1/Last weekend at @MetabolicSummit was incredible. Really fantastic speakers and guests discussing metabolism research around microbiome, circadian cycles, muscle mass and longevity (shout out @DrRagnar) and yes, even #LMHRs got lots of airtime (props to @bschermd & @JaimeSeeman)
3/ Also, the Gala event Saturday night was bitter sweet opening with a recent, yet very inspiring interview from @DrSarahHallberg before her passing, but ending with a packed dance floor and music to finish the night.
4/ Lastly, I want to give a special shout out to my good friend and colleague, @siobhan_huggins. Thanks for the extra arm twist to come — it was worth the added schedule-tightening.
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2/ ... Hence the importance of the #LMHRstudy (still recruiting, btw -- see LMHRstudy.com for details)
In the mean time, we regularly and often emphasize everyone should work with their doctor and understand the guidelines recommend against high cholesterol...
3/ ... There are many like this pt who are in the unusual position of having a severe medical condition that appears to be uniquely resolved through a very carb restricted diet.
With respect, the patient didn't immediately refuse any form of treatment...
1/4 Retweeting via @Lpa_Doc -- click within to read 3 part thread. 👇
Also, per our video abstract:
"We remind viewers that existing guidelines and every major scientific institution around heart disease strongly advises against high cholesterol levels."
2/4 And,"While these data on our patient are comprehensive and provide potential new insights, they are limited in scope and timespan. It’s certainly possible this patient is an outlier, or that their progression of plaque will take place later, or many other such possibilities."
3/4 In short, while we appreciate the opportunity to explore the Lipid Energy Model (#LEM paper forthcoming) and share novel data (such as this case study), we continue to emphasize this is uncharted territory and largely considered substantially risky within Lipidology.
2/4 ... "This proportion was similar to that in patients with lower LDL-C levels. Third, CCTA-ascertained absence of CAC indicated no detectable plaque in 86.8% of patients, including those with LDL-C levels greater than 190 mg/dL."
3/4 To be sure -- "However, the prevalence of noncalcified plaque increased with higher LDL-C levels."
This isn't too surprising where not stratifying for metabolic health and other such higher associative indicators at those levels...
2/ A lot of people wanted greater specificity on what I meant by "rich" -- I left this more to the reader's interpretation. IMO, I'd have thought this would be in a highest quantile, such as top 1/3rd or 4th of typical aggregate diet.
3/ @MichaelMindrum mentioned the poll results might skew a bit too much toward expectation of SFA not causing CVD given those likely following my account -- I don't disagree.
Hence my interest in direct study on health conscious populations consuming high SFA (like many #LMHRs)
1/ The scientist in me is looking forward to this new, real world data emerging on #HealthConscious#Carnivores.
It will help provide data that helps confirm/disconfirm the long standing assumption that "healthy user bias" has been effectively adjusted for by researchers...
2/ If you're not familiar with "healthy user bias" (HUB), it's a known potential confounder where those who are doing what they feel is healthy in one regard (such as avoidance of red meat), can often have other likewise "healthy habits", such as more exercise, less smoking, etc
3/ This is a big problem with epidemiology given the overlap is quite common.
To mitigate this, there are efforts to adjust for these confounders such as through statistical techniques (ie sensitivity analyses)