Lissa Bauer Profile picture
May 13 12 tweets 7 min read
Now to talk about Phosphatonins and #phosphorus metabolism/bone disease by Dr. Kumar moderated by @sfeirjad...I'm ready to learn since admittedly I know little of this #AACE2022 #Endotwitter #bone Image
Why bother about phosphorus? Well it plays many roles in cellular signaling and maintenance of membrane structure of #bone. Low concentrations associated with rhabdo, decreased cardiac function and bone dysfunction (#osteomalacia, #rickets). low and high phos causes bone disease ImageImage
High Phos Concentrations are Associated with CV Disease and Excess Mortality in CRF and decreasing levels reduces CV mortality ImageImage
There are many different regulators to phos homeostasis. Not surprisingly since we are talking endo & bone here, there are many impt players to help maintain normal serum phosphate levels especially in dietary phos ImageImage
What are causes of #hypophosphatemia, there are many Image
What is a phosphatonin? -- my exact question when I saw the lecture title -- factors that play a role in phosphate homeostasis -- common one we know is FGF-23 ImageImage
Image
The phosphatonins FGF-23 and sFRP-4 reduce renal phos reabsorption By reducing the number of Na-Pi IIa
transporters on the surface of renal tubular
epithelial cells Image
The Phosphatonins FGF-23, sFRP-4 and FGF-7 Reduce 1α, 25- Dihydroxyvitamin D Production by
Inhibiting the 25-Hydroxyvitamin D 1α-Hydroxylase --- there is a feedback loop Image
Why do we care? Well it's b/c when there is too much phosphatonin activity you get hypophosphatemia and bone disease (TIO, XLH, ADHR, renal failure etc) ImageImageImage
The opposite (hyperphosphatemia) happens when you don't have enough phosphatonin activity Image
Now how to use this clinically? History is impt and lab evaluation -- refer to the third slide attached below as it is a great reference on expected lab changes in different hypophosphatemic conditions ImageImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Lissa Bauer

Lissa Bauer Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @lissabauer

May 13
Excited to hear this talk about Time-Restricted Diets by Dr. Grajower moderated by @theweightmd I'll try to share what I learned #AACE2022 #endotwitter Image
What are time restricted diets? We are using intermittent fasting incorrectly -- most are actually doing time restricted eating Image
Image
Read 5 tweets
May 13
Let's hear The Evidence For and Against Combination #Thyroid Hormone therapy by Dr. Bianco #AACE2022 #Endotwitter. This conversation is controversial here are some of the main slides Image
Patient's on Lt4 reporting a lot of residual symptoms in energy, cognition ImageImage
Normal physiology the majority of thyroid hormone production is T4 (16:1 T4:T3) and gets converted peripherally to T3 (5mcg made in thyroid, 25mcg made peripherally) Image
Read 9 tweets
May 13
Starting day 2 #AACE2022 with @ArchanaSadhu talking to us about #diabetes technologies in 2022 #endotwitter
Look how far we have come in #diabetes technology and there is still a lot more to go #AACE2022. #CGM technology has been a game changer and the accuracy continues to improve with each generation
So what's new in the pipeline for #diabetes technology? Let me tell you starting with #dexcom G7. It will be smaller with a better MARD, better warm up and ALL-IN-ONE applicator and transmitter! Just pending FDA review #AACE2022 #endotwitter #medtwitter
Read 11 tweets
May 12
The third lecture of the series of NAFLD by Dr. Cusi - Fatty liver guru -- presenting on Current and future treatments
Pioglitazone decreases visceral fat (liver fat, CV fat, muscle fat) but increases SQ fat. Effective at decreasing NASH and fibrosis
Read 8 tweets
May 12
Diagnostic tools for diagnosis of #NAFLD and complications by Dr. Lomonaco #AACE2022 #endotwitter
#NAFLD has effects on other conditions including DM, CVD, CKD etc due to increased hyperinsulinemia, insulin resistance, proinflammatory factors etc
How do we screen for #NAFLD and find the ones with fibrosis? A lot will be missed if just checking transaminases. FIB-4 and NFS is a better screening tool
Read 8 tweets
May 12
Fantastic lecture by @scottisaacsmd on the Fatty liver epidemic and introduction to the new AACE Fatty Liver Guidelines released today. First lecture by @scottisaacsmd #AACE2022 #endotwitter
NAFLD is a spectrum that includes NASH. First rule out secondary causes.
Difference between NAFL and NASH? NAFL is just the accumulation of fat w/o ballooning or much inflamation. NASH has hepatocyte changes from ballooning and inflammation. IIt is staged also based on fibrosis (F0-F4)
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(