Dr Elisa Perego Profile picture
May 16, 2022 16 tweets 8 min read Read on X
I'm a bit exhausted to repeat this. But #LongCovid | covid are among the best studied diseases in history. In addition to the sheer amount of studies, a lot of research has been done with some of the most advanced techniques in biomedical research. Let's have a look!

🧵
Brightest X-rays on Earth expose covid damage to the lung | the innovative imaging technique can pick up micrometre-scale of organs

@Nature | November 2021

nature.com/articles/d4158…
In @NatGeo | January 2022 | a long but accessible read on the implementation of cutting-edge technology and scanning techniques to explore the vascular nature of covid

nationalgeographic.com/science/articl…
Another cutting-edge scanning technique, polarized Xenon MRI, has revealed long-term damage to the lung after SARS-CoV-2 infection

#LongCovid

sheffield.ac.uk/news/study-con…
Shotgun total sequencing DNA analysis of stools from covid patients, weeks after onset => perturbations of gut microbiome composition, linked to disease severity

Alterations connected with inflammation markers in bloodwork

#LongCovid

@bmj_latest

gut.bmj.com/content/70/4/6…
Abnormalities in the oral microbiome have been identified in #LongCovid patients, potentially linked to an abnormal immune response and a pro-inflammatory status following SARS-CoV-2 infection

umassmed.edu/news/news-arch…
Blood DNA methylation and outcomes in COVID-19

…lepigeneticsjournal.biomedcentral.com/articles/10.11…
The role of mass spectrometry in defining different covid phenotypes (sub-types) and other key clinical challenges in the pandemic

frontiersin.org/articles/10.33…
The application of mass spectrometry reveals a prolonged inflammatory status in #LongCovid

pubmed.ncbi.nlm.nih.gov/33391730/
Gene expression changes in acute covid may have an impact on the development of #LongCovid

news-medical.net/news/20211006/…
This is just a short thread to show how some of the most innovative techniques available on earth have already been applied to covid and #LongCovid since 2020 and 2021. Surely, further research can be developed! Not all available studies will be perfect or leading to treatment
However, even this brief review shows that claims that covid and #LongCovid are "mysterious" entities are unfounded. There is a lot of research going on. We need to translate research into treatment. But the knowledge is being built right now.
People, especially those with a degree in medicine, or those employed in academic or research positions, should really work on reading the publications in their own field before speaking about #LongCovid as "rare" or "mysterious". Alternatively, they can simply avoid the topic!
I add here another 🧵 I have been compiling with many publications on #LongCovid including cardiovascular disease, and many other effects in multiple organs. I hope it's useful to keep up with growing data on the disease

And I add here another 🧵 on cardiovascular disease and complications in #LongCovid
With a lot of publications and case studies

And I add here another 🧵 on #LongCovidKids the long term effects of SARS-CoV-2 infection on children. There are many publications on this topic too. Long Covid in children is also increasingly documented and studied

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More from @elisaperego78

Apr 17
A kind reminder to policymakers etc. making promises now, that you have *already* let Long Covid patients down. You're too little, too late. Long Covid was openly recognised by WHO in August 2020. People have died since. You might even have participated in "let it rip" dynamics
The Covid pandemic is one of the greatest health disasters in modern history. A preventable disaster, I'd suggest. An estimated 20-30 millions have died. An estimated 400 millions have experienced #LongCovid. We knew how dangerous SARS-CoV-2 was in 2020

osf.io/preprints/soca…
Despite extensive knowledge on the dangers of SARS-CoV-2, including Long Covid, we had in 2020, this dangerous SARS virus was left to rip. There was no appropriate enough answer to the Long Covid crisis. Of course, research is extensive, but access to diagnostics and care, isn't
Read 5 tweets
Apr 17
A kind reminder that the persistence of SARS-CoV-2 has been posited and increasingly demonstrated (at least in a number of subjects) since 2020—1. Long Covid patients and patient-researchers have been at the forefront of this. Policymakers are late.
While we need to fully elucidate the impact of SARS-CoV-2 persistence (with different manifestations) on human health (especially in the long-term), the precautionary principle should have been in place, including in view of data emerging since 2020, and data on SARS-CoV-1 (SARS)
Policymakers were alerted early about the possibility of viral persistence; and research on the topic has only been accruing over time. They should have acted much faster, both in terms of preventing new infections; and planning how to treat patients when persistence is proven
Read 7 tweets
Apr 16
We're in the most devastating pandemic in one century, with an estimated 20—30 million dead; an estimated 400 millions to have experienced #LongCovid; immune dysfunction; and a surge in other infectious diseases. It's not over. This is a key reason why people are so often sick
Bibliography as usual. Excess mortality from Covid at ~30 million dead. Additional estimates in such range (20 to 30 millions) by WHO, and others (a review in Perego 2023b, attached)



wsws.org/en/articles/20…
osf.io/preprints/soca…
Estimated cases of #LongCovid at 65 to hundreds of millions by Davis et al 2023; Altmann et al. 2023; Chen et al. 2022; WHO 2023. A review in Perego 2023b, attached

osf.io/preprints/soca…
Read 13 tweets
Apr 13
Usual reminder that "living with Covid" policies need the erasure and minimization of #LongCovid to be effective. People wouldn't accept themselves and their children to be be mass infected with a SARS virus if they were fully aware of the risks
People with a glaring conflict of interest, such as minimizing of the pandemic threat, have all the interests in minimizing/erasing #LongCovid, as they could be held accountable for the damage their policies caused to the global population, including children
A glaring case in point is Australia's Queensland CHO Gerrard, who deemed infection with SARS-CoV-2 "necessary" in late 2021 (with devastating consequences) and recently claimed we should stop using the term #LongCovid altogether. Conflict of interest

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Read 8 tweets
Apr 7
The desperate fight by policymakers like Queensland's CHO to drop the term #LongCovid is evidence of the term's power and efficacy, and of our activism. They wouldn't need to fight so hard and try to mobilize the press otherwise. I'll keep using the patient made term Long Covid
Policymakers and pundits who have been involved in minimizing the dangers of SARS-CoV-2 infection, obviously, have a great interest in dropping a term, Long Covid, which has been so useful in drawing attention to the long-term damage from this infection

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We were right in 2020. We are right now. They have been wrong across the pandemic. They're wrong now. SARS-CoV-2 infection is far from benign. Covid is far from being a two-week disease, harmless in the 'young and healthy", "mild" and harmless in children
Read 5 tweets
Apr 6
No. #LongCovid is a multi-system, heterogeneous disease entity which is proven to be disabling, life-threatening, even fatal in a subset. "Light rehabilitation" won't treat it. Please do better, especially if you're a public figure with degrees in medicine/adjacent fields
Choosing to highlight a flawed, small-scale study on #LongCovid from a big platform, rather than the thousands of research papers that document severe pathology down to the cellular level, is wrong. Policymakers and medical professionals must do better.
People with Long Covid deserve better, including because so many are victims of erroneous pandemic policies. Policies brought on us by the same policymakers who are now trying to minimize the severity of the disease, including it's potentially fatal nature (scientifically proven)
Read 8 tweets

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