The new strain of #Monkeypoxvirus has a large # of new mutations with a unique 'signature' that spells "human origin".

But it has recently burst onto the scene simultaneously in many countries. With a new, unique mode of transmission: male-to-male sex.

Something is amiss ...
The mutation profile can also be explained by propagating the virus in a lab, using cultures of human cells.

The source of the outbreak is: London.

And wouldn't you know it: there is a lab in London that has published making these very human-signature mutations in HIV-1.
So we only have to assume they used the same approach on the monkeypox virus and it either escaped or was deliberately released.

So this will be SARS2 and Wuhan Institute of Virology all over again.

Details are here:

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More from @tony_vandongen

Apr 23
A list of circumstantial pieces of evidence supporting a lab-linked origin for #COVID19:

1. 2018: WIV, EHA & UNC propose to DARPA to construct a SARS virus by insertion of a Furin Cleavage Site (FCS) in the spike protein, and humanize it by serial passaging. A blueprint for SC2.
2. Wuhan Institute of Virology (WIV) takes a database offline containing ~2,000 viral sequences on Sep 12, 2019.

3. Oct 2019: WIV staff members are hospitalized with pneumonia-like symptoms.

4. End of 2019: A WIV staff member disappears and hasn’t been seen since.
5. The CCP organizes a coronavirus exercise/drill at the Wuhan airport on Sep 26, 2019. 14 years after the SARS1 outbreak.
Either they were extremely prescient or they were informed about a laboratory ‘accident’.
Read 7 tweets
Apr 5
Do you want to solve the SARS2 origin?
I have some questions we need answers to:

1.Why was the public database with 20,000 viral sequences maintained by the Wuhan Institute of Virology (WIV) deleted on September 12, 2019?
The official explanation was that it had been hacked over 3,000 times. Really? In September of 2019? By whom? And why?
Interestingly, before it was taken down, the entire database was downloaded 200 times. These people knew it was going to disappear and made copies.
2.Why has this database not been made public after the pandemic outbreak? This makes it look like the database contains a secret that needs to be kept hidden. Does it contain the sequence of the “backbone” used to make SARS2? Inquiring minds want to know.
Read 10 tweets
Mar 29
SARS2 vs BANAL247 revisited. Image
Alignment of N-terminal domains of SARS2 and BANAL247, where transversions dominate.

11 C>T mutations out of a total of 132 = 8%.
No RNA editing. Image
Diagram showing transversions and transitions. Image
Read 4 tweets
Feb 26
Why #SARSCoV2 originated from #Omicron

Omicron broke onto the scene in November of 2021 in South Africa. It sported 63 new mutations.

And its ancestor was mysterious: a phylogenetic analysis put its predecessor close to the origin of the pandemic.

But how close?
The picture shows a small tree with only close relatives of SARS2. Not surprisingly, Omicron is the closest relative. But it ends up *above* SARS2, which would indicate it preceded it in time. The red dot is a common ancestor Omicron shares with SARS2. Let's call it Omega.
"Omega" (I know, the WHO is going to be mad) has a lot going for it as the origin of SARS2.

It is a LOT more closely related to SARS2 than the current favorites: RaTG13 and BANAL-20-52, which have 1154 and 940 mismatches with SARS2, whereas Omega (similar to Omicron) ~60.
Read 8 tweets
Feb 19
#SARSCoV2 originated from Omicron relative

Before pandemic it went undetected (mild cold)
Produced by serial passaging
Developed as a Live Attenuated Virus
68 mutations from unusual (lab) selection pressure
SARS2 reverted back to original Omicron in humans

Thx @KevinMcH3
This scenario solves a lot problems (it's parsimonious)

1. It explains the unusually large number of mutations in O: they are not mutations. O is wildtype.

2. The lab that created SARS2 didn't have to do any engineering, just serial passaging in cells and humanized mice.
3. It explains the mutations arising in the variants of concern (Alpha - Mu), almost all of which are seen Omicron (see below). They are simply reverting back to their original sequence now that the artificial laboratory selection pressure is removed.
Read 5 tweets
Jan 15
SARS2 and HIV-1 redux

In Feb of 2020, a preprint showing that the SARS2 spike protein has 4 regions of homology with HIV-1 (bit.ly/3rmBtYD) was forced to retract.

So where are these regions in the 3D protein structure?

😲All 4 regions are missing!

Surgically ...
Missing residues usually indicate flexible loops.

So where are these loops? What are they doing?

The first 3 are from the HIV-1 gp120 gene which allows it to bind to host cells containing the CD4 receptor: mostly immune cells like T-cells and macrophages.

O no, what if ...
Someone alerted Fauci to the same problem:
bit.ly/3qtU06e

What if the spike protein can interact with the CD4 receptor? Bad news.

Here are the regions in the structure. Spike forms a homo-trimer. The regions (red, yellow, and blue) come together at a peripheral point.
Read 6 tweets

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