brain fog. Blood tests, x-rays & ECGs were usually normal. #MedTwitter take note. This means it’s in the head.
Some of us were able to make our pulse rate, blood pressure and oxygen saturations fluctuate wildly, foxing doctors. In fact, some got so good at this game that we could fake damage to heart muscle on MRI & produce weird rashes & antibodies on demand.
Read 10 tweets
Different groups have FOIAed this #Lyme crooks email over the years. On the surface it is appalling, but what does it really mean? “This battle cannot be won on a scientific front...we need reinforcements from outside our field.”

In short, it means they’re guilty. Of what? 🧵
They rigged the #LymeDisease case definition to conform to diagnostics that were designed to detect a small minority of cases that are genetically predisposed to produce a strong antibody response.
Allen Steere had done a ton of research on the association of various HLAs with different antibody responses in #LymeDisease. Everyone knew by the early 1990s that the people with an arthritic knee had a strong immune response but weren’t very sick.
Read 21 tweets
Thread: A major barrier to progress in understanding the neurologic manifestations of #LymeDisease has been a lack of a tractable laboratory animal model to evaluate the mechanisms of central nervous system pathogenesis.
For decades we have seen study after study of Lyme arthritis. As it turns out the most frequently reported Lyme symptoms are neurological symptoms: memory loss and cognitive impairment, sleep impairment, psychiatric manifestations, headaches, neuropathy and more. 2/
This is the first study, to my knowledge, that shows how Borrelia burgdorferi gets into the central nervous system, how the immune system responds, and how the bacteria adapt to the immune system. #Lyme
Meet the researcher Catherine Brissette, Ph.D. globallymealliance.org/meet-researche…
Read 15 tweets
Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
Read 34 tweets
1. Many people suffering from long-term #COVID19 symptoms are being told - it's just anxiety, it's acid reflux, there's nothing wrong with you - even as research shows COVID-19 damages the heart, brain, & vascular system. Why is this happening?
2. This is the first time this virus has invaided the human body. We are just learning how it spreads, how it attacks the body, and the damage it does to our health. COVID-19 patients are first-hand experts in this new disease. So why do they encounter so much disbelief?
3. This disbelief has happened many times before. #LymeDisease, #chronicfatigue, Post-intensive Care Syndrome, and so many other diseases are life altering for those who have it. And met with skepticism by those who don't. COVID-19 is novel and world-wide, but here we are again.
Read 8 tweets
More than two decades after assaulting Czech children with lipidated OspA “vaccines,” UConn declares, “It’s the lipids, stupid!”

“Chemical removal of the lipid portion of purified M. pneumoniae lipoproteins eliminated VED...”[vaccine-enhanced disease]

scienmag.com/uconn-research…
WHY do “scientists” still think it’s cool to inject lipoproteins (especially of the highly acylated variety)? WHY is UConn suddenly saying, oh, isn’t it amazing how we solved the mystery of the century! WHY???

Because #LYMErix.
We had a #Whistleblower for that, and she, @KMDickson, got the standard whistleblower treatment so the #pharma criminals wouldn’t have to answer for their crimes. And here we are 20+ years later, with one of the same institutions involved in the OspA scam telling us #lipidsbad 🤬
Read 7 tweets
When will @GovCanHealth update website to acknowledge mom to baby transmission #Lymedisease? Alberta Health does, CDC does, Health Canada officials did in 1988. Why take pause in alerting 🇨🇦 to what has been known + documented since 1985? See thread /1
open.alberta.ca/dataset/58776f…
Is there evidence that Borrelia burgdorferi, the agent of Lyme disease can be transmitted from an infected mother to her baby? YES! Below my 2019 presentation for
@ilads_lyme. Not sure how much more #evidence is needed to acknowledge the risk. /2
Can Borrelia burgdorferi cross the placental barrier + transmitted in-utero? /3
Read 31 tweets
Chronic illness in #LymeDisease is shockingly common. This occurs more frequently if #Lyme is first diagnosed and treated at a later stage, but occurs at every stage of the disease.👇@Lymenews @BayAreaLyme @LymeChallenge @danaparish @ProjectLyme @lymelegacy @LymeOntario
Even for early #Lyme (erythema migrans stage illness), a study by Johns Hopkins demonstrated that about 40% did not get regain their health at 6 months after treatment.👇@LymeAlliance @Lyme_Connection @liv_lyme @UKLyme @AdvocatLyme @LymeDiseaseLDA pubmed.ncbi.nlm.nih.gov/23462300/
A study from Danbury Hospital in CT demonstrated that 61% of patients still had their initial Lyme symptoms 6-12 months after treatment for early Lyme, (erythema migrans stage illness). @LymeDiary @LymeDiseaseAus @LymeAction @LymeDiseaseNYC pubmed.ncbi.nlm.nih.gov/24970880/
Read 14 tweets
New | Phylogeography of Borrelia spirochetes in Ixodes pacificus and Ixodes spinipalpis ticks highlights differential acarological risk of tick-borne disease transmission in northern versus southern California. #Ticks #LymeDiseaseAwarenessMonth ncbi.nlm.nih.gov/pmc/articles/P…
Between 2008–2015, 11,066 adult and 3,815 nymphal I. pacificus were collected from 42 California counties. Borrelia burgdorferi sl was detected in 1.2% and 3.8% I. pacificus adults and nymphs, respectively. #LymeDisease
"B. burgdorferi ss was not detected in ticks tested from southern California. In contrast, Borrelia bissettiae, a member of the B. burgdorferi sl complex, was detected in both I. pacificus and I. spinipalpis, in the coastal region of both northern and southern California"
Read 3 tweets
Die übliche Darstellung der Verläufe von #COVID19 ist zu zweidimensional: am Ende ist man NICHT entweder gesund oder tot.

