The human body is home to a variety of microbiomes.
A new special issue of Science looks at our current understanding of these microbial communities, their effects on human health, and what remains to be discovered. fcld.ly/ny68b06 (THREAD) 🧵 #TheSystemicMicrobiome
Oral microbiota form distinct biofilms in different regions of the mouth that protect host tissues. When these biofilms become unbalanced, they may contribute to various diseases, including cancer and #Alzheimers.
A new #SciencePerspective discusses research that has identified brain systems that may be regulated by microbiota-derived molecules. fcld.ly/3kkigj8
The gut microbiota is associated with brain development and function, as well as altered emotional, motor, and cognitive behaviors in animals—but more research is needed in humans, a new #SciencePerspective highlights. fcld.ly/i0d0h3m
Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic threats.
A new #ScienceReview evaluates how the mutually beneficial relationships between communal microbes and human cells first arise during development and are maintained throughout life. fcld.ly/1ep4uye
Discovering how microorganisms regulate microbiota-host interactions is the next step in understanding the functional attributes of our microbial residents, argues a new #ScienceReview. fcld.ly/8wwstnv
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A new special issue of Science considers recent developments in monitoring, health effects, and policy dealing with #AirPollution. (THREAD 🧵) scim.ag/7Np
Two of the most popular mapping methods, mobile monitoring and low-cost sensor networks, have complementary strengths in measuring urban air quality, argues a new #ScienceReview. #AirPollution scim.ag/7PU
A #ScienceReview looks at the new air quality guidelines from @WHO and related challenges in improving air quality and health. #AirPollution scim.ag/7PV
Scientists have made several advances in the design of a class of #HIV vaccines that could offer broad protection against the virus, according to four new research papers published in Science, @ScienceTM, and @SciImmunology. (THREAD 🧵) scim.ag/6ZB
Leveraging cryo-electron microscopy, researchers in Science show a new approach that successfully primed and boosted quantities of B cells that secrete precursors to BG18—an anti-#HIV broadly neutralizing antibody—in a group of eight rhesus macaques. scim.ag/6YM
In a preclinical model, researchers in Science used sequential immunization to demonstrate the effective boosting of primed broadly neutralizing antibody precursors by two second-stage immunogens. scim.ag/6YN
Researchers have analyzed nonhuman #PrimateGenomes from more than 230 species. The results show how these data can help us learn about both nonhuman primate biology and our own health.
Learn more in a new special issue of Science: scim.ag/2Sq (THREAD 🧵)
A new study in Science presents whole-genome data from 233 primate species representing 86% of the primate genera and all 16 families. scim.ag/2Sr#PrimateGenomes
Despite the importance of nonhuman primates, reference genomes have been sequenced in <10% of species.
A new Science study presents high-quality reference genomes for 27 primate species, adding to available resources. scim.ag/2Ss#PrimateGenomes
In 2016, Science published the structure of the #NuclearPoreComplex—the sole gateway for macromolecules to enter or exit the nucleus.
A new special issue builds on that work, presenting the structure in unprecedented detail. fcld.ly/jfvwxfe (THREAD) 🧵
A composite structure of the cytoplasmic face of the human #NuclearPoreComplex provides a rich foundation for elucidating the molecular basis of #mRNA export and nucleoporin diseases, according to a new Science study. fcld.ly/3v012d9
In a new Science study, researchers present a near-atomic composite structure of the human #NuclearPoreComplex’s ~64-megadalton symmetric core. The findings provide a basis for future functional studies. fcld.ly/wgoa4cj
2021 has been a rich year in science, with a bounty of discoveries about biology and medicine, human prehistory, and the physical world.
Now, we want to know which one you consider this year’s top breakthrough. (THREAD) 🧵
Starting today, you can cast your vote in this thread for your favorite #BOTY in the three categories below. The winners will enter a final contest that runs 6–13 December. On 17 December, the People's Choice winner will be revealed. 🏆
If you would like to learn more about this year’s People’s Choice candidates, follow this thread after the polls for a short description of each, or read more here: fcld.ly/mwibvax
In preparation for #ShutDownSTEM tomorrow, 10 June, Science has made the following articles available without subscription or registration to help facilitate discussion.
"As more organizations and industries adopt digital tools to identify risk and allocate resources, the automation of racial discrimination is a growing concern."
In New York City, Latino and black people have been twice as likely to die from #COVID19 as white people. Research shows that this current pandemic is not atypical in hitting poor and marginalized communities harder. @NewsfromSciencefcld.ly/2ubp78q