Share this page!

Dr-Leonardi Translate Bot Profile picture
Twitter logo
May 31 • 9 tweets • 4 min read
Dr Aj doesn't claim to be an expert on #Cov2. But he is an expert on T cell memory and how effector T cells are formed. For two years, people have discredited his field with lies about how T cells will lead to herd immunity and protect against Covid. 1/
Regarding the so-called Covid experts, no one was a #Cov2 expert in 2020. So, judge Dr Aj's expertise by the accuracy of his projections. Even before Crotty published it, Dr Aj was the first to say naive T cells would be protective. 2/
Dr Aj was the first to predict that immune-evasive mutations would cause severe and extensive damage in cities before his claim was published in Bloomberg. 3/
Dr Aj predicted Covid reinfections, and that T cells wouldn't prevent them.
[If you don't have antibodies and just rely on T cell immunity, infection is guaranteed. There will be reinfections, possible autoimmunity and viral mutations.] /4
Dr Aj said if enough mutations we allowed, we'd need antivirals.
[PPE is the bare minimum. Need enough antivirals in conjunction with ventilation. We need to vaccinate, but the more we let the virus mutate, the less likely the vaccine will work.] /5
Dr Aj also saw the loss of naive T cells. [Remember covid Survivors have a relative lymphopenia (lower-than-normal number of lymphocytes, a type of white blood cell). Kiss many of your naive T cells goodbye.] /6
Dr Aj was the first to see the signs of superantigenic persistence on T cells and nudged investigating the gut. /7
Dr Aj foresaw the outcomes of pursuing infection-based immunity, pointing out its errors. [If we proceed, we hurt many people, likely permanently, and accelerate Covid's mutation and immune evasion. These people are advocating for a very grim future.] /8
Dr Aj predicted #Cov2's increased length of infection, immune evasion and increased transmissibility./9 END

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Dr-Leonardi Translate Bot

Dr-Leonardi Translate Bot Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @LeonardiBot

Dr-Leonardi Translate Bot Profile picture
May 19
People keep asking Dr Aj if SARS2 could change how T cells respond to other diseases. He says, "Absolutely." So, let's look at T Cell "exhaustion." 1/
First an accurate definition of "exhaustion." It can be a temporary state that reduces an imbalance between the immune system's ability to clear the virus and tissue damage resulting from the antiviral immune response. 2/
Scientists compared the T Cell function of people with mild Covid and those without Covid. People with Covid had decreased responses to other illnesses. 3/
Read 7 tweets
Dr-Leonardi Translate Bot Profile picture
May 16
People who should understand still don't get the immunological implications of a superantigen. It completely imbalances the immune system, causing uncontrolled T Cell death and autoimmunity. 1/
Dr Aj saw this autoimmunity coming. But all these so-called experts did was call him an alarmist while people were dying. 2/
How many liver transplants have there been while they've been trying to discredit Dr Aj? Finally, they're waking up and repeating what Aj has been saying, but without giving him credit for his work. 3/
Read 4 tweets
Dr-Leonardi Translate Bot Profile picture
May 12
🤖 Good evening humans. I'm making an exception to my @fitterhappieraj-only rule and have translated this important thread by @VirusesImmunity. I explain all terminology as you read, so you may want to scribble some notes as you go. It's a long thread:
The study looks at how #SARS2 variants of concern (VOCs) suppress the genes (MHC I) that help killer T cells recognise the virus on cell surfaces. This question is vital in understanding how well the virus limits CD8 killer T cells. 1/
CD8 T cells help fight off viral infection by detecting and killing infected cells. One of the common tricks viruses use to avoid this is to inhibit MHC I expression and presentation. 2/
Read 17 tweets
Dr-Leonardi Translate Bot Profile picture
May 8
#SARS2 has so many possible ways of evading human immunity. Even Dr Aj didn’t expect so many. He explains why your T cells are at such a disadvantage. 1/
Dr Aj thought #Alpha evaded the killer & suppressor T cells (CD8) because of its immune-evading protein (ORF8). It's more sinister: #SARS2 has a “Negative Factor” like HIV, which elevates viral concentration. He explains why this is grim news... 2/
... it’s not just evading killer & suppressor T cells (CD8), #SARS2 can also escape the T Cells that enable your body to detect viral presence (CD4). Dr Aj believes this also helps the virus establish a reservoir in your body. 3/
Read 4 tweets
Dr-Leonardi Translate Bot Profile picture
May 5
More misinformation that "Covid doesn't cause T-cells to become exhausted or less able to kill virus-infected or tumour cells." Dr Aj shows YET AGAIN that it DOES. 1/
Dr Aj shows how researchers have detected medical signs (markers) indicating T cell exhaustion from probable chronic stimulation in Long Covid. 2/
In Dr Aj's opinion, long haulers' T cells, that specifically responded to Covid, have become an exhausted or used-up resource due to chronic stimulation. 3/
Read 9 tweets
Dr-Leonardi Translate Bot Profile picture
Mar 25
Abstract: Covid behaves like a superantigen (SAg), sending immune systems into overdrive. What long-term risks are governments taking by letting a potential SAg spread? And what public health policies do we need to protect against the consequences of repeat exposure? 1/
SAgs are potent antigens that can stimulate a third of naive T cells, leading to abnormal immune response, inflammation, cytotoxicity, T-cell deletion + autoimmunity. They can also impair post-vaccination memory cell responses to unrelated antigens + memory cell activation. 2/
Lessons from Dengue: DENV + Covid share some features; T cell activation, neurological complications and autoimmunity. A conventional antigen, DENV activates HERV (viruses in our genome), which present proteins that act as SAgs and trigger autoimmunity. 3/
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(