1/5 This is BIG & I've really been looking forward to it. @DrNadolsky will be looking to see if he can reach a #LMHR phenotype while not being low carb or keto (or at a minimum, increase LDL-C to 200)
In short, can high consumption of saturated fat w/o being fat-adapted = #LMHR?
In short, can high consumption of saturated fat w/o being fat-adapted = #LMHR?
https://twitter.com/DrNadolsky/status/1537086514965921793
2/5 There's a bit of back-and-forth that originated this experiment which you can read about here π
And yes, this could literally result in my flying to him to confirm results directly with advanced bloodwork & RER (Respiratory Exchange Ratio)
And yes, this could literally result in my flying to him to confirm results directly with advanced bloodwork & RER (Respiratory Exchange Ratio)
https://twitter.com/realDaveFeldman/status/1533191720472432640?s=20&t=7fU-L_UmAeB6OhXZsRQ-lg
3/5 But more importantly, this gets to a very common assumption regarding #LMHRs -- that their phenotype can be mostly explained by higher consumption of saturated fat.
4/5 Ofc, it's worth repeating myself (and @nicknorwitz et al) agree saturated fat can impact LDL-C levels. But while we agree wrt additional component influences, we posit (and are exploring) the #LEM likelihood as the predominant influence for the #LMHR profile.
5/5 Which is why this is a powerful experiment. If one can demonstrate consistent #LMHR cut points while *not* being fat adapted (as confirmed by high RER, thus in contradiction with #LEM), that would be a very meaningful finding.
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