Viele Pathogene können zu schweren chronischen Leiden wie #MECFS führen: Diese Patienten überleben den akuten Infekt, verlieren aber trotzdem ihr Leben. 1/
Eine 2006 in Australien durchgeführte Studie hat gezeigt, dass ganze 11% der an Pfeifferschem Drüsenfieber, Q-Fieber oder Ross-River-Fieber Erkrankten sechs Monate nach der akuten Infektion an #MECFS litten. 2/

ncbi.nlm.nih.gov/pmc/articles/P…
Nach dem Ausbruch von SARS in 2003 entwickelten viele Patienten ein sog. "post-SARS-Syndrom", das symptomatisch weitgehende Übereinstimmung mit #MECFS aufweist. 3/

bmcneurol.biomedcentral.com/articles/10.11…
Read 108 tweets
1. thread: #coronavirus and #MECFS

We know that #MECFS can be triggered by a range of viral pathogens

So it is likely that #coronavirus could trigger a worldwide spike in ME/CFS in the next 6-18 months

@bmj_latest
bmj.com/content/333/75…
2. Post-infection #MECFS has been reported following infection from brucellosis, #EBV (mononucleosis), #LymeDisease, Q-fever, Ross River virus, viral meningitis, dengue fever and...

sciencedirect.com/science/articl…
bmj.com/content/333/75…
3. ...an increased risk of developing #MECFS has already been associated with a previous viral #pandemic

This study found that young/healthy people were just as likely as the elderly to develop #MyalgicE following in an #influenza pandemic

#coronavirus
sciencedirect.com/science/articl…
Read 8 tweets
Borrelia burgdorferi DO NOT secrete toxins or other virulence factors. Lyme disease is both proinflammatory also immunomodulatory & immunosuppressive. What causes #LymeDisease is the immune response to the bacteria, not the bacteria itself.
The difference in severity and spectrum of #LymeDisease varies among patients. The reasons for this variation include different tropisms among B.b. strains and differences in the host immune responses. 👇 Image
The most commonly prescribed antibiotics for Lyme disease aren't that effective at killing Borrelia. Even combinations of these Abx have a hard time eradicating.
Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells aac.asm.org/content/59/8/4… Image
Read 8 tweets
Ever shattered an orange using liquid nitrogen? That's how we get DNA out of ticks in our new @FrontiersIn article frontiersin.org/articles/10.33… @UMassMedical @broadinstitute @karlssonlab
We have a lot of ticks. 1000s & 1000s of ticks. People send them to us as part of our #citizenScience #tick disease study ProjectAcari.org. The problem? getting the DNA out.
We want to use high-throughput #DNA sequencing to find out everything we can about each individual #tick - its species, its intestinal #microbiome (they have one too!), and if it carries dangerous pathogens.
Read 20 tweets
My thoughts on late manifestations of Lyme disease (Stage 3 "Chronic Lyme") & major histocompatibility complex (MHC)
Expression of MHC decrease in Langerhans' cells in the skin of patients with acrodermatitis chronica atrophicans #LymeDisease onlinelibrary.wiley.com/doi/abs/10.104…
Despite a strong immune response against B. burgdorferi the infection can become chronic, even after several courses of antibiotic treatment. #Lyme arthritis is one of those manifestations.
Read 19 tweets
For the millions of Americans who suffer from Lyme Disease:

newsweek.com/pentagon-weapo…
Does anyone believe the Pentagon will admit if they did release weaponized ticks? #LymeDisease
rollcall.com/news/house-ord…
It was the Pentagon who brought Nazis to the United States and experimented with poison ticks dropped from planes to spread rare diseases.

#LymeDisease

counterpunch.org/2019/08/14/lym…
Read 3 tweets
New | Evaluating the effectiveness of an integrated tick management approach on multiple pathogen infection in Ixodes scapularis questing nymphs and larvae parasitizing white-footed mice. #ticks #LymeDisease
link.springer.com/article/10.100…
WOW! I. Scapularis: "90% reduction in the combined deer removal, Met52, and fpronil rodent bait box treatment and 93% reduction in the combined Met52 and fpronil rodent
bait box treatment"
cc @thetickguy
@thetickguy "Compared to control, the Met52 and fpronil rodent bait box treatment combination reduced the encounter potential with a questing nymph infected with any pathogen by 53% and with a B. burgdorferi-infected questing nymph by 57%."
Read 3 tweets
New | Changing of the guard: How the Lyme disease spirochete subverts the host immune response. jbc.org/cgi/content/lo… via @jbiolchem
@jbiolchem "One of the many fascinating features of this unique pathogen is an elaborate system for antigenic variation whereby the sequence of the surface-bound lipoprotein VlsE is continually modified through segmental gene conversion events." #LymeDisease
@jbiolchem "This perpetual changing of the guard allows the pathogen to remain one step ahead of the acquired immune response, enabling persistent infection." #LymeDisease
Read 8 tweets
New | A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use. #LymeDisease jcm.asm.org/content/early/…
New microfluidic assay (mChip-Ld) detects B.b. antigens: VlsE and a proprietary synthetic 33-mer peptide (PepVF) to capture sensitivity in all disease stages, and OspC for early Lyme disease. Provides results in as little as 15 minutes. #LymeDisease
With specificity set at 95%, the sensitivity of mChip-Ld ranged between 80% (95% CI: 56% to 94%) and 85% (95% CI: 74% to 96%) for two panels of early Lyme disease, and was 100% (95% CI: 83% to 100%) for Lyme arthritis.
Read 5 tweets

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