We've known covid and #LongCovid have a significant endothelial, thrombotic and cardiovascular component since early 2020. As per Long Covid, this was initially brought to wide attention by the patient community
We have been discussing this online since early 2020, among the many living with #LongCovid already. This work has often been done via chats, tweets etc., namely beyond the official "channels" of medicine. It remains poorly acknowledged and poorly recognized
Yet, papers by patient teams were drawing attention to the cardiovascular and thrombotic potential of #LongCovid already in 2020 "mild manifestations in the prodromal stage may progress to severe disease and sequelae including cardiovascular and thrombotic .." (Perego et al 2020)
We've been working on this by starting from our own clinical data, the knowledge developed within the #LongCovid patient community, mounting evidence produced by conventional researchers, and the informal data we had from early epicenters, like Lombardy
One key question is why such knowledge developed by some patient researchers on #LongCovid, as well as by conventional scientists on acute covid since early 2020, was not picked up appropriately by health bodies, medical professionals, and "experts"
Lives have been lost and people have developed long-term, possibly permanent damage because of refusal to acknowledge the reality of covid | #LongCovid early on, beyond some segments of the patient community. The wrong "experts" have been listen to, apparently
It is not positive, in addition, to see presumptive "experts" to portray #LongCovid as "rare" or "mysterious", or "ill defined", when a huge amount of knowledge was already available in 2020, and 2021 at the latest
I remain grateful to all of those in the patient community and allies in conventional (i.e. non patient) research, who have been providing support, uplifting the voices of sufferers, and recognizing the importance of patient-led expertise in biomedical research
The role of cardiovascular disease in #LongCovid has been also underlined very early on by the #apresJ20 movement in France, with the @apresj20 association on the frontline for their advocacy and recognition of patient led expertise
@CovidSolidarit1 of course. There are many others just can't mention anyone and there also privacy reasons. But a big thought and thanks to all of those who have been fighting for recognition since day 1
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Ok someone said it before me! What about Long Monkeypox. Didn't know if it was in good taste to talk about it so soon. But we learnt the hard way to consider morbidity, not only mortality
Anyway, #monkeypox has known long-term health effects and complications as per @WHO
Reported complications of historical cases of #monkeypox | i.e. before current cases | include secondary infections, bronchpneumonia, sespis, encephalitis, and infection of the cornea, with resulting loss of vision
Asymptomatic (subclinical | "silent") infection is also noted to occur. #monkeypox as a symptomatic disease can be prolonged in itself, with symptoms and signs reported to last for 2 to 4 weeks according to official guidelines | a bit of deja vu here with the early covid reports!
Happy to see a good discussion of #LongCovid in Italy's primetime TV news @tg5med | not perfect, but excellent to see the cardiovascular and cardiopulmonary sequelae openly mentioned, among others | including footage of scanners
There has been sometimes a poor depiction of #LongCovid in some Italian venues (with a focus on "fatigue" etc. but not the most severe organ damage, which we know it's not rare even in young people with "mild" disease at onset). The news could have been more explicit about this
But it's still a step forward in respect to less explicit information, provided by some television venues in various occasions (TG5 itself wrongly mentioned #LongCovid lasted only 3 months a few days ago!)
This is a key point => search on online repositories (like PubMed) of #LongCovid papers. Lack of use in some papers of the most-known and most-used term = Long Covid! makes it more difficult to find research which avoid using "Long Covid" itself. Key connections are lost
Co-authors and I addressed the importance of using #LongCovid in a very recent piece out in @LancetRespirMed
Losing information is another issue to highlight and I thank @robert_leaman for mentioning it above 🔝
Thanks for sharing my thread on covid | #LongCovid!
This was a thread specifically focusing on some of the most cutting-edge techniques used to study the disease. For example, groundbreaking imaging, or the study of gene expression ~ dysregulation
There is much more research going on on both acute and #LongCovid. A lot of this research is based on less powerful, but more accessible techniques, like the SPECT scan to study lung damage, or various kinds of cardiac tests, to assess heart function.
Studies have now started to cover the 2-year period, which have elapsed since when covid appeared. A follow-up of the early patients from China recently published in @LancetRespirMed, has revealed a significant disease burden two years from infection in that group
The Bank of England openly addresses the impact of #LongCovid on workforce and labour dynamics
I've been writing this since 2020 but I do it again: Long Covid is a disaster in the making. It'll affect public health and economy for decades to generations bankofengland.co.uk/speech/2022/ma…
The range of covid damage to the body is vast and not uncommon, especially in those who aren't vaccinated. New variants are increasingly able to evade prior immunity including from the vaccine. Policy makers still fail to appreciate the longest term impact of covid
Viruses are already implicated in the development of cancer, neurodegenerative diseases, multiple sclerosis, autoimmune diseases and cardiovascular diseases, to name just a few. We are infecting and reinfecting half of the globe with a virus which has already killed 15 millions
Real experts on covid, not just "some scientists now", have been warning about this for ages. CoV-2 is a fast mutating, fast spreading SARS virus. It's been evolving fast since the beginning of the pandemic.
We've known since omicron appeared that it was good at evading immunity
We know now that omicron sub-lineages like BA.4 and BA.5 are even better at evading prior immunity, including from the fist omicron.
The European "CDC" has already upgraded them to variants of concern a few days ago.
Yes, multiple waves and re-infections are totally possible
There is no need for "draconian lockdowns" and the like (unless we get really submerged). We can control this pandemic with tools like airborne prevention, masks, optimal vaccination, improved treatment and communication, top surveillance, contact tracing, and clean air